Abstract: A non-rechargeable, disposable hypodermic syringe for use with a needle includes a barrel, a retaining ring, and a plunger. The plunger has at least one annular notch formed therein. The barrel has at least one internal inwardly-flared tab formed therein which is oriented towards the forward end of the barrel. The tab is inwardly-biased, so that during rearward movement of the plunger, after delivery of the substance therein, the tab is received in the notch for annularly engaging in the notch, preventing the plunger's continued rearward movement and preventing the recharging of the syringe. In this manner, the syringe cannot be reused. The retaining ring is circumferentially disposed in the barrel between the plunger and the barrel. Cooperating ratchet teeth between the plunger and the ring coordinate the forward movement of the plunger with the ring, permitting the initial filling and aspiration of the syringe.