Patents by Inventor Robert Alan Figlin

Robert Alan Figlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
    Patent number: 6838081
    Abstract: The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CD14+ cells and precursors in bone marrow. Thus, administration of GM-CSF and IL-4 can be used as a form of cytokine immunotherapy. One embodiment of the present invention involves systemic administration of GM-CSF and IL-4. In this embodiment, APC are required to directly access tumor antigens as they exist in vivo within the patient. A further embodiment of the present invention involves co-administration of a tumor-associated or tumor-specific antigen, with GM-CSF and IL-4, to induce antigen-specific immunity mediated by APC. Yet another embodiment of the present invention describes systemic administration of GM-CSF and IL-4 to achieve reduced tumor burden.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: January 4, 2005
    Assignee: The Regents of the University of California
    Inventors: Michael Derek Roth, Robert Alan Figlin, Sylvia Marie Kiertscher, Barbara Jennifer Gitlitz