Patents by Inventor Robert B. BuBridge

Robert B. BuBridge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONSTRAINED CONDITIONALLY ACTIVATED BINDING PROTEINS
    Publication number: 20230414752
    Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.
    Type: Application
    Filed: July 21, 2023
    Publication date: December 28, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Chad May, Robert B. BuBridge, Maia Vinogradova, Anand Panchal