Patents by Inventor Robert A. Zambias

Robert A. Zambias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4966907
    Abstract: Novel position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: October 30, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Milton L. Hammond, Ihor E. Kopka, Stanley H. B. Wright, Robert A. Zambias
  • Patent number: 4963580
    Abstract: Position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzothiophenes and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: November 27, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Zambias, Milton L. Hammond
  • Patent number: 4884646
    Abstract: An anti-theft device for audio equipment which is accessible through an opening in a frame of an automotive vehicle, includes a rectangular sliding door movable in a vertical direction between a closed position in blocking relation to the opening and an open position permitting access to the audio equipment through the opening; a trackway which guides movement of the sliding door between the open and closed positions; a lead screw rotatably connected with the frame; a support nut connected with the sliding door for threadedly receiving the lead screw; a first gear fixedly mounted on the lead screw; a motor secured to the frame and having an output shaft with a second gear at the free end thereof, the second gear being in meshing engagement with the first gear; an actuation switch for selectively actuating the motor only when the ignition switch of the vehicle is on, to cause the sliding door to move along the trackway between the open and closed positions.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: December 5, 1989
    Inventor: Robert A. Zambias
  • Patent number: 4778818
    Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: October 18, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Norman P. Jensen, Milton L. Hammond, Robert A. Zambias, John McDonald, Kathleen M. Rupprecht
  • Patent number: 4746669
    Abstract: Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with diphosphoryl pentasulfide. The thiazole derivatives are found to be effective immunoregulants.
    Type: Grant
    Filed: March 26, 1987
    Date of Patent: May 24, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Ihor Kopka, Milton L. Hammond, Robert A. Zambias
  • Patent number: 4734421
    Abstract: Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: March 29, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Robert A. Zambias
  • Patent number: 4686235
    Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: August 11, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Norman P. Jensen, Milton L. Hammond, Robert A. Zambias, John McDonald, Kathleen M. Rupprecht
  • Patent number: 4596828
    Abstract: [(2-Hydroxy-5-alkoxyphenyl)methylthio]phenylmethanol and derivatives thereof were prepared from an appropriate 2-hydroxy-5-alkoxybenzaldehyde with a hydroxymethylthiophenol. These compounds were found to be potent anti-inflammatory agents.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: June 24, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Robert A. Zambias
  • Patent number: 4563476
    Abstract: Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine followed by reduction. These compounds were found to be potent topical anti-inflammatory agents.
    Type: Grant
    Filed: November 21, 1983
    Date of Patent: January 7, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Milton L. Hammond, Norman P. Jensen, Robert A. Zambias
  • Patent number: 4558067
    Abstract: Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzopyran and analogs thereof were prepared from an appropriate (6-hydroxy-2,3-dihydro-benzopyran-7-yl) formaldehyde or analog thereof with a substituted thiophenol. These compounds were found to be potent anti-inflammatory agents.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: December 10, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Kathryn L. Thompson, Robert A. Zambias, Milton L. Hammond, Michael N. Chang
  • Patent number: 4537903
    Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
    Type: Grant
    Filed: October 12, 1983
    Date of Patent: August 27, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Milton L. Hammond, Norman P. Jensen, John McDonald, Robert A. Zambias