Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing a first intravascular device having a distal portion with a concave side, inserting the first device into the vascular lumen, positioning the distal portion in the vascular wall, and orienting the concave side of the distal portion toward the vascular lumen.

Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion with a lumen extending therein; inserting the device into the vascular lumen; positioning the distal portion in the vascular wall; and directing the distal portion within the vascular wall.

Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a re-entry device, and re-entering the true vascular lumen.

Abstract: A method and system for referring to and binding to objects using a moniker object is provided. In preferred embodiments a moniker object contains information to identify linked source data and provides methods through which a program can bind to the linked source data. A binding method is provided that returns an instance of an interface through which the linked source data can be accessed. In a preferred embodiment, the moniker object provides other methods including a reducing method that returns a more efficient representation of the moniker object; equality and hash methods for comparing moniker objects; and inverse, common prefix, and relative-path-to methods for comparing and locating moniker objects from other moniker objects. Several implementations of a moniker object are provided. Each implementation is a moniker class and has a class identifier that identifies code to manage the moniker class.

Abstract: A method and system for referring to and binding to objects using a moniker object is provided. In preferred embodiments a moniker object contains information to identify linked source data and provides methods through which a program can bind to the linked source data. A binding method is provided that returns an instance of an interface through which the linked source data can be accessed. In a preferred embodiment, the moniker object provides other methods including a reducing method that returns a more efficient representation of the moniker object; equality and hash methods for comparing moniker objects; and inverse, common prefix, and relative-path-to methods for comparing and locating moniker objects from other moniker objects. Several implementations of a moniker object are provided. Each implementation is a moniker class and has a class identifier that identifies code to manage the moniker class.

Abstract: Devices and methods for detecting one or more symptoms of stroke, such as motor function deficits and cognitive function deficits. By way of example, not limitation, the present invention provides devices and methods for detecting various forms of hemiparesis, ataxia, aphasia, and/or dysarthria, which may be measured alone or in any combination.

Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.

Abstract: Devices and methods for compressing a patient's limb or limbs (e.g., legs or arms) for treating or preventing ailments due to compromised venous or lymphatic circulation of the limb. Exemplary embodiments include, but are not limited to, sub-atmospheric compression, micro-pneumatic compression, and active fabric compression devices and methods.

Abstract: Devices and methods for maintaining an open airway are described. Systems and methods are described for maintaining an opening of an airway by application of force to a patient's tissues in one of inferior, anterior, and lateral directions.

Abstract: Devices and methods for less invasively treating the gastrointestinal system, such as the intestinal mucosa of the small bowel. Embodiments described herein may be used to reduce caloric absorption and effectuate weight loss, for example.

Abstract: Using a message exchanger (“message exchanger”), data messages are exchanged between entities in a decentralized, distributed, potentially heterogeneous, network environment. The message exchanger employs XML (extensible Markup Language). To accomplish this, the entities on both ends of the message exchange understand, identify, and parse the message format. The message exchanger defines such a mechanism. Data messages are broken down into two portions—one portion (the body) is intended from an ultimate destination and the other portion (the header) is intended for intermediate destination and/or the ultimate destination. The body may be defined so that it must be understood by the ultimate destination. The header may be defined so that it must be understood or changed. Regardless, the data in the body is delivered intact to the ultimate destination. The message exchanger defines a message envelope exchange format in XML over a transport protocol, such as HTTP (HyperText Transport Protocol).

Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.

Abstract: The present invention allows for remotely and securely configuring settings for targeted devices within a network with multiple security-trust boundaries. Configuration information is encoded in messages that are digitally signed to ensure the integrity of the configuration information and sent in accordance with a standard messaging transport protocol. By utilizing an already existing port of the standard messaging transport protocol, e.g., SMTP, the number of open ports for configuration purposes is minimized. Further, example embodiments take advantage of hidden fields, i.e., machine readable fields that contain metadata that by default are not presented at a client user interface, for encoding the configuration or command/control information within the messages.

Abstract: The present invention allows for remotely and securely configuring settings for targeted devices within a network with multiple security-trust boundaries. Configuration information is encoded in messages that are digitally signed to ensure the integrity of the configuration information and sent in accordance with a standard messaging transport protocol. By utilizing an already existing port of the standard messaging transport protocol, e.g., SMTP, the number of open ports for configuration purposes is minimized. Further, example embodiments take advantage of hidden fields, i.e., machine readable fields that contain metadata that by default are not presented at a client user interface, for encoding the configuration or command/control information within the messages.

Abstract: The present invention provides for methods, systems, and computer program products for ensuring that sensitive subject matter within electronic messages is not inappropriately transferred between domains with differing security rights. The present invention utilizes the appropriate placement of message transfer agents or servers along with policy documents that include configurable semantics pattern recognition data for identifying deviant messages. Once deviant messages or messages that potentially have sensitive subject matter are identified, the present invention further provides for adaptable actions or remedies for ensuring that the sensitive subject matter is not inappropriately transferred between domains.

Abstract: Devices and methods for treating a damaged intervertebral disc to reduce or eliminate associated back pain. Dynamic bias devices and reinforcement devices are disclosed, which may be used individually or in combination, to eliminate nerve impingement associated with the damaged disc, and/or to reinforce the damaged disc, while permitting relative movement of the vertebrae adjacent the damaged disc.

Abstract: A group identifier represents an association between each of a number of different abbreviated namespace identifiers with a corresponding hierarchical namespace (e.g., an XML namespace). A hierarchically-structured document (e.g., an XML document) is accessed by a computing system that determines that the group identifier is associated with the hierarchically-structured document. Hence, when using the abbreviated namespace identifiers in the hierarchically-structured document, the computing system knows that the corresponding namespace is associated with the designated portions of the hierarchically-structured document. Also, a schema description language document (e.g., an XSD document) may specify multiple target namespaces for a single element. Accordingly, groupings of elements may be included in different namespaces to creating overlapping or even nested namespaces.

Abstract: The present invention utilizes honeypots, which are messaging system resources set up to attract unauthorized or illicit use thereof, for automatically identifying messages with malignant content. As messages are received at a honeypot, fingerprints of the messages are generated, which correspond to pattern information within the messages. These fingerprints are then used to determine a confidence level that messages received at a legitimate messaging service are malignant. Based on the confidence level, various actions (e.g., deleting the malignant content) may be executed.

Abstract: The present invention utilizes existing encapsulation or encoding mechanisms for embedding user profile information in electronic messages. Such information may then be distributed amid a community of users for which an individual, organization or other entity interact. The present invention takes advantage of hidden fields, i.e., machine readable fields that contain metadata that by default are not presented at client user interface, for including the user profile information. The user profiles may be stored in a repository of user profiles, wherein a recipient of the user profiles may subsequently query the repository using keywords for accessing desired information about individuals or organizations for which they interact with.

Abstract: The present invention extends to methods, systems, and computer program products for extending and optimizing electronic messaging rules. A messaging module automatically generates intermediate language instructions that represent messaging rules. The intermediate language instructions are decompiled into corresponding source code and modified to extend the functionality of the messaging rules. The modified source code is recompiled into modified intermediate language instructions that are executable by a rule execution module. A criteria evaluator identifies portions of intermediate language rule instructions that can be can be rewritten to facilitate more efficient rule execution. An intermediate language rewriter optimizes the identified portions of intermediate language rule instructions based on rule optimization data.