Abstract: Provided herein are single guide RNAs (sgRNAs) that comprise aptamer sequences and related compositions and methods. Also provided herein are methods of selecting inducible sgRNAs that comprise aptamer sequences.

Abstract: Methods and uses for treating cancer in a subject are provided. In particular, the present disclosure provides methods and uses relating to treating a subject with cancer by activating human mitochondrial CIpP (HsCIpP). The present disclosure further provides methods and uses of an acyldepsipeptide (ADEP) analog that activates HsCIpP in the subject in need thereof.

Abstract: A steel sided double-walled bottom fed sawdust, woodchip and other particulate matter burning furnace where combustion air is pre-heated by passing around the combustion area between the double walls and further having an automatic fuel shut-off feature.

Abstract: A compact low-maintenance moving air modular cabinet wood particles/sawdust dryer having a serpentine path for heated air to move injected wood particles/sawdust through the cabinet, drying it as it goes, together with a system for providing controllable heated airflow and a regulated supply of wood particles/sawdust to be dried.

Abstract: Embodiments herein provide for lysine riboswitches and analogs thereof, and methods for using the same. In certain embodiments, test compounds are identified that associate with lysine riboswitches. In other embodiments, test compounds found to associate with lysine can be used to increase or decrease gene expression of Gram-negative bacterial organisms.

Abstract: The application relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In particular, the application relates to compositions and methods for treating the hematological malignancies acute myeloid leukemia (AML), lymphoma and multiple myeloma (MM) using 5-nitrogen substituted hydroxy quinolones as well as 7-bromo-5-chloro substituted hydroxy quinolones and 5-chloro substituted hydroxy quinolones.

Abstract: Embodiments of the present invention provide for SAM-II riboswitches and analogs thereof, and methods for using the same. In certain embodiments of the present invention, test compounds are identified that associate with SAM-II riboswitches. In other embodiments, test compounds found to associate with SAM II can be used to increase or decrease gene expression of Gram-negative bacterial organisms.

Abstract: Riboswitches and modified versions of riboswitches can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.

Abstract: Embodiments of the present invention provide for SAM-I riboswitches and analogs thereof, and methods for using the same. In certain embodiments of the present invention, test compounds are identified that associate with SAM-I riboswitches.

Abstract: Activatable ribozymal purification constructs are used to rapidly and efficiently purify RNA, including non-denatured RNA. The activatable ribozymal purification construct includes an activatable ribozyme covalently bound to a target RNA moiety. The activatable ribozyme is attached to an immobilizing moiety, which is capable of binding to solid support. Upon activation, the ribozyme cleaves the target RNA moiety thereby producing purified target RNA.

Abstract: An apparatus for sensing liquid flow rate comprises a conduit for conducting a flow of liquid through it and a flow sensor. The flow sensor includes a fixed portion attached to a sidewall of the conduit. The fixed portion has a pair of stationary electrodes positioned in spaced apart relation and adapted to contact the liquid conducted through the conduit. The flow sensor further includes a cartridge portion adapted for removable engagement with the fixed portion. The cartridge portion has sensor terminals adapted to electrically engage the stationary electrodes. In addition, the flow sensor includes an electromagnetic coil operative to generate a magnetic field within the fluid flow.

Abstract: The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.

Abstract: The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.

Abstract: A method of modifying a semiconductor device to provide electrical parameter monitoring. The device includes a semiconductor die and a package substrate. The substrate includes a conductive plane. The die is connected to the plane via a plurality of connection structures. The method includes disconnecting a first one of the connection structures from the plane, and connecting the first connection structure to an external package connection, thereby providing a capability to monitor an electrical parameter of the die via the external package connection.

Abstract: The invention relates to methods of preventing and treating endotoxemia and related disorders. In particular, the invention relates to methods of preventing and treating endotoxemia and related disorders using a probiotic. The invention also relates to methods for assessing the efficacy ot a probiotic in the prevention and treatment of endotoxemia and related disorders.