Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present invention relates to a CD20 binding antibody which is capable of depleting B cells, and a BLyS binding antibody which is capable of antagonizing BLyS, as a combination for use in the treatment of an autoimmune disorder. The invention also relates to dosages, duration of treatment and time lapses between administration of the CD20 binding antibody which is capable of depleting B cells, and the BLyS binding antibody which is capable of antagonizing BLyS.

Abstract: The present invention relates to a CD20 binding antibody which is capable of depleting B cells, and a BLyS binding antibody which is capable of antagonizing BLyS, as a combination for use in the treatment of an autoimmune disorder. The invention also relates to dosages, duration of treatment and time lapses between administration of the CD20 binding antibody which is capable of depleting B cells, and the BLyS binding antibody which is capable of antagonizing BLyS.

Abstract: The present invention relates to a CD20 binding antibody which is capable of depleting B cells, and a BLyS binding antibody which is capable of antagonizing BLyS, as a combination for use in the treatment of an autoimmune disorder. The invention also relates to dosages, duration of treatment and time lapses between administration of the CD20 binding antibody which is capable of depleting B cells, and the BLyS binding antibody which is capable of antagonizing BLyS.

Abstract: A method of removing, reducing or detoxifying organic pollutants from a fluid, water or air, by contacting the fluid with a photoreactive metal semiconductor material in the presence of ultraviolet light of a wavelength to activate the photoreactive material, is improved by simultaneously contacting the photoreactive material with a substance that accepts electrons and thus inhibits hole-electron recombination. Such substance will be such as to readily accept electrons either from the conduction band or from superoxide ions, and to rapidly dissociate into harmless products.

Abstract: A purifier for water or air removes, reduces or detoxifies organic pollutants therefrom by causing the fluid to contact a matrix having surfaces with which a fixed anatase (TiO.sub.2) or other photoreactive metal semiconductor material is bonded, in the presence of light of wavelength that will activate the material.

Abstract: A purifier for water or air removes, reduces or detoxifies organic pollutants therefrom by causing the fluid to contact a matrix having surfaces with which a fixed anatase (TiO.sub.2) or other photoreactive metal semiconductor material is bonded, in the presence of light of a wavelength that will activate the material.

Abstract: A purifier for water or air removes, reduces or detoxifies organic pollutants therefrom by causing the fluid to contact a matrix having surfaces with which a fixed anatase (TiO.sub.2) or other photoreactive metal semiconductor material is bonded, in the presence of light of a wavelength that will activate the material.

Abstract: Winding apparatus for continuously winding tape media upon reels contained within closed cartridges. The winding apparatus includes means for supplying cartridges alternatively to three separate in-line winding channels all of which perform a winding function and then collecting the wound cartridges off the individual lines and presenting an output station for a subsequent packing operation. Each channel includes vacuum extension means for reaching through an opening in each cartridge to apply an adhesive patch to the hub of the reel contained within the cartridge. Each line also includes means for continuously supplying tape media to a wind station for winding upon the reels passing through that line. At the wind station, additional vacuum means bring the leading edge of the media into the cartridge and press it against the adhesive patch, thereby attaching the media to the reel.