Patents by Inventor Robert B. Meeley

Robert B. Meeley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12012605
    Abstract: Compositions and methods for obtaining plant cells with modified Ht1 nucleotide sequences, modified NLB18 sequences, or both, are provided herein. The methods involve introducing double-strand breaks into the maize genome in an endogenous Ht1 encoding sequence, an endogenous NLB18 encoding sequence, or both, to modify the genomic sequence in order to enhance northern leaf blight resistance of a plant produced from the plant cell. Further provided are methods that introduce resistant alleles of Ht1 and/or NLB18 into specific sites in the genome. Plants produced by the plant cells, and seeds produced from the plants are also included. Guide polynucleotides are also provided for the use of the CRISPR-Cas system in inducing double strand breaks.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 18, 2024
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Huirong Gao, Bailin Li, Robert B Meeley, Leandro Daniel Perugini, Girma M Tabor
  • Patent number: 11827894
    Abstract: The present disclosure involves the production of Waxy maize. Compositions and methods are provided for knocking out expression of the Waxy (Wx1) gene in maize by making double strand breaks at one or more target sites in an endogenous WX1 encoding sequence. Some methods employ one or more guide polynucleotides and a Cas endonuclease, wherein Cas endonuclease is guided by the one or more guide polynucleotides to recognize and introduce double strand breaks at specific target sites in and around the Wx1 gene. Also provided are compositions and methods for the production of Waxy maize plant cells, plant explants, seeds and grain.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: November 28, 2023
    Inventors: Andrew Mark Cigan, Mark Jacob Gadlage, Huirong Gao, Robert B Meeley, Joshua K Young
  • Publication number: 20230295650
    Abstract: The field is molecular biology, and more specifically, methods for chromosomal engineering of multiple native genes, such as disease resistance genes in a genomic locus using site-specific editing to produce plants. Also described herein are methods of generating heterologous genomic locus in a plant that comprises a plurality of intraspecies polynucleotide sequences.
    Type: Application
    Filed: August 17, 2021
    Publication date: September 21, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY J. FRANK, HUIRONG GAO, JEFFREY HABBEN, SABRINA HUMBERT, NANDINI KRISHNAMURTHY, MICHAEL LASSNER, BAILIN LI, ROBERT B. MEELEY, LEANDRO DANIEL PERUGINI, GIRMA TABOR, PETRA J. WOLTERS
  • Publication number: 20220346341
    Abstract: Methods and compositions for modulating plant meristems. Methods are provided for modulating fea3 and/or Fcp1 genomic locus in a host plant or plant cell to improve agronomic characteristics such as kernel number.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 3, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HUIRONG GAO, ZHENGLIN HOU, ROBERT B MEELEY
  • Publication number: 20220275392
    Abstract: Compositions and methods for obtaining plant cells with modified Ht1 nucleotide sequences, modified NLB18 sequences, or both, are provided herein. The methods involve introducing double-strand breaks into the maize genome in an endogenous Ht1 encoding sequence, an endogenous NLB18 encoding sequence, or both, to modify the genomic sequence in order to enhance northern leaf blight resistance of a plant produced from the plant cell. Further provided are methods that introduce resistant alleles of Ht1 and/or NLB18 into specific sites in the genome. Plants produced by the plant cells, and seeds produced from the plants are also included. Guide polynucleotides are also provided for the use of the CRISPR-Cas system in inducing double strand breaks.
    Type: Application
    Filed: October 10, 2017
    Publication date: September 1, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HUIRONG GAO, BAILIN LI, ROBERT B MEELEY, LEANDRO DANIEL PERUGINI, GIRMA M TABOR
  • Publication number: 20220162628
    Abstract: The present disclosure involves the production of Waxy maize. Compositions and methods are provided for knocking out expression of the Waxy (Wx1) gene in maize by making double strand breaks at one or more target sites in an endogenous WX1 encoding sequence. Some methods employ one or more guide polynucleotides and a Cas endonuclease, wherein Cas endonuclease is guided by the one or more guide polynucleotides to recognize and introduce double strand breaks at specific target sites in and around the Wx1 gene. Also provided are compositions and methods for the production of Waxy maize plant cells, plant explants, seeds and grain.
    Type: Application
    Filed: September 2, 2021
    Publication date: May 26, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ANDREW MARK CIGAN, MARK JACOB GADLAGE, HUIRONG GAO, ROBERT B MEELEY, JOSHUA K YOUNG
  • Publication number: 20220056470
    Abstract: The field is molecular biology, and more specifically, methods for chromosomal engineering of multiple native genes, such as disease resistance genes in a genomic locus using site-specific editing to produce plants. Also described herein are methods of generating heterologous genomic locus in a plant that comprises a plurality of intraspecies polynucleotide sequences.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 24, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY J FRANK, HUIRONG GAO, JEFFREY HABBEN, SABRINA HUMBERT, NANDINI KRISHNAMURTHY, MICHAEL LASSNER, BAILIN LI, ROBERT B MEELEY, LEANDRO DANIEL PERUGINI, GIRMA M TABOR, PETRA J WOLTERS
  • Publication number: 20220030788
    Abstract: The field is molecular biology, and more specifically, methods for editing the genome of a plant cell to identify causal alleles of a desired trait or to fine map a desired trait to small region of the genome for gene identification.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 3, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: SABRINA HUMBERT, MARK TIMOTHY JUNG, ZHAN-BIN LIU, ROBERT B MEELEY, BO SHEN, MARISSA SIMON, PETRA J WOLTERS
  • Publication number: 20210310018
    Abstract: The present invention provides polynucleotides and related polypeptides of the class of genes involved in maize secondary wall (ZmSCW) formation. The invention provides genomic sequence for the ZmSCW genes. ZmSCW are responsible for controlling plant growth, secondary cell wall development and yield in crop plants.
    Type: Application
    Filed: August 2, 2012
    Publication date: October 7, 2021
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: Kanwarpal S. Dhugga, Robert B. Meeley, Carl R. Simmons
  • Patent number: 11136589
    Abstract: The present disclosure involves the production of Waxy maize. Compositions and methods are provided for knocking out expression of the Waxy (Wx1) gene in maize by making double strand breaks at one or more target sites in an endogenous WX1 encoding sequence. Some methods employ one or more guide polynucleotides and a Cas endonuclease, wherein Cas endonuclease is guided by the one or more guide polynucleotides to recognize and introduce double strand breaks at specific target sites in and around the Wx1 gene. Also provided are compositions and methods for the production of Waxy maize plant cells, plant explants, seeds and grain.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: October 5, 2021
    Inventors: Andrew Mark Cigan, Mark Jacob Gadlage, Huirong Gao, Robert B Meeley, Joshua K Young
  • Publication number: 20200199609
    Abstract: Methods and compositions to modulate plant stature including plant height, ear height, planting density and other agronomic characteristics are disclosed. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, plants and seeds exhibiting altered stature characteristics or produce plants that exhibit altered stature parameters.
    Type: Application
    Filed: July 31, 2018
    Publication date: June 25, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HUIRONG GAO, SABRINA HUMBERT, SHUPING JIAO, ROBERT B MEELEY, DILBAG S MULTANI, XIAOMU NIU, JOAN MARIE PHILLIPS
  • Publication number: 20200168299
    Abstract: Systems and methods are described for designing nucleotide guides for site-specific genome editing that also minimize off-target genome edits. Systems and methods are described for using these nucleotide guides to edit specific genomic regions and minimize edits to genomic regions not intended for editing.
    Type: Application
    Filed: July 27, 2018
    Publication date: May 28, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ANDREW BAUMGARTEN, JUSTIN P GERKE, HUI GUO, MATTHEW G KING, HAINING LIN, ROBERT B MEELEY, BROOKE PETERSON-BURCH, YUN ZHANG
  • Publication number: 20190032070
    Abstract: The present disclosure involves the production of Waxy maize. Compositions and methods are provided for knocking out expression of the Waxy (Wx1) gene in maize by making double strand breaks at one or more target sites in an endogenous WX1 encoding sequence. Some methods employ one or more guide polynucleotides and a Cas endonuclease, wherein Cas endonuclease is guided by the one or more guide polynucleotides to recognize and introduce double strand breaks at specific target sites in and around the Wx1 gene. Also provided are compositions and methods for the production of Waxy maize plant cells, plant explants, seeds and grain.
    Type: Application
    Filed: January 25, 2017
    Publication date: January 31, 2019
    Applicant: Pioneer HIi-Bred International, Inc.
    Inventors: Andrew Mark CIGAN, Mark Jacob GADLAGE, Huirong GAO, Robert B MEELEY, Joshua K YOUNG
  • Publication number: 20170183671
    Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a PRE2 polypeptide.
    Type: Application
    Filed: July 14, 2016
    Publication date: June 29, 2017
    Inventors: Stephen M. Allen, Rajeev Gupta, Shuping Jiao, Robert B Meeley, Dilbag S Multani, Robert W Williams
  • Patent number: 9422572
    Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a PRE2 polypeptide.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: August 23, 2016
    Assignees: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Stephen M Allen, Rajeev Gupta, Shuping Jiao, Robert B Meeley, Dilbag S Multani, Robert Williams
  • Publication number: 20130326720
    Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments for altering root structure during plant development are disclosed along with methods of root structure alteration during plant development.
    Type: Application
    Filed: August 12, 2013
    Publication date: December 5, 2013
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC, E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Robert B Meeley, Xiaomu Niu, Hajime Sakai, Graziana Taramino
  • Patent number: 8546646
    Abstract: The present invention is directed to compositions and methods for altering the levels of seed proteins in cereal grain. The invention is directed to the alteration of seed protein levels in plant grain, resulting in grain with increased digestibility/nutrient availability, improved amino acid composition/nutritional value, increased response to feed processing, improved silage quality, and increased efficiency of wet milling.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 1, 2013
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Rudolf Jung, Wang-Nan Hu, Robert B Meeley, Vincent J. H. Sewalt, Ramesh Nair
  • Publication number: 20130232642
    Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a PRE2 polypeptide.
    Type: Application
    Filed: June 27, 2012
    Publication date: September 5, 2013
    Inventors: Stephen M. Allen, Rajeev Gupta, Shuping Jiao, Robert B. Meeley, Dilbag S. Multani, Robert Williams
  • Publication number: 20130022707
    Abstract: The present invention is directed to compositions and methods for altering the levels of seed proteins in cereal grain. The invention is directed to the alteration of seed protein levels in plant grain, resulting in grain with increased digestibility/nutrient availability, improved amino acid composition/nutritional value, increased response to feed processing, improved silage quality, and increased efficiency of wet milling.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 24, 2013
    Applicant: Pioneer Hi Bred International, Inc.
    Inventors: Rudolf Jung, Wang-Nan Hu, Robert B. Meeley, Vincent J.H. Sewalt, Ramesh Nair
  • Patent number: 8288614
    Abstract: The present invention is directed to compositions and methods for altering the levels of seed proteins in cereal grain. The invention is directed to the alteration of seed protein levels in plant grain, resulting in grain with increased digestibility/nutrient availability, improved amino acid composition/nutritional value, increased response to feed processing, improved silage quality, and increased efficiency of wet milling.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: October 16, 2012
    Assignee: Pioneer Hi Bred International, Inc
    Inventors: Rudolf Jung, Wang-Nan Hu, Robert B. Meeley, Vincent J.H. Sewalt, Ramesh Nair