Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin level.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels. In some embodiments, the compounds disclosed herein are formulated for delivery via inhalation. In some embodiments, the compounds disclosed herein are useful for the treatment of respiratory disorders.

Abstract: A system and associated functionality are described for identifying, verifying, and replacing insertion opportunity information in content streams. A trigger replacement system (100) for use in an addressable advertising context includes a watermark detector (102) receives a video stream and detects triggers that indicate an insertion opportunity such as watermarks. Information from the watermarks is provided to a logic and decision server (104) that also receives a metadata feed relating to addressable insertion opportunities, assets, and targeting parameters. Once the logic and decision server (104) has processed the watermark information and the metadata feed, the server (104) generates replacement cue information identifying the addressable insertion opportunity.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: A method and apparatus are disclosed for preparing program data for delivery to internet-enabled client devices implementing a targeted advertising scheme. A data combining apparatus (100) and associated data are provided for generating a combined manifest file. The apparatus (100) includes a demultiplexer (104), a data message handler (102), an A/V segmenter (103), and a manifest and metadata combiner (104). A content stream (105) (e.g., MPEG-TS) may be received at demultiplexer (104) and separated into data messages (i.e., metadata) and A/V content. Data message handler (102) may process the data messages into data message files (106) which include metadata. A/V segmenter (103) may segment the A/V content into A/V file chunks and generate manifest files (107) which include PTSs. Manifest and metadata combiner (104) may merge the data message files (106) and manifest files (107) into combined manifest files (108).

Abstract: The present invention is directed to inhibitors of cathepsins and the methods for using and making such inhibitors.

Abstract: The present invention is directed to inhibitors of cathepsins and the methods for using and making such inhibitors.

Abstract: Apparatus for use in measuring properties of media formed from a particulate suspension. The apparatus includes a media sampler coupled to feed pipes to allow media to flowing therethrough to be sampled and a connector for coupling the media sampler to a sensor for sensing properties of the sampled media.

Abstract: The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.

Abstract: The present invention concerns methods of using Cathepsin S inhibitors and compounds of Formula I that are inhibitors of cathepsin S in treating CNS disorders, diseases, and injuries, particularly neurodegenerative conditions. The present invention is directed to pharmaceutical compositions comprising these compounds for treating CNS disorders.

Abstract: A support device is provided for supporting one or more objects above a ground surface. The device includes a QO body portion and location means associated with the body portion to allow location and/or engagement of one or more objects with the device in use. The body portion has at least one compartment defined therein for containing strengthening means.

Abstract: The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.

Abstract: A method of mounting an antenna assembly into computer apparatus including forming a mounting bracket on an interior surface of a housing of the computer apparatus, the mounting bracket including at least two upstanding surfaces defining a gap therebetween, and inserting a first portion of the antenna assembly into engagement with the mounting bracket and adhering a second portion of the antenna assembly to the interior surface.

Abstract: Apparatus for use in measuring properties of media formed from a particulate suspension. The apparatus includes a media sampler coupled to feed pipes to allow media to flowing therethrough to be sampled and a connector for coupling the media sampler to a sensor for sensing properties of the sampled media.

Abstract: A support device is provided for supporting one or more objects above a ground surface. The device includes a body portion and location means associated with the body portion to allow location and/or engagement of one or more objects with the device in use. The body portion has at least one compartment defined therein for containing strengthening means.

Abstract: A method of mounting an antenna assembly into computer apparatus including forming a mounting bracket on an interior surface of a housing of the computer apparatus, the mounting bracket including at least two upstanding surfaces defining a gap therebetween, and inserting a first portion of the antenna assembly into engagement with the mounting bracket and adhering a second portion of the antenna assembly to the interior surface.

Abstract: A set of distal femoral knee prostheses which are designed to be more narrow in medial/lateral dimensions with increasing anterior/posterior size than existing prostheses to more closely correspond to the physical anatomy of female patients. The prostheses are designed to have a substantially trapezoidal shape or profile when viewed distally which features a more pronounced narrowing of the medial/lateral dimensions beginning at the posterior end of the prostheses and progressing anteriorly to the anterior end of the prostheses. Additionally, the prostheses each include a reduced profile patellar sulcus and reduced profile anterior condyles to more closely conform to the anatomy of a resected femur, and also include sulcus tracking optimized to conform to female anatomy.