Abstract: A system and corresponding method for post-treatment patient compliance for a medical patient is performed by a system having a memory operable to retain a series of instructions, and a processor operable to retrieve and execute the instructions to perform a series of steps. One step includes receiving as a first input any one of: information from a patient management system regarding the patient; information from a patient interview conducted with the patient; and information from one or more manual inputs. A patient treatment plan is generated based on the first input. As a second input, any one of: a drug interaction based information; an evidence-based clinical decision information; and a custom clinical input information, are received. Also, a third input of a treatment recommendation process is received. A comparison based on any two of the above first, second and third inputs is performed. A post-treatment recommendation specific to the patient is determined for the patient based on the comparison.