Abstract: Provided herein according to some aspects is a method for processing a tissue sample from a subject, the sample comprising cells of a breast tissue site comprising or suspected of comprising ductal carcinoma in situ (DCIS), and detecting an expression level of a plurality of genes in the cells. Also provided according to some aspects is a method for generating a classifier capable of determining a risk of DCIS recurrence and/or progression. Further provided is a system for determining the risk of DCIS recurrence and/or progression in a subject in need thereof.

Abstract: Compositions and methods are provided for stratification of ductal carcinoma in situ (DCIS) tumors with respect to prognostic features that distinguish primary DCIS tumors with a high probability of recurrence and invasive disease, representing tumor progression, from tumors that will not recur. Stratification methods may comprise analysis of a DCIS tissue sample with MIBI-TOF imaging.

Abstract: A catheter device for creating linear lesions in endocardial tissue or other body tissue is described. The catheter includes an inner shaft telescopically received within an outer shaft. The inner shaft has one or more spaced apart electrodes along its distal section. The outer shaft member includes a fluid permeable window positionable to selectively overlay some or all of the electrodes when the relative positioning of the inner and outer shaft members is adjusted. During use, the window is positioned adjacent to the body tissue which is to be ablated and at least a portion of the electrodes are exposed through the window. RF energy is delivered to the electrodes while saline or other conductive fluid is simultaneously delivered through the infusion tube.