Patents by Inventor Robert Baffi

Robert Baffi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of synthesizing tetrahydrobiopterin
    Patent number: 8178670
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin of Formula I in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: May 15, 2012
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Müller, Philipp Schmidt, Stefan Kaiser
  • Stable tablet formulation
    Patent number: 8003126
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: August 23, 2011
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi
  • METHOD OF SYNTHESIZING TETRAHYDROBIOPTERIN
    Publication number: 20090198055
    Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.
    Type: Application
    Filed: January 6, 2009
    Publication date: August 6, 2009
    Applicant: BioMarin Pharmaceutical Inc.
    Inventors: Mark Henderson, Steven Jungles, Gabriele Roidl, Robert Baffi, Adriano Indolese, Christian Muller, Philipp Schmidt, Stefan Kaiser
  • Stable tablet formulation
    Patent number: 7566462
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: July 28, 2009
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark A. Henderson, Victoria Sluzky, Robert Baffi
  • STABLE TABLET FORMULATION
    Publication number: 20080207626
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Application
    Filed: April 21, 2008
    Publication date: August 28, 2008
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi
  • Stable Tablet Formulation
    Publication number: 20070270581
    Abstract: The present invention is directed to a stable solid formulations of tetrahydrobiopterin, processes for producing them, and treatment methods using such formulations.
    Type: Application
    Filed: November 16, 2005
    Publication date: November 22, 2007
    Applicant: Biomarin Pharmaceutical Inc.
    Inventors: Steven Jungles, Mark Henderson, Victoria Sluzky, Robert Baffi