Patents by Inventor Robert Alan Chrusciel

Robert Alan Chrusciel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 7358264
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: April 15, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 7354943
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: April 8, 2008
    Assignee: Pharmacia & Upjohn
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Aminediols for the treatment of Alzheimer's disease
    Patent number: 7053109
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: May 30, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Aza hydroxylated ethyl amine compounds
    Patent number: 6960664
    Abstract: Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2 and R20 are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: November 1, 2005
    Assignee: Pharmacia & UpJohn Company
    Inventors: Heinrich Schostarez, Robert Alan Chrusciel, Rebecca S. Centko
  • Aminediols for the treatment of Alzheimer's disease
    Patent number: 6906104
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 14, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6875790
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: April 5, 2005
    Assignees: G. D. Searle & Co., Pharmacia Corporation (Monsanto Corporation)
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 6864290
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: March 8, 2005
    Assignee: Pharmacia & Upjohn, LLP
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Aminediols for the treatment of Alzheimer's disease
    Publication number: 20040019086
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: January 29, 2004
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Cyclic sulfone containing retroviral protease inhibitors
    Publication number: 20040010143
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Application
    Filed: February 20, 2003
    Publication date: January 15, 2004
    Applicants: G.D. Searle & Co., Pharmacia Corporation (Monsanto Company)
    Inventors: Deborah E. Bertenshaw, Daniel P. Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Aza hydroxylated ethyl amine compounds utility
    Publication number: 20030229138
    Abstract: Disclosed are compounds of formula: 1
    Type: Application
    Filed: May 22, 2002
    Publication date: December 11, 2003
    Inventors: Heinrich Schostarez, Robert Alan Chrusciel, Rebecca S. Centko
  • Aminediols for the treatment of Alzheimer's disease
    Publication number: 20030092747
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: June 13, 2002
    Publication date: May 15, 2003
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Statine derivatives for the treatment of Alzheimer's disease
    Publication number: 20030083356
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: May 1, 2003
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6552203
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: April 22, 2003
    Assignee: Monsanto Company
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Cyclic sulfone containing retroviral protease inhibitors
    Publication number: 20020107264
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Application
    Filed: October 11, 2001
    Publication date: August 8, 2002
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6329524
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: December 11, 2001
    Assignee: Monsanto Company
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6265583
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: July 24, 2001
    Assignees: G. D. Searle & Co., Monsanto Company
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 5849784
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: December 15, 1998
    Assignees: GD Searle & Co., Monsanto Co.
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
    Patent number: 5677296
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 14, 1997
    Assignee: G.D. Searle & Co.
    Inventors: Robert Alan Chrusciel, Timothy Joseph Hagen, E. Ann Hallinan, Jinglin Li, Sofya Tsymbalov, David B. Reitz