Patents by Inventor Robert Alan Figler

Robert Alan Figler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIRNAS TARGETING SLC10A1 TRANSCRIPTS, COMPOSITIONS AND USES THEREOF
    Publication number: 20240254485
    Abstract: The present invention relates to siRNA molecules targeting a SLC10A1 mRNA transcript and methods of using the siRNA compositions for treatment of a NTCP associated disorder.
    Type: Application
    Filed: January 12, 2024
    Publication date: August 1, 2024
    Inventors: Ryan Feaver, Brian Johns, Jennifer Marks, Emile Velthuisen, Maria Sol Collado, Robert Alan Figler
  • Method to treat sickle cell disease
    Patent number: 8178509
    Abstract: The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rolipram).
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: May 15, 2012
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Kori Wallace, Robert Alan Figler, Jayson M. Rieger
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 8158604
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 17, 2012
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having A2A agonist activity
    Patent number: 7989431
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 2, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20110136755
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 9, 2011
    Applicant: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7875595
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: January 25, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF
    Publication number: 20100152127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Application
    Filed: February 24, 2010
    Publication date: June 17, 2010
    Applicant: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 7737127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 15, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090298788
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 3, 2009
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having Aagonist activity
    Patent number: 7605143
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 20, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090253647
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 8, 2009
    Inventors: Jayson M. Rieger, Jeol M. Linden, Timothy L. MacDonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7576069
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: August 18, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7442687
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 28, 2008
    Assignee: The University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-propynyl adenosine analogs having Aagonist activity and compositions thereof
    Patent number: 7214665
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 8, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Publication number: 20030186926
    Abstract: The invention provides compounds having the following general formula (I): 1
    Type: Application
    Filed: October 1, 2002
    Publication date: October 2, 2003
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. MacDonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler