Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: In one embodiment, an apparatus for docking vehicles includes a housing structure comprising two side portions and a top portion connecting the two side portions, the two side portions and the top portion forming a cavity for receiving a portion of a vehicle, an electrically-powered locking assembly, carried by the housing structure, for securing the housing structure to the vehicle in response to the portion of the vehicle being received by the cavity of the housing structure, an electrically-powered communication device, coupled to the housing structure, for enabling data communication over a network, and a solar panel, carried by an external surface of one of the side portions of the housing structure, for independently converting light received by the solar panel into electrical energy.

Abstract: A fence system, post, and method of manufacture are herein disclosed. The post includes a shaft, and an overmold layer extending at least a portion of a length of the shaft. The overmold layer includes a plurality of external attachment locating features for selectively securing wire locating attachments at predetermined locations along the length of the shaft. The fence system includes a plurality of the posts and a plurality of wire locating attachments configured to be attached to the external attachment locating features of the posts.

Abstract: Apparatus includes a sample holder with a cavity and a plurality of devices configured to hold a curvature of a curved substrate in a fixed configuration. Apparatus includes two prisms with a viewing apparatus of the sample holder configured to translate therebetween. Methods can include disposing the curved substrate in the sample holder, transmitting a first beam, translating the sample holder, and transmitting a second beam. Alternatively, apparatus include a light scattering-polarimetry sub-system configured to emit a first beam to impinge an end surface of coupling prism and detect at least a portion of the first beam impinging the first surface of the coupling prism. The apparatus includes an evanescent prism coupling spectroscopy sub-system configured to emit a second beam to impinge a first surface of the coupling system and detect at least a portion of the second beam impinging the second surface of the coupling prism.

Abstract: The invention features a headset, and systems including the headset, equipped with electrical sensors. The headset is suitable for use by a child and suitable for use in a gaming system, e.g., to train attention.

Abstract: A vehicle includes a chassis, a body, and a door assembly. The body is supported by the chassis, and defines a driver compartment and a cargo compartment. The driver compartment has a cab opening and the cargo compartment has a cargo opening. The door assembly is coupled to the body and provides selective access into the driver compartment and into the cargo compartment through the cab opening and cargo opening, respectively. The door assembly includes a first door and a second door. The first door is movable between a first position extending across the cab opening and a second position extending at least partially across a portion of the cab opening. The second door is movable between a third position extending across the cargo opening and a fourth position extending at least partially across a portion of the cab opening.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A comb attachment for mounting to a hair-care appliance configured to supply a heated airflow. The comb attachment includes a housing defining an inlet for receiving an airflow from the appliance when mounted thereto and an outlet fluidly connected to the inlet for discharging the airflow. The attachment further includes first and second longitudinally extending rows of outer protrusions mounted to the housing so as to extend across or alongside the outlet. The attachment also includes a longitudinally extending row of inner protrusions mounted to the housing so as to be interposed between the first and second rows of outer protrusions.

Abstract: A catheter can restore the patency of a body lumen, for example, by removing tissue from a body lumen (e.g., a blood vessel). The catheter can be a rotational catheter having a rotatable drive shaft and a tissue-removing element secured to the drive shaft to be driven in rotation by the drive shaft. The catheter can have an abrasive burr configured to abrade tissue in a body lumen. The catheter can have an expandable tissue-removing element. The catheter can include a balloon and an inflation conduit. The catheter can also be configured to move over a guidewire through a body lumen. In one embodiment, the catheter comprises an over-the-wire, balloon-expandable, rotational, and abrasive tissue-removing catheter.

Abstract: A method includes obtaining training data including a plurality of training audio signals and corresponding transcripts. Each training audio signal is spoken by a target speaker in a first accent/dialect. For each training audio signal of the training data, the method includes generating a training synthesized speech representation spoken by the target speaker in a second accent/dialect different than the first accent/dialect and training a text-to-speech (TTS) system based on the corresponding transcript and the training synthesized speech representation. The method also includes receiving an input text utterance to be synthesized into speech in the second accent/dialect. The method also includes obtaining conditioning inputs that include a speaker embedding and an accent/dialect identifier that identifies the second accent/dialect.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating speech from text. One of the systems includes one or more computers and one or more storage devices storing instructions that when executed by one or more computers cause the one or more computers to implement: a sequence-to-sequence recurrent neural network configured to: receive a sequence of characters in a particular natural language, and process the sequence of characters to generate a spectrogram of a verbal utterance of the sequence of characters in the particular natural language; and a subsystem configured to: receive the sequence of characters in the particular natural language, and provide the sequence of characters as input to the sequence-to-sequence recurrent neural network to obtain as output the spectrogram of the verbal utterance of the sequence of characters in the particular natural language.

Abstract: A light-emitting module structure comprises a support substrate and a micro-module disposed on or in the support substrate that extends over only a portion of the support substrate. The micro-module comprises a rigid module substrate, an inorganic light-emitting diode, a power source, and a control circuit. The inorganic light-emitting diode, the power source, and the control circuit are disposed on or in the module substrate and the control circuit receives power from the power source to control the inorganic light-emitting diode to emit light. A light conductor is disposed on or in the support substrate and in alignment with the micro-module so that the inorganic light-emitting diode is disposed to emit light into the light conductor and the light conductor conducts the light beyond the micro-module to emit the light from the light conductor.

Abstract: Embodiments are directed to generating service offerings based on associated content and historical data. Content from a content panel may be provided. Subjects associated with the content may be determined based on information included in the content. A service category associated with the subjects may be determined based on services provided by a healthcare organization. An offering model may be employed to generate an offering panel based on the service category. The offering model may be evaluated based on monitoring interactions between users and the offering panel. Results of the evaluation may be employed to perform further actions including: designating the offering model for retraining based on the performance metrics; retraining the designated offering model; employing the retrained offering model to generate other offering panels for display to the users; or the like.

Abstract: A patient interface, such as a nasal cannula, including a body to be positioned upon a user (preferably such as a user's face), the body including at least one (and preferably a pair of) nasal prong(s), the or each nasal prong including a lumen capable of being fluidly connected thereto for fluid communication with a supply of breathable gas, the or each nasal prong to be in a configuration either inserted into, or to direct a flow of gas toward, a nare or the nares of the user's nose, wherein the body includes at least one element responsive to force(s) or movement(s), or both, experienced by at least a first region of the patient interface.

Abstract: The present disclosure provides semirigid pouch designs and methods of manufacturing pouches. Such pouches can be made of plastic or non-plastic materials and may be easily sorted and recycled within existing rigid packaging recycling streams. The pouches are semirigid, while flexible, and will substantially retain their shape during and following product dispensing. This is accomplished by sealing a lower edge of a wall of semirigid plastic or non-plastic materials to a rigid or semirigid base, enabling the pouch to stand up on the base. Portions of an upper edge of the wall are affixed together to form a space to hold the foodstuffs. Further, the present pouch design does not require an additional label to be applied by the manufacturer, as the present design provides a large, uninterrupted, surface area for printing of advertisements and/or labels directly to the outer surface of the pouch.

Abstract: Described herein is an absorbent article including (a) an absorbent core, a first nonwoven material, a second nonwoven material, and a bond area; and (b) a polymeric filler composition disposed within the bond area. The polymeric filler composition has less than 5% of a tackifier. The polymeric filler composition is chosen from a propylene butene copolymer, a polypropylene homopolymer, a propylene ethylene copolymer, and mixtures thereof. The polymeric filler composition has a Tensile Strength at Yield of from about 0.5 MPa to about 10 MPa.

Abstract: A fan assembly includes a fan body, a motor-driven impeller contained within the fan body and arranged to generate an air flow, a nozzle including a nozzle body having an air inlet arranged to receive the air flow from the fan body, and one or more air outlets arranged to emit the airflow from the fan assembly. The fan assembly further includes a nozzle retaining mechanism for releasably retaining the nozzle on the fan body, and a rotation mechanism for rotating the nozzle body relative to the fan body. The nozzle rotation mechanism includes a rotation motor arranged to drive a drive member and a driven member that is arranged to be driven by the drive member to rotate around a rotation axis.