Abstract: A multi-photon microscope has an illumination source, an objective lens unit arranged in an optical path of the illumination source, a first light collection system arranged to collect a first portion of light emitted from a sample when the sample is illuminated by light from the illumination source, and a second light collection system arranged to collect a second portion of light emitted from the sample when the sample is illuminated by light from the illumination source. The first portion of light when collected by the first light collection system and the second portion of light when collected by the second light collection system, together provide a means of collecting as much light from as many angles as possible emanating from an emitting point source. This collection scheme has the potential to approach the total emission collection of light from an emitting point source depending on the optical properties of the sample being imaged.

Abstract: A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contrast agents can be used to practice the present method including, without limitation, sugars, amino acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.

Abstract: A computer programmed to represent a spreadsheet that can be displayed to a user, the spreadsheet including an array of cells for storing user entered data, the programmed computer including programmed logic for designating a group of one or more cells within the spreadsheet, the group of one or more cells containing a first set of user entered data; programmed logic for creating an alternative for the group of one or more cells, said alternative containing a second set of user entered data that is different from the first set of user entered data; and programmed logic for enabling the user to select between the group of one or more cells and the alternative as the source of the data that is used in a corresponding group of cells within the spreadsheet.