Abstract: A single-use scalpel blade remover (1) removes a blade (33) from a tang (32) of a scalpel (30) and captures it, in a single-handed operation. The remover (1) comprises a housing (2) having a detent (16), and an actuator (3) which is operatively juxtaposed with the housing (2) and moveable alongside the housing in a forward direction from a proximal position (whereat an opening is formed between the proximal ends of the actuator and the housing) to a distal position (whereat the detent (16) engages the proximal end of the actuator). The blade remover (1) also includes a cam-operated mechanism (14, 23, 20) for automatically separating the heel of the blade (33) from the tang (32) as the actuator (3) is moved to the distal position.