Patents by Inventor Robert Aggeler

Robert Aggeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ENHANCED FLUORESCENCE
    Publication number: 20240042062
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 8, 2024
    Applicants: Life Technologies Corporation, Pierce Biotechnology, Inc.
    Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
  • Compositions and methods for enhanced fluorescence
    Patent number: 11865191
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: January 9, 2024
    Assignees: Life Technologies Corporation, Pierce Biotechnology, Inc.
    Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
  • Compositions and methods for enhanced fluorescence
    Patent number: 11857643
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: January 2, 2024
    Assignees: Life Technologies Corporation, Pierce Biotechnology, Inc.
    Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
  • Fluorescent Particles
    Publication number: 20220119701
    Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 21, 2022
    Inventors: Adam YORK, Eric WELCH, Kyle GEE, Xin WANG, Robert AGGELER, Yi-Zhen HU
  • Fluorescent particles
    Patent number: 11193057
    Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: December 7, 2021
    Assignee: Life Technologies Corporation
    Inventors: Adam York, Eric Welch, Kyle Gee, Xin Wang, Robert Aggeler, Yi-Zhen Hu
  • COMPOSITIONS AND METHODS FOR ENHANCED FLUORESCENCE
    Publication number: 20200330610
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Application
    Filed: May 22, 2020
    Publication date: October 22, 2020
    Inventors: Surbhi DESAI, Marie Christine NLEND, Kyle GEE, Matthew BAKER, Robert AGGELER, Scott SWEENEY, Aleksey RUKAVISHNIKOV, Shih-Jung HUANG
  • COMPOSITIONS AND METHODS FOR ENHANCED FLUORESCENCE
    Publication number: 20200261602
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Application
    Filed: March 11, 2020
    Publication date: August 20, 2020
    Inventors: Surbhi DESAI, Marie Christine NLEND, Kyle GEE, Matthew BAKER, Robert AGGELER, Scott SWEENEY, Aleksey RUKAVISHNIKOV, Shih-Jung HUANG
  • METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS
    Publication number: 20200179541
    Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 11, 2020
    Inventors: Brian AGNEW, Robert AGGELER, Hee Chol KANG, Aimei CHEN, Kyle GEE
  • Dibenzosilole monomers and polymers and methods for their preparation and use
    Patent number: 10570250
    Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: February 25, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle Gee, Xin Wang, Hee Chol Kang, Aimei Chen, Yexin Wu, Yi-Zhen Hu, Robert Aggeler, Quentin Low
  • Fluorescent Particles
    Publication number: 20190194532
    Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
    Type: Application
    Filed: August 24, 2017
    Publication date: June 27, 2019
    Inventors: Adam YORK, Eric WELCH, Kyle GEE, Xin WANG, Robert AGGELER, Yi-Zhen HU
  • Site-Specific Crosslinking of Antibodies
    Publication number: 20190177438
    Abstract: Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
    Type: Application
    Filed: June 16, 2017
    Publication date: June 13, 2019
    Inventors: Brian AGNEW, Robert AGGELER, Rolando BRAWER
  • DIBENZOSILOLE MONOMERS AND POLYMERS AND METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20180355098
    Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 13, 2018
    Inventors: Kyle Gee, Xin Wang, Hee Chol Kang, Aimei Chen, Yexin Wu, Yi-Zhen Hu, Robert Aggeler, Quentin Low
  • Dibenzosilole monomers and polymers and methods for their preparation and use
    Patent number: 10087280
    Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: October 2, 2018
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Xin Wang, Hee Chol Kang, Aimei Chen, Yexin Wu, Yi-Zhen Hu, Robert Aggeler, Quentin Low
  • COMPOSITIONS AND METHODS FOR ENHANCED FLUORESCENCE
    Publication number: 20180092993
    Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
    Type: Application
    Filed: September 1, 2017
    Publication date: April 5, 2018
    Inventors: Surbhi DESAI, Marie Christine NLEND, Kyle GEE, Matthew BAKER, Robert AGGELER, Scott SWEENEY, Aleksey RUKAVISHNIKOV, Shih-Jung HUANG
  • METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS
    Publication number: 20180078662
    Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
    Type: Application
    Filed: November 29, 2017
    Publication date: March 22, 2018
    Inventors: Brian AGNEW, Robert AGGELER, Hee Chol KANG, Aimei CHEN, Kyle GEE
  • DIBENZOSILOLE MONOMERS AND POLYMERS AND METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20170247504
    Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 31, 2017
    Inventors: Kyle GEE, Xin WANG, Hee Chol KANG, Aimei CHEN, Yexin WU, Yi-Zhen HU, Robert AGGELER, Quentin LOW
  • METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS
    Publication number: 20150246146
    Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
    Type: Application
    Filed: October 25, 2013
    Publication date: September 3, 2015
    Inventors: Brian Agnew, Robert Aggeler, Hee Chol Kang, Aimei Chen, Kyle Gee