Abstract: A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Abstract: A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Abstract: We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. We found that tissue expression of proteins PSMC5, TFRC and PPP1R12A increases during tumor development from normal to pre-malignant to pancreatic tumor. In addition, these proteins were shown to be pancreatic cancer-associated antigens that are recognized by post-vaccination antibodies in the sera of patients that received the vaccine and have demonstrated a favorable disease free survival.

Abstract: We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. We found that tissue expression of proteins PSMC5, TFRC and PPP1R12A increases during tumor development from normal to pre-malignant to pancreatic tumor. In addition, these proteins were shown to be pancreatic cancer-associated antigens that are recognized by post-vaccination antibodies in the sera of patients that received the vaccine and have demonstrated a favorable disease free survival.

Abstract: A method of DRM protection for an image or a series of images or a succession of video frames, comprises: generating a reversible transform; applying the reversible transform to a source image; compressing the transformed image into a bitstream; and supplying the bitstream to a recipient for consumption. At the recipient the bitstream is decompressed and sent to the image display hardware with the transform still in place. A key is used to generate the inverse transform at the recipient and the inverse transform is then carried out in the image display hardware. An additional transform may be applied to the image following the inverse transform to offset pixels from an average value. Thus the source image itself is never exposed at the recipient although the image can be correctly viewed.

Abstract: We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. We found that tissue expression of proteins PSMC5, TFRC and PPP1R12A increases during tumor development from normal to pre-malignant to pancreatic tumor. In addition, these proteins were shown to be pancreatic cancer-associated antigens that are recognized by post-vaccination antibodies in the sera of patients that received the vaccine and have demonstrated a favorable disease free survival.

Abstract: A method of verifying, controlling and limiting distribution of digital artwork files, comprises designating a trusted third party registration server; receiving a digital artwork; registering the received artwork at the registration server; defining an allowed number of copies of the registered artwork, the allowed number being at least one; creating individual copies of the artwork up to the allowed number; at the registration server assigning an individual copy to a user; supplying the user with a file comprising an electronically watermarked version of the individual copy; allowing the user to relinquish the individual copy; upon relinquishing, making the individual copy available to a second user by repeating the supplying stage.

Abstract: A method of DRM protection for an image or a series of images or a succession of video frames, comprises: generating a reversible transform; applying the reversible transform to a source image; compressing the transformed image into a bitstream; and supplying the bitstream to a recipient for consumption. At the recipient the bitstream is decompressed and sent to the image display hardware with the transform still in place. A key is used to generate the inverse transform at the recipient and the inverse transform is then carried out in the image display hardware. An additional transform may be applied to the image following the inverse transform to offset pixels from an average value. Thus the source image itself is never exposed at the recipient although the image can be correctly viewed.

Abstract: We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. We found that tissue expression of proteins PSMC5, TFRC and PPP1R12A increases during tumor development from normal to pre-malignant to pancreatic tumor. In addition, these proteins were shown to be pancreatic cancer-associated antigens that are recognized by post-vaccination antibodies in the sera of patients that received the vaccine and have demonstrated a favorable disease free survival.

Abstract: A method, computer program product, and system is described. A patient condition associated with a patient record is identified based upon, at least in part, a first input associated with the patient record. A point-of-care prompt is provided based upon, at least in part, the patient condition and clinical authority information. A point-of-care input, associated with at least in part, one or more of education material, a condition assessment, co-morbidity information, a diagnosis protocol, a treatment protocol, medication information, clinical order information, visit order information, patient resource information, and care planning information, is received.

Abstract: An apparatus includes a containment member having a containment member interior cavity to contain foam precursor compartments, and a release member to release foam precursor components contained within the foam precursor compartments in response to a specific relative movement produced between the release member and the containment member. The apparatus may form a portion of a foam cushion forming apparatus.

Abstract: A foam-in-place apparatus includes a foam containment unit, a foam precursor storage unit, and a foam precursor heating unit, in one embodiment. During operation, the foam precursor heating unit is activated to provide activation heat to one or more foam precursor components stored within the foam precursor storage unit. The activation heat may cause temperatures of one or more of the foam precursor components to increase to temperatures within an activation temperature range. The pre-heated component or components are combined to produce an expansive foam, which is deployed in the foam containment unit, and which causes the foam containment unit to expand and displace or contour around any physical objects within the expansion limits of the foam containment unit.

Abstract: In an embodiment, a catheter apparatus includes a catheter tube having a hollow catheter interior, a proximal catheter end, and a distal catheter end. A catheter connector is coupled to the catheter tube at the proximal catheter end. The apparatus further includes a needle having a hollow interior channel, a proximal needle end, and an insertion point. A needle hub is coupled to the needle at the proximal needle end. In an embodiment, the apparatus further includes a retraction mechanism to enable the insertion point to be retracted to a position inside the catheter apparatus.

Abstract: In an embodiment, a catheter apparatus includes a catheter and a substantially soluble insertion point extending beyond a distal end of the catheter. The substantially soluble insertion point may be connected to a substantially soluble needle shaft or to a non-soluble needle shaft. The catheter apparatus includes a partial retraction mechanism, in an embodiment, which enables the substantially soluble insertion point to be retracted to a position within the catheter. In other embodiments, the substantially soluble insertion point is fully retractable (i.e., removable) or is non-retractable.

Abstract: A foam-in-place apparatus includes a foam containment unit, a foam precursor storage unit, and a foam precursor heating unit, in one embodiment. During operation, the foam precursor heating unit is activated to provide activation heat to one or more foam precursor components stored within the foam precursor storage unit. The activation heat may cause temperatures of one or more of the foam precursor components to increase to temperatures within an activation temperature range. The pre-heated component or components are combined to produce an expansive foam, which is deployed in the foam containment unit, and which causes the foam containment unit to expand and displace or contour around any physical objects within the expansion limits of the foam containment unit.

Abstract: An apparatus functions to immobilize a body part or other physical object. In an embodiment, the apparatus includes a base, one or more flexible bags, and one or more foam precursor packages. In an embodiment, a foam precursor package includes a first chamber, in which a first foam precursor is deployed, and a second chamber, in which a second foam precursor is deployed. The foam precursor package also includes a separation mechanism, which when physically agitated, functions to enable the first and second foam precursors to combine. The combination produces a reaction, which results in the formation of a foam. The foam substantially fills the one or more flexible bags. In an embodiment, a portion of a patient's body is placed in proximity to the apparatus, prior to combination of the precursors. When the foam precursor package is activated, the foam and flexible bags contour around and at least partially immobilize the body part.

Abstract: A game system, incorporating co-existent interaction between a virtual character 20 and a user 10 in the real world, comprising a virtual character 20 in a computer sub-system 12,14 including a computer device 12 and means 38,40,42 for inputting real-world actions of a user in the real world into said sub-system 12,14, whereby actions of a user in the real world, at a pre-chosen real world location 36, other than correlative movements, are recorded and inputted into the computer sub-system and influence the character 20 in the virtual world 16.