Patents by Inventor Robert B. Wilson
Robert B. Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230023267Abstract: The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.Type: ApplicationFiled: November 12, 2020Publication date: January 26, 2023Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of PhiladelphiaInventors: Amos SMITH, Robert B. WILSON, Donna M Huryn, Maria Grazia Cotticelli, Shujuan XIA, Taehee LEE, Roberto FORESTIERI
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Patent number: 11371041Abstract: This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: GrantFiled: April 15, 2019Date of Patent: June 28, 2022Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Yongping Wang
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Publication number: 20210198244Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: ApplicationFiled: August 7, 2020Publication date: July 1, 2021Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. WILSON, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos SMITH, Jason E. Melvin, Donna M. Huryn
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Patent number: 10745390Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: GrantFiled: June 2, 2017Date of Patent: August 18, 2020Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M Huryn
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Publication number: 20200040327Abstract: This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: ApplicationFiled: April 15, 2019Publication date: February 6, 2020Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Yongping WANG
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Patent number: 10260065Abstract: This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: GrantFiled: August 5, 2014Date of Patent: April 16, 2019Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Yongping Wang
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Publication number: 20190083470Abstract: The invention provides p38 MAPK inhibitors that compensate for a frataxin deficiency or mutation and methods of using the same (e.g., to treat Friedreich's ataxia).Type: ApplicationFiled: March 23, 2016Publication date: March 21, 2019Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: Robert B. Wilson
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Patent number: 10028518Abstract: The systems and methods of the present invention provide an economically feasible means of thermally processing items such as food products. In some embodiments, the thermal process is a pasteurization process. In other embodiments, the thermal process is a sterilization process. The thermal process utilizes a volumetric heating process to quickly and efficiently add heat energy to the item and then utilizes a surface heating process to obtain a relatively even, highly elevated, temperature throughout the item. In this way, the time required to perform various thermal processes, such as pasteurization and/or sterilization, is greatly reduced compared with traditional processes while still being more reliable and more predictable than other recently developed processes. Furthermore, the system and method is less complicated and more efficient than other systems and processes currently known. Furthermore still, the method includes spraying fluid onto a surface of the item to reduce edge heating.Type: GrantFiled: November 24, 2015Date of Patent: July 24, 2018Inventor: Robert B. Wilson
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Patent number: 9982256Abstract: This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: GrantFiled: October 19, 2015Date of Patent: May 29, 2018Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Yongping Wang
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Publication number: 20170334890Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: ApplicationFiled: June 2, 2017Publication date: November 23, 2017Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos SMITH, Jason E. Melvin, Donna M. Huryn
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Patent number: 9695157Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: GrantFiled: April 6, 2015Date of Patent: July 4, 2017Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M Huryn
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Publication number: 20160177294Abstract: This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: ApplicationFiled: August 5, 2014Publication date: June 23, 2016Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Robert B. WILSON, Yongping WANG
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Publication number: 20160143342Abstract: The systems and methods of the present invention provide an economically feasible means of thermally processing items such as food products. In some embodiments, the thermal process is a pasteurization process. In other embodiments, the thermal process is a sterilization process. The thermal process utilizes a volumetric heating process to quickly and efficiently add heat energy to the item and then utilizes a surface heating process to obtain a relatively even, highly elevated, temperature throughout the item. In this way, the time required to perform various thermal processes, such as pasteurization and/or sterilization, is greatly reduced compared with traditional processes while still being more reliable and more predictable than other recently developed processes. Furthermore, the system and method is less complicated and more efficient than other systems and processes currently known. Furthermore still, the method includes spraying fluid onto a surface of the item to reduce edge heating.Type: ApplicationFiled: November 24, 2015Publication date: May 26, 2016Inventor: Robert B. Wilson
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Publication number: 20160032283Abstract: This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: ApplicationFiled: October 19, 2015Publication date: February 4, 2016Inventors: Robert B. WILSON, Yongping Wang
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Patent number: 9163185Abstract: The invention provides methods and apparatus ultimately for converting a carbonaceous material to liquid hydrocarbons suitable for use, for example, as transportation fuels. In a first step the carbonaceous material is converted to a syngas product, and in subsequent steps the syngas product is converted to the desired liquid hydrocarbons. In one embodiment, coal and methane are converted to syngas, and the syngas product is converted to hydrocarbons through a methanol intermediate. An example use for the methods and apparatus of the invention is in the preparation of aviation fuels.Type: GrantFiled: August 28, 2013Date of Patent: October 20, 2015Assignee: SRI INTERNATIONALInventors: Daniel Steele, Robert B. Wilson, Ripudaman Malhotra, Brian Adair
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Patent number: 9163231Abstract: This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.Type: GrantFiled: March 6, 2007Date of Patent: October 20, 2015Assignee: The Trustees of the University of PennsylvaniaInventors: Robert B. Wilson, Yongping Wang
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Publication number: 20150210674Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: ApplicationFiled: April 6, 2015Publication date: July 30, 2015Inventors: Robert B. WILSON, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M. Huryn
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Patent number: 9000009Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: GrantFiled: December 10, 2009Date of Patent: April 7, 2015Assignee: The Trustees Of The University Of PennsylvaniaInventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M Huryn
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Publication number: 20150060335Abstract: The invention provides methods and apparatus ultimately for converting a carbonaceous material to liquid hydrocarbons suitable for use, for example, as transportation fuels. In a first step the carbonaceous material is converted to a syngas product, and in subsequent steps the syngas product is converted to the desired liquid hydrocarbons. In one embodiment, coal and methane are converted to syngas, and the syngas product is converted to hydrocarbons through a methanol intermediate. An example use for the methods and apparatus of the invention is in the preparation of aviation fuels.Type: ApplicationFiled: August 28, 2013Publication date: March 5, 2015Applicant: SRI International, Inc.Inventors: Daniel Steele, Robert B. Wilson, Ripudaman Malhotra, Brian Adair
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Publication number: 20120041023Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.Type: ApplicationFiled: December 10, 2009Publication date: February 16, 2012Inventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M Huryn