Abstract: The invention generally relates to inhibitors of DNA double strand break (DSB) repair in cancer cells exposed to DNA-damaging chemotherapy drugs or radiotherapy. In particular, agents that inhibit binding between insulin-like growth factor binding protein-3 (IGFBP-3) and non-POU (pituitary-specific Pit-1, octamer-binding proteins Oct-1 and Oct-2, and neural Unc-86) domain-containing octamer-binding protein (NONO) and methods of using such agents to enhance chemosensitivity or radiosensitivity in cancer treatment are disclosed.

Abstract: A vertical axis wind turbine having a platform and a roof forming a housing for a vertical axis rotor and a stator. Stator vanes extend between the platform and the roof. The stator vanes and guiding surfaces on the platform and the roof define inlets and airflow paths for guiding wind into the inner chamber of the housing, where the wind powers a vertical axis rotor that is rotatably supported on the platform. The stator vanes are segmented with the trailing edges dynamically adjusting the diameter of the inner chamber in response to changing wind and rotor speed conditions. A shaft extending from the rotor can be connected to a generator connected to a power grid. The roof can support a solar panel connected to the power grid.

Abstract: Aspects of the present disclosure are directed toward mitigating water escapement. As may be implemented in accordance with one or more embodiments, an apparatus and/or method involve detecting liquid flow in a liquid channel, and controlling the flow of liquid through the liquid channel with a liquid flow valve in response to control inputs. In response to indicated liquid flow, mitigating the detected liquid flow based upon at least one input variable, each input variable characterizing operational conditions of a premises in which the liquid flow is detected. One or more of control of the flow-arresting circuit and reporting of liquid flow characteristics provided by the flow-arresting circuit are provided via communications with a remote user.

Abstract: Aspects of the present disclosure are directed to tracking authorized individuals, and identifying the presence of unauthorized individuals. As may be consistent with one more embodiments, respective cameras capture images of regions of a common premises, and a filter circuit detects the presence of individuals in the images, and filters the detected presence as follows. The location of one or more authorized users are tracked relative to the premises via location-based information indicative of each authorized user's location. Each detected individual's location is identified and compared to the tracked location of the at least one authorized user. The detected individual is identified as being an unauthorized individual in response to the comparison indicating that the identified location is not common to the tracked location.

Abstract: A vertical axis wind turbine having a platform and a roof forming a housing for a vertical axis rotor and a stator. Stator vanes extend between the platform and the roof. The stator vanes and guiding surfaces on the platform and the roof define inlets and airflow paths for guiding wind into the inner chamber of the housing, where the wind powers a vertical axis rotor that is rotatably supported on the platform. The stator vanes are segmented with the trailing edges dynamically adjusting the diameter of the inner chamber in response to changing wind and rotor speed conditions. A shaft extending from the rotor can be connected to a generator connected to a power grid. The roof can support a solar panel connected to the power grid.

Abstract: Aspects of the present disclosure are directed toward mitigating water escapement. As may be implemented in accordance with one or more embodiments, an apparatus and/or method involve detecting liquid flow in a liquid channel, and controlling the flow of liquid through the liquid channel with a liquid flow valve in response to control inputs. In response to indicated liquid flow, mitigating the detected liquid flow based upon at least one input variable, each input variable characterizing operational conditions of a premises in which the liquid flow is detected. One or more of control of the flow-arresting circuit and reporting of liquid flow characteristics provided by the flow-arresting circuit are provided via communications with a remote user.

Abstract: Aspects of the present disclosure are directed to tracking authorized individuals, and identifying the presence of unauthorized individuals. As may be consistent with one more embodiments, respective cameras capture images of regions of a common premises, and a filter circuit detects the presence of individuals in the images, and filters the detected presence as follows. The location of one or more authorized users are tracked relative to the premises via location-based information indicative of each authorized user's location. Each detected individual's location is identified and compared to the tracked location of the at least one authorized user. The detected individual is identified as being an unauthorized individual in response to the comparison indicating that the identified location is not common to the tracked location.

Abstract: A personal cellular tissue repair, recovery, and regeneration enhancement sleep system for the augmentation of various health promoting metabolic processes associated with sleep via multifunctional stimulus-responsive polymers, performance, and responsive textiles.

Abstract: A personal cellular tissue repair, recovery, and regeneration enhancement sleep system for the augmentation of various health promoting metabolic processes associated with sleep via multifunctional stimulus-responsive polymers, performance, and responsive textiles.

Abstract: The system and methods disclosed herein are directed to valuing, comparing, and projecting mortgage loan portfolios based on residential real estate. The disclosed system enables portfolio managers to efficiently and accurately evaluate mortgage loan portfolios based on residential real estate. In one embodiment, a user can run detailed scenarios and then review comprehensive results of scenario runs using interactive tabs. The user can modify scenarios, assumptions, and individual parameters on the fly. The system provides aggregated information about a selected portfolio, as well as loan level information, from the same application.

Abstract: A web-enabled automation control module (ACM) system includes at least one network module configured to receive a request for a file from the network, a web server and database module located outside the network module and including a database configured to store the file, and an ACM central processing unit (CPU) configured to send ACM data to the web server and database module to embed ACM data in the file.

Abstract: Automated web-based systems and methods for matching healthcare professionals with healthcare organizations on a temporary basis are disclosed. The systems and methods of the present invention utilize a secure online portal to facilitate communication between healthcare organizations and locum tenens recruitment agencies. The present invention automates and manages all aspects of the connecting of healthcare organizations and vendors for the purpose of matching and placing of temporary medical professionals with healthcare organizations.

Abstract: A variable acuity imager incorporates an array of detection elements for light energy, in the visible, infrared, ultraviolet, or light energy in another region of the electromagnetic spectrum with a means to change the spatial configuration of the array to include “superpixels” by combining energy detected by adjacent elements, thus permitting any number of high-resolution “foveal” regions to be placed within the confines of the focal plane array and moved around at the frame rate of the imaging device. Detectors to measure the pitch, yaw and roll angle rates of background imagery using velocity-sensing circuitry are employed for variation of the foveal regions to accommodate motion of the array.

Abstract: The present invention relates to an improved method for cleaning using plasma In particular, the present invention relates to the plasma cleaning and decontamination of instruments for use in medicine, dentistry and food preparation whereby the soiled item is exposed to a solvent and then to a plasma, whereby this enables excitation of water within the soil itself.

Abstract: An automation control module (ACM) includes an ACM central processing unit (CPU), a backplane electrically coupled to the ACM CPU, and a web system embedded within the ACM and electrically coupled to the ACM CPU and backplane. The web system includes a secure web server and is configured to process hypertext transfer protocol (HTTP) requests from a network to program and configure the ACM through the network. The HTTP requests are received by the secure web server and transmitted by the secure web server directly the ACM CPU without using the backplane.

Abstract: An automation control module (ACM) is provided that includes an ACM central processing unit (CPU), a backplane and a SOAP/XML and web server system electrically coupled to the backplane and to the ACM CPU. The SOAP/XML and web server system is embedded within the automation control module (ACM) and is configured to process simple object access protocol (SOAP)/extensible markup language (XML) requests from a network.

Abstract: A method and apparatus for reducing the number of DQ pins and current used to access data in a memory system or data transfer device, wherein an additional bit is temporally encoded on a data word during a singular access cycle. During an access cycle, the pulse level or levels of encoded bits may determine one or more bits values in a data word being expressed, while the pulse/pulses position in time within a data access cycle determines the remaining bits.

Abstract: A variable acuity imager incorporates an array of detection elements for light energy, in the visible, infrared, ultraviolet, or light energy in another region of the electromagnetic spectrum with a means to change the spatial configuration of the array to include “superpixels” by combining energy detected by adjacent elements, thus permitting any number of high-resolution “foveal” regions to be placed within the confines of the focal plane array and moved around at the frame rate of the imaging device. Detectors to measure the pitch, yaw and roll angle rates of background imagery using velocity-sensing circuitry are employed for variation of the foveal regions to accommodate motion of the array.

Abstract: A variable acuity imager incorporates an array of detection elements for light energy, in the visible, infrared, ultraviolet, or light energy in another region of the electromagnetic spectrum with a means to change the spatial configuration of the array to include “superpixels” by combining energy detected by adjacent elements, thus permitting any number of high-resolution “foveal” regions to be placed within the confines of the focal plane array and moved around at the frame rate of the imaging device. Detectors to measure the pitch, yaw and roll angle rates of background imagery using velocity-sensing circuitry are employed for variation of the foveal regions to accommodate motion of the array.

Abstract: A system and method for creating a ring tone for an electronic device takes as input a phrase sung in a human voice and transforms it into a control signal controlling, for example, a ringer on a cellular telephone. Time-varying features of the input signal are analyzed to segment the signal into a set of discrete notes and assigning to each note a chromatic pitch value. The set of note start and stop times and pitches are then translated into a format suitable for controlling the device.