Abstract: A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (Tg) that is greater than or equal to ?70° C. and less than or equal to ?45° C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4×10?6 cm3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to ?45° C.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: The present invention is based, at least in part, on the identification of a pharmaceutical container formed, at least in part, of a glass composition which exhibits a reduced propensity to delaminate, i.e., a reduced propensity to shed glass particulates. As a result, the presently claimed containers are particularly suited for storage of pharmaceutical compositions and, specifically, a pharmaceutical solution comprising a pharmaceutically active ingredient, for example, HUMALOG (insulin lispro), HUMALOG MIX 75-25 (insulin lispro), HUMALOG MIX 50-50 (insulin lispro), HUMILIN 70-30 (insulin), HUMILIN N (insulin), HUMULIN R (insulin) or GEMZAR (gemcitabine).

Abstract: The present invention is based, at least in part, on the identification of a pharmaceutical container formed, at least in part, of a glass composition which exhibits a reduced propensity to delaminate, i.e., a reduced propensity to shed glass particulates. As a result, the presently claimed containers are particularly suited for storage of pharmaceutical compositions and, specifically, a pharmaceutical solution comprising a pharmaceutically active ingredient, for example, RITUXAN (rituximab), AVASTIN (Bevacizumab), LUCENTIS (Ranibizumab) or HERCEPTIN (trastuzumab).

Abstract: The present invention is based, at least in part, on the identification of a pharmaceutical container formed, at least in part, of a glass composition which exhibits a reduced propensity to delaminate, i.e., a reduced propensity to shed glass particulates. As a result, the presently claimed containers are particularly suited for storage of pharmaceutical compositions and, specifically, a pharmaceutical solution comprising a pharmaceutically active ingredient, for example, HUMIRA® (Adalimumab).

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

Abstract: The present disclosure relates to methods for improving myogenic differentiation capacity of a cell line or an immortalized cell line. For example, the present disclosure relates to methods of exposing an immortalized cell line (e.g., an immortalized fibroblast cell line) to culture media comprising signaling pathway agonists, antagonist, or a combination thereof in order to improve differentiation capacity. In another example, the present disclosure relates to methods of improving differentiation capacity of a cell line or an immortalized cell line where the method includes transforming an immortalized cell line with one or more myogenic regulatory factors and exposing the immortalized cell line to culture media comprising signaling pathway agonists, antagonists, or a combination thereof.

Abstract: A kick traffic signal switch includes a housing having a plurality of dowel retention plates, a micro switch connected to the housing via two micro switch dowels, a pressure plate movably connected to the housing, pressing of the pressure plate by a user causes activation of the micro switch; and a bottom plate connected to a rear face of the housing.

Abstract: A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.

Abstract: Techniques described herein relate to a method for performing telemetry services for composed information handling systems. The method includes obtaining, by a system control processor manager, a telemetry request associated with a composed information handling system from a user associated with a group; in response to obtaining the telemetry request: identifying a telemetry intent associated with the telemetry request; aggregating telemetry data based on the telemetry intent to obtain aggregated telemetry data; encrypting the aggregated telemetry data based on telemetry distribution information associated with the group to obtain encrypted aggregated telemetry data; and providing the encrypted aggregated telemetry data to the group.

Abstract: Techniques described herein relate to a method for managing telemetry services for composed information handling systems. The method includes obtaining, by a system control processor manager, a telemetry request associated with a composed information handling system from a user; in response to obtaining the telemetry request: identifying a transaction identifier associated with the telemetry request; identifying telemetry intent associated with the telemetry request; aggregating telemetry data based on the telemetry intent and a telemetry data map entry associated with the transaction identifier to obtain aggregated telemetry data; and providing the aggregated telemetry data to the user.

Abstract: Techniques described herein relate to a method for managing composed information handling systems. The method includes obtaining, by a system control processor manager, a composition request for a composed information handling system to perform a workflow; in response to obtaining the composition request: identifying a composed system blueprint associated with the workflow; making a first determination that there are first predictive analytics associated with the composed system blueprint; in response to the first determination: identifying a composed infrastructure associated with the composed system blueprint capable of performing the workflow based on telemetry data and the first predictive analytics; instantiating a composed information handling system using the composed infrastructure to service the composition request; and setting up telemetry services for the composed information handling system using an at least one control resource set.

Abstract: An elbow assembly for a patient interface includes a swivel component adapted to connect to a patient interface and an elbow component adapted to connect to an air circuit. The swivel component is coupled to the elbow component by a ball and socket joint and a hinge joint which allows the elbow component to pivot relative to the swivel component about a single axis.

Abstract: The presently disclosed subject matter relates to a method for characterizing a protein. The method can comprise disposing a protein in a digestion buffer; disposing a hydrolyzing agent inhibitor in the digestion buffer; passing the digestion buffer comprising said protein and said hydrolyzing agent inhibitor through a reaction chamber comprising at least one hydrolyzing agent, wherein said protein contacts said hydrolyzing agent in the presence of said inhibitor and is present in the chamber for a period of time (t) sufficient to produce protein fragments and provide digestion of said protein in the chamber, wherein the passing of the digestion buffer comprising the protein and the hydrolyzing agent inhibitor through the chamber is done at an adjustable flow rate; and performing multi-segment liquid chromatography tandem mass spectrometry (LC MS/MS) to characterize the protein.

Abstract: Techniques described herein relate to a method for using pipeline data for deploying workflows. The method may include determining that a pipeline testing trigger occurred for a workflow; decomposing a pipeline testing manifest of the workflow; generating a testing execution plan using the decomposed workflow; adding instrumentation to the testing execution plan; determining that the instrumented testing execution plan is valid; deploying computing devices within a CI/CD pipeline ecosystem for performing the instrumented testing execution plan; capturing deployment logs; initiating telemetry capture; executing pipeline testing of the workflow based on the instrumented testing execution plan; generating a pipeline deployment information set based on the pipeline testing; and providing the pipeline deployment information set to an orchestrator of a production device ecosystem.

Abstract: Techniques described herein relate to a method for optimizing workflow execution. The method may include receiving an event notification at a service controller, wherein the event notification is associated with a workflow deployed in a device ecosystem; performing, based on receiving the event notification, a workflow reconfiguration action comprising: providing a first workflow portion to a first platform controller in a first domain in the device ecosystem; transmitting a workflow reconfiguration action notification to a second platform controller in a second domain of the device ecosystem; identifying, by the second platform controller and in response to receiving the workflow reconfiguration action notification, a data transfer optimization action associated with data to be transmitted from the second domain to the first domain and used during execution of the first workflow portion; and transmitting the data from the second domain to the first domain using the data transfer optimization action.

Abstract: Devices, systems, and techniques to incorporate lighting effects into computer-generated graphics. In at least one embodiment, a virtual scene comprising a plurality of lights is rendered by randomly sampling a set of lights from among the plurality of lights prior to rendering a frame of graphics. A subset of the set of lights is selected and used to render pixels within one or more portions of the frame.

Abstract: A method for managing pool device resources, the method comprising obtaining, by a resource use manager, a plurality of data points, generating a resource prediction model based on the plurality of data points, and initiating access to a PCI bus device operating on a pool device using a virtual switch operating on a second pool device based on the resource prediction model.

Abstract: A drain assembly for installation in a shower floor, the drain assembly including a drain body including an upper surface defining a top side, and a lower surface opposite the upper surface defining a bottom side. The drain assembly also defines an aperture extending along an axis through the drain body between the upper surface and the lower surface and includes an outlet having a flange and an elongated body. When assembled, the elongated body is configured to extend below the lower surface of the drain body when the flange rests on the upper surface. The drain assembly also includes one or more fasteners configured to couple the outlet to the drain body to form a water-tight seal therebetween, where each of the one or more fasteners are accessible from the top side.

Abstract: Systems and methods for operating a tag system. The methods comprising: emitting a wireless signal from an antenna of the tag with a first signal characteristic when the tag is proximate to an active antenna modulation marker; changing an impedance of a sensor from a first impedance value to a second impedance value when the active antenna modulation marker is exposed to a stimulus; and emitting a wireless signal from the antenna of the tag with a second signal characteristic when the tag is proximate to the active antenna modulation marker and the sensor has the second impedance value.