Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel are repeated at least twice and followed by a short-and-instant telemetry messaging (SIM) transmission on a third RF channel is operable to exchange data between a network and beacons using a wireless communications channel that permits the beacons to access the network for identification of the beacons.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel are repeated at least twice and followed by a location tacking messaging (LOC) transmission on a third RF channel is operable to identify location between a network and beacons using a wireless communications channel that permits the beacons to be tracked by the network for location of the beacons.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel and a location tacking messaging (LOC) transmission on a third RF channel is operable to identify location between a network and beacons using a wireless communications channel that permits the beacons to be tracked by the network for location of the beacons.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel and a short-and-instant telemetry messaging (SIM) transmission on a third RF channel is operable to exchange data between a network and beacons using a wireless communications channel that permits the beacons to access the network for identification of the beacons.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel and a short-and-instant telemetry messaging (SIM) transmission on a third RF channel is operable to exchange data between a network and beacons using a wireless communications channel that permits the beacons to access the network for identification of the beacons.

Abstract: Systems, methods and apparatus are provided through which in some implementations a here-i-am (HIA) transmission on a first RF channel, a registration (REG) transmission on a second RF channel and a location tacking messaging (LOC) transmission on a third RF channel is operable to identify location between a network and beacons using a wireless communications channel that permits the beacons to be tracked by the network for location of the beacons.

Abstract: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signalling molecule comprising a peptide or functional analogue thereof. Furthermore, the invention provides a method for identifying or obtaining a signalling molecule comprising a peptide or functional derivative or analogue thereof capable of modulating expression of a gene in a cell comprising providing the cell with a peptide or derivative or analogue thereof and determining the activity and/or nuclear translocation of a gene transcription factor.

Abstract: The description relates to the treatment of the inflammatory component of neurological disorders or so called neuroimmune disorders such as schizophrenia, manic depression and other bipolar disorders, multiple sclerosis, post-partum psychosis and autism, herein also called inflammatory neurological disorders. Provided are methods for modulating a neurological disorder in a subject comprising providing the subject with a gene-regulatory peptide or functional analogue thereof. Also provided is use of an NF-kappaB down-regulating peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of a neurological disorder.

Abstract: Described are methods and associated means for treating a subject, such as a mammal, experiencing or thought to be at risk for hemorrhagic shock. Such methods include administering to the subject in a medically acceptable manner, a short oligopeptide such as AQGV (SEQ ID NO:1) and/or LQGV (SEQ ID NO:2).

Abstract: Provided is the use of a gene-regulatory peptide or functional analogue thereof for the treatment of a disease comprising an inflammatory condition and/or a counter-inflammatory condition wherein a subject suffering from the disease is subjected to a diagnostic process aimed at determining inflammatory disease stage of the subject and where treatment is selected depending on the outcome of the determination of disease stage.

Abstract: Described are treatments of disease wherein a gene-regulatory peptide as provided herein is useful as a modulator of NF-kappaB. Also described is a pharmaceutical composition for topical application comprising a gene-regulatory peptide or functional analogue thereof, wherein the peptide or analogue modulates translocation and/or activity of a gene transcription factor.

Abstract: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signalling molecule comprising a peptide or functional analogue thereof. Furthermore, the invention provides a method for identifying or obtaining a signalling molecule comprising a peptide or functional derivative or analogue thereof capable of modulating expression of a gene in a cell comprising providing the cell with a peptide or derivative or analogue thereof and determining the activity and/or nuclear translocation of a gene transcription factor.

Abstract: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of anthrax. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signaling molecule comprising a peptide or functional analogue thereof.

Abstract: A civil aviation passive coherent location system and method is disclosed. A receiver subsystem receives reference transmissions from an uncontrolled transmitter. The receiver subsystem also receives scattered transmissions originating from the uncontrolled transmitter and scattered by an airborne object. The received transmissions are compared to determine measurement differentials, such a frequency-difference-of-arrival, a time-difference-of-arrival and an angle of arrival. From the measurement differentials, an object state estimate is determined. A previous state estimate may be updated with the determined state estimate. Processing subsystems determine the measurement differentials and state estimates.

Abstract: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of anthrax. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signaling molecule comprising a peptide or functional analogue thereof.

Abstract: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing said cell with a signalling molecule comprising a peptide or functional analogue thereof. Furthermore, the invention provides a method for identifying or obtaining a signalling molecule comprising a peptide or functional derivative or analogue thereof capable of modulating expression of a gene in a cell comprising providing said cell with a peptide or derivative or analogue thereof and determining the activity and/or nuclear translocation of a gene transcription factor.

Abstract: A system and method for enhancing object state awareness is disclosed. The system includes a receiver subsystem that receives reference signals from an uncontrolled transmitter and scattered transmissions originating from the uncontrolled transmitter and scattered by an object. The system also includes a front-end processing subsystem that determines a radial velocity of the object based on the received transmissions. The system also includes a back-end processing subsystem that determines object state estimates based on the determined radial velocity.

Abstract: A civil aviation passive coherent location system and method is disclosed. A receiver subsystem receives reference transmissions from an uncontrolled transmitter. The receiver subsystem also receives scattered transmissions originating from the uncontrolled transmitter and scattered by an airborne object. The received transmissions are compared to determine measurement differentials, such a frequency-difference-of-arrival, a time-difference-of-arrival and an angle of arrival. From the measurement differentials, an object state estimate is determined. A previous state estimate may be updated with the determined state estimate. Processing subsystems determine the measurement differentials and state estimates.

Abstract: A system and method for enhancing object state awareness is disclosed. The system includes a receiver subsystem that receives reference signals from an uncontrolled transmitter and scattered transmissions originating from the uncontrolled transmitter and scattered by an object. The system also includes a front-end processing subsystem that determines a radial velocity of the object based on the received transmissions. The system also includes a back-end processing subsystem that determines object state estimates based on the determined radial velocity.