Patents by Inventor Robert Barish

Robert Barish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10041108
    Abstract: This disclosure provides methods for generating super-resolution patterns of molecules on substrates. In one aspect, disclosed herein is a method comprising contacting a plurality of transiently binding nucleic acid probes to their respective targets wherein the targets are immobilized on a substrate, detecting a binding event in a select region or set of select regions within a diffraction limited region of the substrate, and irradiating the diffraction limited region of the substrate, wherein the probes comprise a photocrosslinker. In one embodiment, the photocrosslinker is 3-cyanovinylcarbazole.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: August 7, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Robert Barish, Peng Yin
  • Publication number: 20160312272
    Abstract: This disclosure provides methods for generating super-resolution patterns of molecules on substrates. In one aspect, disclosed herein is a method comprising contacting a plurality of transiently binding nucleic acid probes to their respective targets wherein the targets are immobilized on a substrate, detecting a binding event in a select region or set of select regions within a diffraction limited region of the substrate, and irradiating the diffraction limited region of the substrate, wherein the probes comprise a photocrosslinker. In one embodiment, the photocrosslinker is 3-cyanovinylcarbazole.
    Type: Application
    Filed: December 15, 2014
    Publication date: October 27, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Robert Barish, Peng Yin
  • Publication number: 20160033411
    Abstract: This disclosure provides methods for generating super-resolution patterns of molecules on substrates.
    Type: Application
    Filed: July 28, 2015
    Publication date: February 4, 2016
    Applicant: President and Fellows of Harvard College
    Inventor: Robert Barish
  • Publication number: 20140141211
    Abstract: The present invention relates to methods for self-assembly of arbitrarily-shaped metal nanostructures using specifically-designed patterns on nucleic acid scaffolds. The methods involve using the nucleic acid scaffolds as templates on which a second material patterned, as seed nuclei. The patterns are then selectively plated with metal using an electro-less plating process to create arbitrarily-shaped metal nanostructures that are not constrained by the structure of the scaffold. The methods herein use controlled-growth processes to actively select the dimensions, positions, and alignments of the patterns to create different arbitrary shapes of metal nanostructures.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 22, 2014
    Inventors: Si-Ping Han, Robert Barish, Michael J. Hochberg, Saurabh Vyawahare, Hareem Maune
  • Patent number: 6403938
    Abstract: A system and method for facilitating microwave heating of a liquid includes the use of a generally cylindrical holder for receiving the liquid to be heated. A shielding sleeve at least partially composed of high microwave reflectivity material, blocks microwave energy from entering a selected interior portion only of the holder to prevent direct microwave heating of the liquid in the selected portion. As a result, there are shielded and unshielded portions of the liquid being heated to cause the liquid to be heated to a substantially uniform temperature throughout the liquid being heated. A mechanism enables the sleeve to be positioned such that the blocking portion of the sleeve is positioned at or above the level of the liquid disposed within the interior of the holder so that the top layer of the liquid is shielded from direct microwave heating to prevent unwanted super heating of a portion of the liquid and thus causing hot spots.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: June 11, 2002
    Assignee: Medical Indicators, Inc.
    Inventors: Robert J. Witonsky, John W. Scarantino, John C. Estill, Ronald M. Benincasa, Robert A. Barish
  • Publication number: 20010042748
    Abstract: A system and method for facilitating microwave heating of a liquid includes the use of a generally cylindrical holder for receiving the liquid to be heated. A shielding sleeve at least partially composed of high microwave reflectivity material, blocks microwave energy from entering a selected interior portion only of the holder to prevent direct microwave heating of the liquid in the selected portion. As a result, there are shielded and unshielded portions of the liquid being heated to cause the liquid to be heated to a substantially uniform temperature throughout the liquid being heated. A mechanism enables the sleeve to be positioned such that the blocking portion of the sleeve is positioned at or above the level of the liquid disposed within the interior of the holder so that the top layer of the liquid is shielded from direct microwave heating to prevent unwanted super heating of a portion of the liquid and thus causing hot spots.
    Type: Application
    Filed: June 25, 2001
    Publication date: November 22, 2001
    Inventors: Robert J. Witonsky, John W. Scarantino, John C. Estill, Ronald M. Benincasa, Robert A. Barish
  • Patent number: 4728210
    Abstract: A solid personal care product is packaged in a container having a cover and handle, with the personal care product being attached to a gripping plate on the cover for removal from the container with the cover. The gripping plate preferably includes a porous member which is impregnated with a portion of the solid product to firmly grip the solid product for removal with the cover.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: March 1, 1988
    Assignee: Carter-Wallace, Inc
    Inventors: Robert A. Barish, Frederick G. Searby
  • Patent number: 3967756
    Abstract: A bottom loading dispensing container for liquid impregnated wipes is disclosed. The top and sides of the container are a single molded plastic element. The top has an opening in its center which is sealed by a removable lid. The container is sealed at the bottom with a liquid impervious element which element may be constructed to add increased dimensional stability to the container.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: July 6, 1976
    Assignee: Johnson & Johnson
    Inventor: Robert A. Barish
  • Patent number: D244583
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: June 7, 1977
    Assignee: Johnson & Johnson
    Inventor: Robert A. Barish
  • Patent number: D306562
    Type: Grant
    Filed: February 25, 1988
    Date of Patent: March 13, 1990
    Assignee: Carter-Wallace, Inc.
    Inventors: Robert A. Barish, Frederick G. Searby