Patents by Inventor Robert Barthel

Robert Barthel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF ASSESSING THE SENSITIVITY OR RESISTANCE OF A SUBJECT TO AN ONCOLYTIC VIRUS, RECOMBINANT VIRUS, PREPARATION AND USES THEREOF
    Publication number: 20220356529
    Abstract: The present invention relates to the field of medicine and in particular to the treatment of cancer. More particularly, the invention relates to a method of assessing the sensitivity or resistance of a subject having a cancer to an oncolytic virus, to a method of selecting a treatment comprising an oncolytic virus efficient against the cancer of a subject and to a method of monitoring in a subject the response to a cancer treatment comprising an oncolytic virus. The description further relates to products including a therapeutic recombinant virus, in particular a recombinant oncolytic virus, typically a vaccinia virus, a pharmaceutical composition, and a kit comprising such a therapeutic virus, as well as preparation and uses thereof.
    Type: Application
    Filed: July 16, 2020
    Publication date: November 10, 2022
    Inventors: BÉATRICE CAMBIEN, GEORGES VASSAUX, ROBERT BARTHEL
  • Process for obtaining myofibroblasts
    Patent number: 9243228
    Abstract: The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: January 26, 2016
    Assignee: Oncobiotek SA
    Inventors: Nicolas Jacques Rouyer, Robert Barthel
  • Process for Obtaining Myofibroblasts
    Publication number: 20120190109
    Abstract: The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.
    Type: Application
    Filed: July 2, 2010
    Publication date: July 26, 2012
    Inventors: Nicolas Jacques Rouyer, Robert Barthel