Abstract: Apparatus and method for multi-spectral retinal imaging with wide field of view including multi-spectral fundus auto fluorescence. The present disclosure describes an apparatus having a light source assembly for multi-spectral retinal illumination for wide field of view retinal imaging including fluorescence retinal imaging. The present apparatus and methods can obtain retinal images at a wide range of spectral wavelengths to provide an effective, efficient, and extended retinal disease identification, monitoring and diagnostics.

Abstract: The invention also relates to antigen binding proteins and related fragments thereof for binding Von Willebrand factor (VWF) and uses thereof. In one aspect, the present invention provides an antigen binding protein comprising an antigen binding domain that binds to or specifically binds to Von Willebrand factor (VWF) under shear gradient conditions. Preferably, the antigen binding protein comprises an antigen binding domain that does not bind to VWF under constant shear conditions.

Abstract: Apparatus for straightening and flattening a side wall of a body lumen or body cavity so as to provide three dimensional exposure of a lesion or abnormality within the body lumen or body cavity, and simultaneously providing for the stabilization or docking of the working end of an endoscope or surgical tool, the apparatus comprising: a deployable hoop expander comprising a structure defining a volume; the deployable hoop expander being configured so as to be transitionable between (i) a reduced cross-sectional configuration, and (ii) an expanded cross-sectional configuration, whereby the deployable hoop expander can be configured in its reduced cross-sectional configuration for easy insertion into a body lumen, and it can thereafter be re-configured into its expanded cross-sectional configuration so as to engage, straighten and flatten the side wall of the body lumen, whereby to provide three dimensional exposure of the lesion or abnormality within the body lumen or body cavity, the deployable hoop expande

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.

Abstract: Apparatus for straightening and flattening a side wall of a body lumen or body cavity so as to provide three dimensional exposure of an abnormality within the body lumen, and simultaneously providing for the stabilization of the working end of an endoscope or surgical tool, the apparatus comprising a deployable hoop expander comprising a structure defining a volume and being configured so as to be transitionable between a reduced cross-sectional configuration for easy insertion into a body lumen and an expanded cross-sectional configuration for engaging, straightening and flattening the side wall of the body lumen, whereby to provide three dimensional exposure of the abnormality within the body lumen, the deployable hoop expander being configured for simultaneously providing for the docking of the end of the endoscope or other instrument so as to stabilize the same for endoscopic viewing and/or therapy.

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: Apparatus and method for accessing the wall of a body lumen while simultaneously providing zone isolation and fluid bypass capability, the apparatus comprising: an erectable proximal isolation barrier capable of making a sealing engagement with the wall of the body lumen; an erectable distal isolation barrier capable of making a sealing engagement with the wall of the body lumen; a bypass channel secured to, and extending between, the proximal isolation barrier and the distal isolation barrier, the bypass channel comprising a lumen communicating with the region proximal to the proximal isolation barrier and with the region distal to the distal isolation barrier; and a working catheter passing through the proximal isolation barrier and terminating short of the distal isolation barrier, the working catheter providing a central lumen for providing access to the wall of the body lumen between the proximal isolation barrier and the distal isolation barrier.

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.

Abstract: An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame configured to assume a collapsed configuration and an expanded configuration; and a closed face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the closed face is configured so as to obstruct flow therethrough.

Abstract: An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.

Abstract: Method and system for providing dynamic configuration of link redundancy in data network based on detection of dynamic changes in the network topology including the steps of detecting data network topology, determining a number of data paths from a node in the data network topology to each of a respective pair of peer nodes coupled to the node by a corresponding interface, determining a data path in the data network topology between the peer nodes, calculating a set of nodes reachable via each interface coupled to the node and the respective peer node in the data network topology, and comparing the set of calculated nodes is provided.

Abstract: Method and system for providing dynamic network data traffic monitoring including monitoring a data network, detecting a change in the data network, initiating a span session based on the detected change in the data network, and dynamically modifying network configuration based on the detected change in the data network is disclosed.

Abstract: A method and apparatus for processing a substrate utilizing a rotating substrate support are disclosed herein. In one embodiment, an apparatus for processing a substrate includes a chamber having a substrate support assembly disposed within the chamber. The substrate support assembly includes a substrate support having a support surface and a heater disposed beneath the support surface. A shaft is coupled to the substrate support and a motor is coupled to the shaft through a rotor to provide rotary movement to the substrate support. A seal block is disposed around the rotor and forms a seal therewith. The seal block has at least one seal and at least one channel disposed along the interface between the seal block and the shaft. A port is coupled to each channel for connecting to a pump. A lift mechanism is coupled to the shaft for raising and lowering the substrate support.

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: A method and system provides dynamic configuration of network elements using hierarchical inheritance. The method includes monitoring a data network, detecting a change associated with a configuration of the data network, identifying one or more member groups affected by the detected change, and modifying the network configuration for the one or more member groups in the data network.

Abstract: Method and system for providing dynamic network data traffic monitoring including monitoring a data network, detecting a change in the data network, initiating a span session based on the detected change in the data network, and dynamically modifying network configuration based on the detected change in the data network is disclosed.

Abstract: An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.