Patents by Inventor Robert Anthony BLAKE

Robert Anthony BLAKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugated chemical inducers of degradation and methods of use
    Patent number: 12440706
    Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: October 14, 2025
    Assignee: Genentech, Inc.
    Inventors: Peter Dragovich, Thomas Pillow, Robert Anthony Blake, Ingrid Wertz
  • TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER
    Publication number: 20250084096
    Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
    Type: Application
    Filed: October 11, 2024
    Publication date: March 13, 2025
    Applicant: Genentech, Inc.
    Inventors: Robert Anthony BLAKE, Peter DRAGOVICH, Lewis J. GAZZARD, Susan KAUFMAN, Tracy KLEINHEINZ, Thomas PILLOW, Steven T. STABEN, Binqing WEI
  • Tert-butyl (s)-2-(4-(phenyl)-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer
    Patent number: 12152040
    Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: November 26, 2024
    Assignee: Genentech, Inc.
    Inventors: Robert Anthony Blake, Peter Dragovich, Lewis J. Gazzard, Susan Kaufman, Tracy Kleinheinz, Thomas Pillow, Steven T. Staben, Binqing Wei
  • CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE
    Publication number: 20230067037
    Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.
    Type: Application
    Filed: April 23, 2021
    Publication date: March 2, 2023
    Applicant: Genentech, Inc.
    Inventors: Peter DRAGOVICH, Thomas PILLOW, Robert Anthony BLAKE, Ingrid WERTZ
  • TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER
    Publication number: 20210221821
    Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
    Type: Application
    Filed: March 10, 2021
    Publication date: July 22, 2021
    Applicant: Genentech, Inc.
    Inventors: Robert Anthony BLAKE, Peter DRAGOVICH, Lewis J. GAZZARD, Susan KAUFMAN, Tracy KLEINHEINZ, Thomas PILLOW, Steven T. STABEN, Binqing WEI