Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels. In some embodiments, the compounds disclosed herein are formulated for delivery via inhalation. In some embodiments, the compounds disclosed herein are useful for the treatment of respiratory disorders.

Abstract: A system and associated functionality are described for identifying, verifying, and replacing insertion opportunity information in content streams. A trigger replacement system (100) for use in an addressable advertising context includes a watermark detector (102) receives a video stream and detects triggers that indicate an insertion opportunity such as watermarks. Information from the watermarks is provided to a logic and decision server (104) that also receives a metadata feed relating to addressable insertion opportunities, assets, and targeting parameters. Once the logic and decision server (104) has processed the watermark information and the metadata feed, the server (104) generates replacement cue information identifying the addressable insertion opportunity.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Abstract: A method and apparatus are disclosed for preparing program data for delivery to internet-enabled client devices implementing a targeted advertising scheme. A data combining apparatus (100) and associated data are provided for generating a combined manifest file. The apparatus (100) includes a demultiplexer (104), a data message handler (102), an A/V segmenter (103), and a manifest and metadata combiner (104). A content stream (105) (e.g., MPEG-TS) may be received at demultiplexer (104) and separated into data messages (i.e., metadata) and A/V content. Data message handler (102) may process the data messages into data message files (106) which include metadata. A/V segmenter (103) may segment the A/V content into A/V file chunks and generate manifest files (107) which include PTSs. Manifest and metadata combiner (104) may merge the data message files (106) and manifest files (107) into combined manifest files (108).

Abstract: A magnetic mounting system configured to mount various items onto a surface or structure while allowing for ease of customization of the mounted item without damaging the surface or structure. The magnetic mounting system comprising a plate including a front surface and a back surface, at least one plate mount, and at least one display mount. The plate is received by the at least one plate mount at the back surface of the plate and the at least one display mount is received by the plate at the front surface. The at least one display mount is configured to receive an item, such that the item can be mounted to the front surface of the plate. The at least one plate mount is configured to be coupled to a wall or surface, such that the plate can be removably mounted to the wall or surface.

Abstract: The present invention is directed to inhibitors of cathepsins and the methods for using and making such inhibitors.

Abstract: The present invention is directed to inhibitors of cathepsins and the methods for using and making such inhibitors.

Abstract: A fault detection system for an over-speed protection system of a rotating machine includes a first speed sensor, second speed sensor, and third speed sensor sensing a speed of a shaft of the rotating machine. The system includes a first input configured to receive a first pulse train from the first speed sensor, a second input configured to receive a second pulse train from the second speed sensor, a third input configured to receive a third pulse train from the third speed sensor, and a processor configured to generate a shutdown signal for the rotating machine based on the first pulse train, the second pulse train, and the third pulse train.

Abstract: Apparatus for use in measuring properties of media formed from a particulate suspension. The apparatus includes a media sampler coupled to feed pipes to allow media to flowing therethrough to be sampled and a connector for coupling the media sampler to a sensor for sensing properties of the sampled media.

Abstract: A fault detection system for an over-speed protection system of a rotating machine includes a first speed sensor, second speed sensor, and third speed sensor sensing a speed of a shaft of the rotating machine. The system includes a first input configured to receive a first pulse train from the first speed sensor, a second input configured to receive a second pulse train from the second speed sensor, a third input configured to receive a third pulse train from the third speed sensor, and a processor configured to generate a shutdown signal for the rotating machine based on the first pulse train, the second pulse train, and the third pulse train.

Abstract: The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.

Abstract: A system for providing power to a device includes a first power supply unit having a first power module that provides A.C. power and is selectively connectable to input lines and a first communication module. The system also includes a second power supply unit having a second power module selectively connectable to the input lines and that provides A.C. power and a second communication module coupled to the first communication module. Only one of the first or second power supply units is coupled to the input lines at a given time.

Abstract: Embodiments provide systems and methods for controlling electronic circuitry. A system can include at least a first controller and a second controller and at least one power electronic circuitry module. The first controller can be in electrical communication with the power electronic circuitry module via a first high-speed serial link (HSSL). The second controller can be in electrical communication with the power electronic circuitry module via a second HSSL.

Abstract: The present invention concerns methods of using Cathepsin S inhibitors and compounds of Formula I that are inhibitors of cathepsin S in treating CNS disorders, diseases, and injuries, particularly neurodegenerative conditions. The present invention is directed to pharmaceutical compositions comprising these compounds for treating CNS disorders.

Abstract: A support device is provided for supporting one or more objects above a ground surface. The device includes a QO body portion and location means associated with the body portion to allow location and/or engagement of one or more objects with the device in use. The body portion has at least one compartment defined therein for containing strengthening means.

Abstract: The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.

Abstract: A system for providing redundant power to a device includes a first power supply unit that includes a first communication module including first and second first power supply unit transmitters and first and second first power supply unit receivers and a second power supply unit that includes a second communication module coupled to the first communication module and including first and second second power supply unit transmitters and first and second second power supply unit receivers coupled, respectively, to the first and second first power supply unit transmitters. The first power supply unit transmits on both the first and second first transmitters and the second power supply is configured to provide power to the device in the event that signals are not received from both the first and second first power supply unit transmitters by the first and second second power supply unit receivers.

Abstract: A system for providing redundant power to a device includes a first power supply unit that includes a first communication module including first and second first power supply unit transmitters and first and second first power supply unit receivers and a second power supply unit that includes a second communication module coupled to the first communication module and including first and second second power supply unit transmitters and first and second second power supply unit receivers coupled, respectively, to the first and second first power supply unit transmitters. The first power supply unit transmits on both the first and second first transmitters and the second power supply is configured to provide power to the device in the event that signals are not received from both the first and second first power supply unit transmitters by the first and second second power supply unit receivers.