Abstract: Methods of treating cancer in patients in need thereof with human interleukin-18 (IL-18) polypeptides and substitution mutants thereof that are conjugated to water-soluble polymers at specific sites on the human IL-18 protein are disclosed.

Abstract: The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).

Abstract: Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.

Abstract: Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.

Abstract: A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease.

Abstract: Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

Abstract: A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease.

Abstract: Nucleic acid sequences for HC gp-39L is provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

Abstract: The invention relates to a method of diagnosing artherosclerosis by detecting mutation or altered expression of HC gp-39.

Abstract: Methods of screening for colorectal cancer by measuring levels of HC gp-39 are provided. Methods of monitoring patients with colorectal cancer are also provided. In addition, kits for detection of HC gp-39 useful in screening for and monitoring of colorectal cancer in a patient are provided.

Abstract: In refrigerator tractor/trailer vehicles, a data acquisition module is connected with one or more temperature sensors adapted for measurement of the temperatures within the trailer and may be connected with one or more distance sensors and "door open" sensors located in the trailer. Such a data acquisition module preferably comprises a microprocessor and random access memory connected with a plurality of sensors and adapted to acquire stored data on temperatures within the trailer and further connected with clock means to provide time data associated with the temperature data. In such systems, a control and display module, which comprises a separate portable control and display unit, can provide temperature data and distance data to the vehicle operator, warnings to the vehicle operator if the temperature of the trailer approaches unacceptable limits, warnings during backing of the trailer of impending collision with an object and warnings if the trailer doors are opened without authority.