Patents by Inventor Robert Alexander Pulz

Robert Alexander Pulz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARBOXAMIDE DERIVATIVES
    Publication number: 20230301970
    Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 28, 2023
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef TROXLER-SCHWAB, Joe WRIGGLESWORTH
  • Carboxamide derivatives
    Patent number: 11672782
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: June 13, 2023
    Assignee: NOVARTIS AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20210052554
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: November 4, 2020
    Publication date: February 25, 2021
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20200268718
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 14, 2020
    Publication date: August 27, 2020
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef TROXLER, Joe WRIGGLESWORTH
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20190381011
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 19, 2019
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • Carboxamide derivatives
    Patent number: 10195181
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: February 5, 2019
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
  • Carboxamide derivatives
    Patent number: 9931319
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: April 3, 2018
    Assignee: Novartis AG
    Inventors: Anne-Marie Edwards, Mahbub Ahmed, Robert Alexander Pulz, Lisa Ann Rooney, Nichola Smith, Thomas Josef Troxler
  • CARBOXAMIDE INHIBITORS
    Publication number: 20170088546
    Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 30, 2017
    Applicant: NOVARTIS AG
    Inventors: Luca ARISTA, Rene BEERLI, Simona COTESTA, Pier Luca D'ALESSANDRO, Rene LATTMANN, Robert Alexander PULZ, Thomas J. TROXLER
  • CARBOXAMIDE INHIBITORS
    Publication number: 20170088545
    Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 30, 2017
    Applicant: Novartis AG
    Inventors: Luca ARISTA, Simona COTESTA, Pier D'ALESSANDRO, Anne-Marie EDWARDS, Rene LATTMANN, Dimitrios LIZOS, Robert Alexander PULZ, Lisa Ann ROONEY, Nichola SMITH, Jessica Louise TAYLOR, Thomas J. TROXLER
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20170014388
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: June 16, 2016
    Publication date: January 19, 2017
    Applicant: NOVARTIS AG
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20170000770
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: June 29, 2016
    Publication date: January 5, 2017
    Applicant: NOVARTIS AG
    Inventors: Anne-Marie EDWARDS, Mahbub AHMED, Robert Alexander PULZ, Lisa Ann ROONEY, Nichola SMITH, Thomas Josef TROXLER
  • Carboxamide derivatives
    Patent number: 9403833
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: August 2, 2016
    Assignee: Novartis AG
    Inventors: Anne-Marie Edwards, Mahbub Ahmed, Robert Alexander Pulz, Lisa Ann Rooney, Nichola Smith, Thomas Josef Troxler
  • Carboxamide derivatives
    Patent number: 9403810
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: August 2, 2016
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
  • Pyrrolo pyrimidine derivatives
    Patent number: 9233111
    Abstract: The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.
    Type: Grant
    Filed: July 7, 2012
    Date of Patent: January 12, 2016
    Assignee: NOVARTIS AG
    Inventors: Richard Heng, Elizabeth Kate Hoegenauer, Guido Koch, Robert Alexander Pulz, Anna Vulpetti, Rudolf Waelchli
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20150329549
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 19, 2015
    Applicant: NOVARTIS AG
    Inventors: Anne-Marie EDWARDS, Mahbub AHMED, Robert Alexander PULZ, Lisa Ann ROONEY, Nichola SMITH, Thomas Josef TROXLER
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20150329529
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 19, 2015
    Applicant: NOVARTIS AG
    Inventors: Kamlesh Jagdis BALA, Andrew BEARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nicole SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • NOVEL PYRROLO PYRIMIDINE DERIVATIVES
    Publication number: 20140243306
    Abstract: The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.
    Type: Application
    Filed: July 7, 2012
    Publication date: August 28, 2014
    Applicant: NOVARTIS AG
    Inventors: Richard Heng, Elizabeth Kate Hoegenauer, Guido Koch, Robert Alexander Pulz, Anna Vulpetti, Rudolf Waelchli
  • Organic compounds
    Patent number: 8431578
    Abstract: Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: April 30, 2013
    Assignee: Novartis AG
    Inventors: Peter Hunt, Catherine Leblanc, Robert Alexander Pulz, Nikolaus Johannes Stiefl
  • Organic compounds
    Patent number: 8343966
    Abstract: Compounds of formula I in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: January 1, 2013
    Assignee: Novartis AG
    Inventors: Claire Adcock, Urs Baettig, Peter Hunt, Catherine Leblanc, Maude Nadine Pierrette Pipet, Robert Alexander Pulz, Katrin Spiegel, Nikolaus Johannes Stiefl
  • Pyrrolopyrimidines and pyrrolopyridines
    Patent number: 8314112
    Abstract: Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: November 20, 2012
    Assignee: Novartis AG
    Inventors: Catherine Leblanc, Robert Alexander Pulz, Nikolaus Johannes Stiefl