Abstract: The invention generally relates to inhibitors of DNA double strand break (DSB) repair in cancer cells exposed to DNA-damaging chemotherapy drugs or radiotherapy. In particular, agents that inhibit binding between insulin-like growth factor binding protein-3 (IGFBP-3) and non-POU (pituitary-specific Pit-1, octamer-binding proteins Oct-1 and Oct-2, and neural Unc-86) domain-containing octamer-binding protein (NONO) and methods of using such agents to enhance chemosensitivity or radiosensitivity in cancer treatment are disclosed.

Abstract: Aspects of the present disclosure are directed toward mitigating water escapement. As may be implemented in accordance with one or more embodiments, an apparatus and/or method involve detecting liquid flow in a liquid channel, and controlling the flow of liquid through the liquid channel with a liquid flow valve in response to control inputs. In response to indicated liquid flow, mitigating the detected liquid flow based upon at least one input variable, each input variable characterizing operational conditions of a premises in which the liquid flow is detected. One or more of control of the flow-arresting circuit and reporting of liquid flow characteristics provided by the flow-arresting circuit are provided via communications with a remote user.

Abstract: Aspects of the present disclosure are directed to tracking authorized individuals, and identifying the presence of unauthorized individuals. As may be consistent with one more embodiments, respective cameras capture images of regions of a common premises, and a filter circuit detects the presence of individuals in the images, and filters the detected presence as follows. The location of one or more authorized users are tracked relative to the premises via location-based information indicative of each authorized user's location. Each detected individual's location is identified and compared to the tracked location of the at least one authorized user. The detected individual is identified as being an unauthorized individual in response to the comparison indicating that the identified location is not common to the tracked location.

Abstract: Aspects of the present disclosure are directed toward mitigating water escapement. As may be implemented in accordance with one or more embodiments, an apparatus and/or method involve detecting liquid flow in a liquid channel, and controlling the flow of liquid through the liquid channel with a liquid flow valve in response to control inputs. In response to indicated liquid flow, mitigating the detected liquid flow based upon at least one input variable, each input variable characterizing operational conditions of a premises in which the liquid flow is detected. One or more of control of the flow-arresting circuit and reporting of liquid flow characteristics provided by the flow-arresting circuit are provided via communications with a remote user.

Abstract: Aspects of the present disclosure are directed to tracking authorized individuals, and identifying the presence of unauthorized individuals. As may be consistent with one more embodiments, respective cameras capture images of regions of a common premises, and a filter circuit detects the presence of individuals in the images, and filters the detected presence as follows. The location of one or more authorized users are tracked relative to the premises via location-based information indicative of each authorized user's location. Each detected individual's location is identified and compared to the tracked location of the at least one authorized user. The detected individual is identified as being an unauthorized individual in response to the comparison indicating that the identified location is not common to the tracked location.

Abstract: The present invention relates to an improved method for cleaning using plasma In particular, the present invention relates to the plasma cleaning and decontamination of instruments for use in medicine, dentistry and food preparation whereby the soiled item is exposed to a solvent and then to a plasma, whereby this enables excitation of water within the soil itself.

Abstract: A method and apparatus for reducing the number of DQ pins and current used to access data in a memory system or data transfer device, wherein an additional bit is temporally encoded on a data word during a singular access cycle. During an access cycle, the pulse level or levels of encoded bits may determine one or more bits values in a data word being expressed, while the pulse/pulses position in time within a data access cycle determines the remaining bits.

Abstract: A system and method for creating a ring tone for an electronic device takes as input a phrase sung in a human voice and transforms it into a control signal controlling, for example, a ringer on a cellular telephone. Time-varying features of the input signal are analyzed to segment the signal into a set of discrete notes and assigning to each note a chromatic pitch value. The set of note start and stop times and pitches are then translated into a format suitable for controlling the device.

Abstract: A method for configuring content to be provided to a client comprises receiving information specifying characteristics of the client; modifying reference content that represents content to be provided to the client according to multiple modification processes to generate multiple versions of the reference content, each modification process applying different modifications related to the characteristics of the client; for each version, determining respective values associated with multiple attributes of the version; for each of the values for the different versions that are associated with the same attribute, normalizing the value to be comparable with values associated with the other attributes; for each version, generating a combination of the normalized values associated with the multiple attributes of the version; and selecting one of the modification processes based on a value of the combination of the normalized values.

Abstract: A method for configuring a communication system is described. The method includes, for each of a plurality of requests in a communication protocol between a client and a server, estimating values for a plurality of attributes associated with the request, and computing a resource usage estimate, based on a plurality of the estimated attributes, that represents resources used by the communication protocol in response to the request. The method also includes determining at least one group of two or more requests to combine into a combined request based on the respective resource usage estimates for the requests to be combined, and storing a program module for executing the communication protocol including instructions for processing the combined requests.

Abstract: A method for configuring an application comprises receiving information that specifies a set of multiple states with which the application is associated during execution; receiving information that specifies whether each of one or more program modules is active during respective states, at least some of the program modules having multiple instantiations configured to execute with different performance characteristics; receiving information that specifies performance characteristics associated with the multiple instantiations for each of at least some program modules that have multiple instantiations; and selecting one of the instantiations for each program module that has multiple instantiations based on at least one performance criterion associated with the application that depends on whether the program modules are active in respective states.

Abstract: A method for configuring a communication protocol between a client and a server is described. The method comprises, for each of a plurality of potential requests from the client to the server, estimating values for a plurality of attributes associated with the request, and computing a resource usage estimate, based on a plurality of the estimated attributes, that represents resources used by at least one of the client and the server in response to the request. The method also comprises determining at least one group of two or more requests to combine into a combined request based on the respective resource usage estimates for the requests to be combined, and determining whether to combine another group of requests based at least in part on a performance measure that characterizes performance of the configured communication protocol.

Abstract: A method for configuring a system that includes a server in communication with a client according to a communication protocol is described. The method comprises determining at least two of an application metric that characterizes performance of multiple possible instantiations of an application, each instantiation being configured to execute on the client with different performance characteristics, a protocol metric that characterizes performance of multiple possible groupings of requests such that requests in the same group are processed according to a combined request of the communication protocol, and a content metric that characterizes performance of multiple possible modification processes for modifying content to be provided to the client.

Abstract: A channel for managing equipment cables that includes opposing first and second members and a third member extending between and connecting the first and second members. Each of the first and second members includes first and second inner and outer surfaces. At least one cable receiving area is defined between the first and second inner surfaces of the first and second members. First and second equipment mounting elements extend from each of the first and second outer surfaces of the first and second members. The first and second equipment mounting elements are connectable to equipment. A base support is coupled to at least one of the first and second members.

Abstract: An approach for delivering encoded content data to a portable device is described. The content data is encoded to form encoded content data. The instruction data is combined with the encoded content data to generate a data stream that is able to be recognized by a target operating environment as executable. The data stream is delivered to a portable device capable of running the target operating environment. A program, included in the instruction data, is executed in the target operating environment on the portable device to initiate decoding of the encoded content data based decoding instructions included in the instruction data. The decoded content data is presented on the portable device.

Abstract: The acid-labile sub-unit (ALS) of insulin like growth factor binding protein complex in biologically pure form is described. ALS has a molecular weight between 80-115 kd as determined by SDS polyacrylamide gel electrophoresis, run under reducing conditions; and a partial N-terminal amino acid sequence as follows: Gly(Ala)AspProGlyThrProGlyGluAlaGlu (SEQ ID NO:1) GlyProAlaCysProAlaAlaCys wherein the first amino acid may be Gly or Ala. Also described are methods of producing ALS, compositions containing the in-vivo IGF protein complex, methods of detecting ALS in body fluids, recombinant nucleic acid sequences encoding ALS, and expression vectors and host cells containing such nucleic acid sequences.

Abstract: A hinged swing bracket assembly for a telecommunications rack system has first, second and third arms. The first arm has a first end and a second end and is adapted to be connected to a support. The second arm has first and second ends. The first end of the second arm is pivotally connected to the first arm and the second end of the second arm is releasably connected to the first end of the first arm. The third arm has first and second ends. The first end of the third arm is pivotally connected to the second end of the second arm, and the second end of the third arm is releasably connected to the first end of the second arm.

Abstract: A compensating advanced feature patch panel that can include removable modular or fixed electronic components located directly on the patch panel which are separately or in combination capable of providing advanced features such as device detection and power insertion. The patch panel provides communications between an insulation displacement connector (IDC) at a PD/User end, and any standard interface type using unshielded twisted pair cables, such as an RJ45 connector at a switch end at performance levels of at least category 3, 5, 6e, 6 and/or higher (e.g. 6e or 7) and equivalent performance levels by compensating for the active electronics used in providing advanced features. Compensation is achieved in part through the separation and isolation of active and communication circuit elements.

Abstract: A system and method for creating a ring tone for an electronic device takes as input a phrase sung in a human voice and transforms it into a control signal controlling, for example, a ringer on a cellular telephone. Time-varying features of the input signal are analyzed to segment the signal into a set of discrete notes and assigning to each note a chromatic pitch value. The set of note start and stop times and pitches are then translated into a format suitable for controlling the device.

Abstract: A system and method for creating a ring tone for an electronic device takes as input a phrase sung in a human voice and transforms it into a control signal controlling, for example, a ringer on a cellular telephone. Time-varying features of the input signal are analyzed to segment the signal into a set of discrete notes and assigning to each note a chromatic pitch value. The set of note start and stop times and pitches are then translated into a format suitable for controlling the device.