Patents by Inventor Robert Bahde

Robert Bahde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective synthesis and process for the manufacturing of 2?-deoxynucleosides
    Patent number: 11365211
    Abstract: Methods for stereoselective synthesis and manufacturing of 2?-deoxynucleosides, such as 2?-ribonucleosides, are disclosed. In some embodiments, the 2?-deoxynucleoside is a ?-anomer of a 2?-deoxynucleoside having a 3? ? hydroxyl, 4? ? hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4?-thio-2?-deoxycytidine (T-dCyd) and 5-aza-4?-thio-2?-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 21, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Lianhao Zhang, Baburao Vishnuvajjala, Joel Morris, Robert Bahde, Sergiy M. Denysenko, Omar Diego Lopez, Donn Gregory Wishka
  • STEREOSELECTIVE SYNTHESIS AND PROCESS FOR THE MANUFACTURING OF 2'-DEOXYNUCLEOSIDES
    Publication number: 20200361977
    Abstract: Methods for stereoselective synthesis and manufacturing of 2?-deoxynucleosides, such as 2?-ribonucleosides, are disclosed. In some embodiments, the 2?-deoxynucleoside is a ?-anomer of a 2?-deoxynucleoside having a 3? ? hydroxyl, 4? ? hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4?-thio-2?-deoxycytidine (T-dCyd) and 5-aza-4?-thio-2?-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
    Type: Application
    Filed: January 30, 2019
    Publication date: November 19, 2020
    Applicants: The USA, as represented by the Secretary, Department of Health and Human Services, Alchem Laboratories Corporation
    Inventors: Lianhao Zhang, Baburao Vishnuvajjala, Joel Morris, Robert Bahde, Sergiy M. Denysenko, Omar Diego Lopez, Donn Gregory Wishka