Patents by Inventor Robert Alexander Walker Johnstone

Robert Alexander Walker Johnstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7825069
    Abstract: Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalization moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalization moiety. Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalization moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: November 2, 2010
    Assignee: Electrophoretics Limited
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Patent number: 7816304
    Abstract: Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalization moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: October 19, 2010
    Assignee: Electrophoretics Limited
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Publication number: 20080167197
    Abstract: Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalisation moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
    Type: Application
    Filed: August 20, 2007
    Publication date: July 10, 2008
    Applicant: ELECTROPHORETICS LIMITED
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Publication number: 20080145850
    Abstract: Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalisation moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
    Type: Application
    Filed: August 20, 2007
    Publication date: June 19, 2008
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Patent number: 7294456
    Abstract: Provided herein are sets of mass labels. Each mass label in a set includes 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterised as having a mass different from that of all other mass marker moieties in the set as determined by mass spectrometry. Further, each mass normalisation moiety ensures that each mass label in the set has substantially the same mass as determined by mass spectrometry.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: November 13, 2007
    Assignee: Electrophoretics Limited
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Patent number: 6702995
    Abstract: The present invention relates to a delivery system useful for water-insoluble drugs, therapeutic agents, and diagnostic agents. More particularly, it relates to a method of packaging water-insoluble substances such as, for example, a drug or other therapeutic or diagnostic agent, to facilitate uptake into the human or animal body and to substances packaged by this method. The packaging method renders the water-insoluble substance water-soluble by packaging it in an amphiphilic polymer that is soluble in water. The invention also relates to a method of treating cancer through administering a water-insoluble drug or other therapeutic or diagnostic agent packaged according to the method describe above.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: March 9, 2004
    Assignee: TheRyte, Ltd.
    Inventors: Robert Alexander Walker Johnstone, Hilmar Meek Warenius, Thelmo Luis Coutinho Figueiredo, Alexandra Maria Sørensen
  • Patent number: 6699668
    Abstract: An array of hybridisation probes, each of which comprises a mass label linked to a known base sequence of predetermined length, wherein each mass label of the array, optionally together with the known base sequence, is relatable to that base sequence by mass spectrometry.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: March 2, 2004
    Assignee: XZillion GmbH & Co.
    Inventors: Günter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Publication number: 20030194717
    Abstract: Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalisation moiety, the mass marker moiety being fragmentation resistant, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry.
    Type: Application
    Filed: February 13, 2003
    Publication date: October 16, 2003
    Inventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Publication number: 20030161883
    Abstract: Provided is a composition comprising: (a) an active component having a therapeutic and/or diagnostic activity; and (b) a delivery component for facilitating delivery of the active component, wherein the delivery component has a therapeutic and/or diagnostic activity.
    Type: Application
    Filed: February 24, 2003
    Publication date: August 28, 2003
    Inventors: Hilmar Meek Warenius, Robert Alexander Walker Johnstone
  • Patent number: 6384264
    Abstract: Organic photoprecursors of amines are provided for use in photosensitive imaging systems, finding particular application in the preparation of lithographic printing plates. Said photoprecursors generate free amines on exposure to long wavelength UV or visible radiation, have high solubility in organic solvents, and include photolabile 2-nitrobenzyl functional groups. Methods for the synthesis of the photoprecursors are described, and the use of the said photoprecursors for the production of printing plates using both positive working and negative working techniques are discussed.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: May 7, 2002
    Assignee: Agfa-Gevaert
    Inventors: Maria de Lurdes dos Santos Cristiano, John Kynaston Davies, Sharon Dowd, Robert Alexander Walker Johnstone, Michael John Pratt, John Robert Wade
  • Patent number: 6287780
    Abstract: The present invention provides a compound having the following formula: N-L-M wherein N comprises one or more nucleic acid bases, L is either a direct bond between N and M or L comprises a linker moiety, and M comprises a mass marker comprising an aryl ether.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: September 11, 2001
    Assignee: BRAX Group Limited
    Inventors: Günter Schmidt, Andrew Hugin Thompson, Robert Alexander Walker Johnstone
  • Patent number: 6171756
    Abstract: Organic photoprecursors of amines are provided for use in photosensitive imaging systems, finding particular application in the preparation of lithographic printing plates. Said photoprecursors generate free amines on exposure to long wavelength UV or visible radiation, have high solubility in organic solvents, and include photolabile 2-nitrobenzyl functional groups. Methods for the synthesis of the photoprecursors are described, and the use of the said photoprecursors for the production of printing plates using both positive working and negative working techniques are discussed.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: January 9, 2001
    Assignee: Afga-Gevaert, N.V.
    Inventors: Maria de Lurdes dos Santos Cristiano, John Kynaston Davies, Sharon Dowd, Robert Alexander Walker Johnstone, Michael John Pratt, John Robert Wade
  • Patent number: 5675042
    Abstract: Phenols, and related aromatic compounds, phenolic ethers, can be hydroxylated selectively using hydrogen peroxide in the presence of an amorphous or crystalline tin or cerium phosphate catalyst in a solvent containing an aliphatic carboxylic acid. The process is particularly suitable for phenol itself, and advantageously employs a catalyst obtained by heating an hydrated amorphous or crystalline tin or cerium phosphate for example at about 100.degree. C. A convenient hydroxylation temperature is in the range of 50.degree. to 90.degree. C., and a convenient solvent is acetic acid.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: October 7, 1997
    Assignee: Solvay Interox Limited
    Inventor: Robert Alexander Walker Johnstone