Abstract: A device for treating tissue includes a helical needle extending about a longitudinal axis thereof from a distal tip to a proximal end and a control member extending longitudinally between a distal end releasably coupled to the proximal end of the helical needle and a proximal end which, when the helical needle is inserted into a body, remains outside the body, the control member configured such that rotation of the control member about the longitudinal axis rotates the helical needle to screw the helical needle distally into a target tissue.

Abstract: Surgical devices and methods used for invaginating tissue during, for example, an endoscopic fundoplication procedure, are disclosed. The device includes an elongated tube having a proximal end configured to extend outside of the body and a distal end configured to extend proximate the tissue to be invaginated, and a distal member coupled to the distal end of the tube. The distal member is configured to hold or grasp the tissue to be invaginated. The devices may include a protective distal sleeve.

Abstract: An articulating portion for an elongate medical device is disclosed. The articulating portion may include a plurality of segments movable relative to one another, and a plurality of hinges disposed between adjacent segments. The segments can be configured to bend at the hinges upon manipulation of a control member of the device. The segments and the hinges can also be a single continuous piece of material.

Abstract: Embodiments of the invention include an endoscope including multiple lumens for tissue acquisition and removal and related methods of use.

Abstract: The present disclosure pertain to methods of tissue approximation of a tissue opening in a tissue wall of a body lumen. The method comprises pushing a suitable device through the tissue wall near at least one edge of the opening and pulling opposing edges of the tissue opening nearer to one another or into contact with one another. Also described are devices and kits that are useful for approximation of a tissue opening in a tissue wall of a body lumen.

Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.

Abstract: A method for isolating a portion of a lung may include inserting a treatment device into an airway of a patient, and applying energy from the treatment device to a treatment site in the airway to at least partially occlude the airway to inhibit air from entering the airway distal to the treatment site.

Abstract: Embodiments of the invention include an endoscope including multiple lumens for tissue acquisition and removal and related methods of use.

Abstract: Medical devices and methods are disclosed. An example medical guidewire for accessing a body lumen along a biliary and/or pancreatic tract may include an elongated member having a distal end and a proximal end. The guidewire may include a movable distal tip positioned at the distal end of the elongated member. The guidewire may also include an electromechanical actuator for actuating movement of the distal tip. The actuation of the electromechanical actuator actuates movement of the adjustable distal tip and facilitates cannulation of one or more of a bile duct and a pancreatic duct.

Abstract: A system may include an introducer sheath including a retention member configured to anchor the introducer sheath in a natural body lumen having a wall. The system may also have an elongate member extending along a longitudinal axis through a working channel of the introducer sheath. Additionally, the system may have a manipulating portion coupled to a distal end of the elongate member. The manipulating portion may include at least one selectively actuatable member configured to transition between an undeployed configuration and a deployed configuration. In the undeployed configuration, the at least one actuatable member may extend substantially parallel to the longitudinal axis and in at least one position in the deployed configuration, the at least one actuatable member may extend radially outwardly from the longitudinal axis.

Abstract: A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

Abstract: The medical device may include an elongate member having a proximal end and a distal end, and a plurality of legs coupled to the distal end of the elongate member. The medical device may also include a moveable element distal to the distal end of the elongate member, disposed around the plurality of legs. The moveable element may be reciprocally moveable relative to the elongate member and plurality of legs between a first and second position. The plurality of legs may be in a collapsed configuration when the moveable element is in the first position, and may be in an expanded configuration when the moveable element is in the second position.

Abstract: The invention in certain aspects relates to a surgical fastener for fastening tissue segments having tissue surfaces. The fastener includes a first fastener member having a base and a piercing element connected to the base for piercing the tissue segments to be fastened, a second fastener member having an opening for receiving and retaining the piercing element of the first fastener member such that the tissue segments to be fastened are retained between the first and second fastening members, and means for promoting adhesion between the tissue surfaces. The invention also relates to related methods and devices for promoting adhesion of tissue segments and preventing fastener migration, especially in an endoscopic procedure for the treatment of GERD.

Abstract: A medical device for advancement over a guidewire includes a number of lumens therein including a working channel lumen, one or more control wire lumens, and a guidewire lumen. A flexible support within the device includes number of interlocking elements that resist longitudinal compression, transfer rotational torque, and can bend side to side. The flexible support also includes a slot that is aligned with the guidewire lumen. An outer jacket includes a perforation, slot, slit, or thinned area that is aligned with the slot in the support member and the guidewire lumen in order to allow a device such as a guidewire to be removed from the guidewire lumen and through the support member.

Abstract: Medical devices having one or more micropatterned surfaces (e.g., micropatterned coatings).

Abstract: Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.

Abstract: Embodiments of the invention include devices for obtaining tissue including a proximal actuator and a distal assembly having first and second end effectors. The first and second end effectors include the features of at least one element within the inner surface either of the first and second end effectors for aiding in the capture and retention of a targeted tissue sample.

Abstract: Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. Other tissue fastener embodiments include means for applying a substantially constant force on the tissue layers and/or means for adjusting a length of the connecting member between the first and second members.

Abstract: An articulating portion for an elongate medical device is disclosed. The articulating portion may include a plurality of segments movable relative to one another, and a plurality of hinges disposed between adjacent segments. The segments can be configured to bend at the hinges upon manipulation of a control member of the device. The segments and the hinges can also be a single continuous piece of material.

Abstract: Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. In other tissue fastener embodiments the connecting member has an elastic compressive spring force for applying a substantially constant force on the tissue layers for adjusting a length of the connecting member between the first and second members.