Patents by Inventor Robert B. Cary
Robert B. Cary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240077309Abstract: The present disclosure generally relates to displaying information related to a physical activity. In some embodiments, methods and user interfaces for managing the display of information related to a physical activity are described.Type: ApplicationFiled: January 12, 2023Publication date: March 7, 2024Inventors: Nicholas D. FELTON, James B. CARY, Edward CHAO, Kevin W. CHEN, Christopher P. FOSS, Eamon F. GILRAVI, Austen J. GREEN, Bradley W. GRIFFIN, Anders K. HAGLUNDS, Lori HYLAN-CHO, Stephen P. JACKSON, Matthew S. KOONCE, Paul T. NIXON, Robert M. PEARSON
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Publication number: 20240075473Abstract: A lateral flow assay device of the present disclosure has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The device also can have a gasket to ensure free air movement between open vent pockets. Flow control features that protrude horizontally into a chamber proximal to an outlet act to deflect the flow to the side of the chamber opposite from the outlet, prior to the flow entering the outlet. Such features can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enhance mixing of reagents with a sample, and enabling more accurate control of fluid flow in the device.Type: ApplicationFiled: September 2, 2022Publication date: March 7, 2024Inventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
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Publication number: 20240076724Abstract: An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction.Type: ApplicationFiled: September 2, 2022Publication date: March 7, 2024Inventors: Mark Nowakowski, Michael Wang, Robert B Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J Thomas
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Publication number: 20240033733Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess.Type: ApplicationFiled: June 21, 2023Publication date: February 1, 2024Inventors: Donald J. Thomas, Hong Cai, Robert B Cary
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Publication number: 20220145364Abstract: A disposable assay platform for detecting a target nucleic acid comprising multiple chambers and a method for operating the assay platform. Solutions containing the target nucleic acid move from one chamber to the next chamber by opening a vent pocket. The resulting pressure change enables the solution to flow to the next chamber. The platform comprises an electronic layer and one or more fluid layers bonded together. All heating operations can be performed by using resistive heating elements in the platform. All cooling operations are preferably passive. The platform is preferably operated when in a vertical orientation and can be docked to an external docking station that controls the operation of the platform.Type: ApplicationFiled: January 21, 2022Publication date: May 12, 2022Inventors: Marc DEJOHN, Robert B. CARY, Nathan J. COBB
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Patent number: 11268142Abstract: A disposable assay platform for detecting a target nucleic acid comprising multiple chambers and a method for operating the assay platform. Solutions containing the target nucleic acid move from one chamber to the next chamber by opening a vent pocket. The resulting pressure change enables the solution to flow to the next chamber. The platform comprises an electronic layer and one or more fluid layers bonded together. All heating operations can be performed by using resistive heating elements in the platform. All cooling operations are preferably passive. The platform is preferably operated when in a vertical orientation and can be docked to an external docking station that controls the operation of the platform.Type: GrantFiled: November 8, 2019Date of Patent: March 8, 2022Assignee: Mesa Biotech, Inc.Inventors: Marc Dejohn, Robert B. Cary, Nathan J. Cobb
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Publication number: 20200216876Abstract: A disposable assay platform for detecting a target nucleic acid comprising multiple chambers and a method for operating the assay platform. Solutions containing the target nucleic acid move from one chamber to the next chamber by opening a vent pocket. The resulting pressure change enables the solution to flow to the next chamber. The platform comprises an electronic layer and one or more fluid layers bonded together. All heating operations can be performed by using resistive heating elements in the platform. All cooling operations are preferably passive. The platform is preferably operated when in a vertical orientation and can be docked to an external docking station that controls the operation of the platform.Type: ApplicationFiled: November 8, 2019Publication date: July 9, 2020Inventors: Marc DEJOHN, Robert B. CARY, Nathan J. COBB
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Patent number: 10519492Abstract: A disposable assay platform for detecting a target nucleic acid comprising multiple chambers and a method for operating the assay platform. Solutions containing the target nucleic acid move from one chamber to the next chamber by opening a vent pocket. The resulting pressure change enables the solution to flow to the next chamber. The platform comprises an electronic layer and one or more fluid layers bonded together. All heating operations can be performed by using resistive heating elements in the platform. All cooling operations are preferably passive. The platform is preferably operated when in a vertical orientation and can be docked to an external docking station that controls the operation of the platform.Type: GrantFiled: April 20, 2012Date of Patent: December 31, 2019Assignee: Mesa Biotech, Inc.Inventors: Marc DeJohn, Robert B. Cary, Nathan J. Cobb
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Patent number: 10458978Abstract: The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the potential information capacity of the platform comparable to more traditional spotted fluorescence microarrays as well as improving sensitivity. The LFM devices exemplified herein enable analytes to be detected within 10 seconds from the time of sample introduction to the LFM device. Sample volumes may be as low as about 10 microliters, significantly reducing assay costs and ameliorating reagent storage logistics. Additionally, the miniaturization of lateral flow opens the door to highly multiplexed assays, allowing many proteins or nucleic acids to be detected in a single assay.Type: GrantFiled: February 13, 2017Date of Patent: October 29, 2019Assignee: Triad National Security, LLCInventor: Robert B. Cary
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Publication number: 20180304260Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Mesa Biotech, Inc.Inventors: Donald J. Thomas, Hong Cai, Robert B. Cary
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Patent number: 9944922Abstract: Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.Type: GrantFiled: December 8, 2015Date of Patent: April 17, 2018Assignee: Los Alamos National Security, LLCInventor: Robert B. Cary
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Publication number: 20170160271Abstract: The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the potential information capacity of the platform comparable to more traditional spotted fluorescence microarrays as well as improving sensitivity. The LFM devices exemplified herein enable analytes to be detected within 10 seconds from the time of sample introduction to the LFM device. Sample volumes may be as low as about 10 microliters, significantly reducing assay costs and ameliorating reagent storage logistics. Additionally, the miniaturization of lateral flow opens the door to highly multiplexed assays, allowing many proteins or nucleic acids to be detected in a single assay.Type: ApplicationFiled: February 13, 2017Publication date: June 8, 2017Inventor: Robert B. Cary
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Publication number: 20160310948Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers.Type: ApplicationFiled: April 25, 2016Publication date: October 27, 2016Inventors: Mark Nowakowski, Michael Wang, Robert B. Cary, Hong Cai, Conrad Lindberg, Martin Bouliane, Donald J. Thomas
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Publication number: 20160222442Abstract: The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the potential information capacity of the platform comparable to more traditional spotted fluorescence microarrays as well as improving sensitivity. The LFM devices exemplified herein enable analytes to be detected within 10 seconds from the time of sample introduction to the LFM device. Sample volumes may be as low as about 10 microliters, significantly reducing assay costs and ameliorating reagent storage logistics. Additionally, the miniaturization of lateral flow opens the door to highly multiplexed assays, allowing many proteins or nucleic acids to be detected in a single assay.Type: ApplicationFiled: February 1, 2016Publication date: August 4, 2016Inventor: Robert B. Cary
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Publication number: 20160083716Abstract: Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.Type: ApplicationFiled: December 8, 2015Publication date: March 24, 2016Inventor: Robert B. Cary
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Patent number: 9207236Abstract: Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.Type: GrantFiled: November 5, 2010Date of Patent: December 8, 2015Assignee: Los Alamos National Security, LLCInventor: Robert B. Cary
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Publication number: 20140045191Abstract: A disposable assay platform for detecting a target nucleic acid comprising multiple chambers and a method for operating the assay platform. Solutions containing the target nucleic acid move from one chamber to the next chamber by opening a vent pocket. The resulting pressure change enables the solution to flow to the next chamber. The platform comprises an electronic layer and one or more fluid layers bonded together. All heating operations can be performed by using resistive heating elements in the platform. All cooling operations are preferably passive. The platform is preferably operated when in a vertical orientation and can be docked to an external docking station that controls the operation of the platform.Type: ApplicationFiled: April 20, 2012Publication date: February 13, 2014Applicant: MESA TECH INTERNATIONAL, INC.Inventors: Marc DeJohn, Robert B. Cary, Nathan J. Cobb
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Publication number: 20110160090Abstract: The invention provides semiconductor nanocrystal-based lateral flow microarrays (SN-LFM), assays using SN-LFM, signal amplification strategies, optical detection devices for collecting data from SN-LFM assays, and integrated sample-to-answer SN-LFM assay/detection devices.Type: ApplicationFiled: May 5, 2009Publication date: June 30, 2011Applicant: LOS ALAMOS NATIONAL LABORATORYInventor: Robert B. Cary
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Publication number: 20110117540Abstract: Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.Type: ApplicationFiled: November 5, 2010Publication date: May 19, 2011Applicant: Los Alamos National LaboratoryInventor: Robert B. Cary
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Publication number: 20090047673Abstract: The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the potential information capacity of the platform comparable to more traditional spotted fluorescence microarrays as well as improving sensitivity. The LFM devices exemplified herein enable analytes to be detected within 10 seconds from the time of sample introduction to the LFM device. Sample volumes may be as low as about 10 microliters, significantly reducing assay costs and ameliorating reagent storage logistics. Additionally, the miniaturization of lateral flow opens the door to highly multiplexed assays, allowing many proteins or nucleic acids to be detected in a single assay.Type: ApplicationFiled: August 22, 2007Publication date: February 19, 2009Inventor: Robert B. Cary