Patents by Inventor Robert Bradbury

Robert Bradbury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS RELATING TO CHARACTERIZATION AND THERAPEUTIC APPLICATION OF PRISTINE STEM CELLS
    Publication number: 20090305905
    Abstract: “Pristine” stem cells are provided by a process of precise selection wherein stem cells exhibiting ideal behavior, good morphology and proper gene expression are selected. Stem cells are divided into pools and observed for optimum speed of growth, proper gene expression levels, and other tests indicative of healthy cell function due to lack of mutation or misrepair of genes. Autologous pools of such “pristine” stem cells provide a source of stem cells having the genome least affected by mutation, and therefore in a more pristine state.
    Type: Application
    Filed: December 12, 2008
    Publication date: December 10, 2009
    Inventor: Robert Bradbury
  • Quinazoline Derivatives
    Publication number: 20070244136
    Abstract: A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.
    Type: Application
    Filed: November 11, 2004
    Publication date: October 18, 2007
    Inventors: Laurent Hennequin, Robert Bradbury, Jason Kettle
  • Quinazoline Derivatives as Erbb Receptor Tyrosine kinases
    Publication number: 20070232607
    Abstract: The invention concerns quinazoline derivatives of the formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, X1, Q1, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
    Type: Application
    Filed: June 2, 2005
    Publication date: October 4, 2007
    Inventors: Robert Bradbury, Jason Kettle, James Scott, Bernard Barlaam
  • 4-Anilino-quinazoline derivatives as antiproliferative agents
    Publication number: 20070149546
    Abstract: A quinazsoline derivative of the formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrxosine kinase in a warm blooded animnal such as man.
    Type: Application
    Filed: April 20, 2004
    Publication date: June 28, 2007
    Inventors: Robert Bradbury, Jason Kettle
  • Quinazoline derivatives
    Publication number: 20070099943
    Abstract: The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
    Type: Application
    Filed: December 11, 2006
    Publication date: May 3, 2007
    Inventors: Robert Bradbury, Jason Kettle, James McCabe, Andrew Turner, Laurent Hennequin
  • Quinazoline derivatives as antitumor agents
    Publication number: 20070088044
    Abstract: The invention concerns quinazoline derivatives of Formula (I); wherein each of Q<1>, Q<2>, Z, R<1>, R<2>, R<3>, and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
    Type: Application
    Filed: May 31, 2006
    Publication date: April 19, 2007
    Inventors: Laurent Hennequin, Jason Kettle, Martin Pass, Robert Bradbury
  • Quinazoline derivatives as antitumor agents
    Publication number: 20070082921
    Abstract: The invention concerns quinazoline derivatives of Formula (I); wherein each of Q<1>, Q<2>, Z, R<1>, R<2>, R<3>, and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
    Type: Application
    Filed: May 31, 2006
    Publication date: April 12, 2007
    Inventors: Laurent Hennequin, Jason Kettle, Martin Pass, Robert Bradbury
  • Quinazoline derivatives
    Publication number: 20070043010
    Abstract: The invention concerns a quinazoline derivative of the Formula (I): wherein each of the variables have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
    Type: Application
    Filed: September 22, 2004
    Publication date: February 22, 2007
    Applicant: ASTRAZENECA UK LIMITED
    Inventors: Robert Bradbury, Christopher Halsall, Jason Kettle, Alleyn Plowright, Laurent Hennequin
  • Quinazoline derivatives
    Publication number: 20070037837
    Abstract: The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, R2, X1, R5 and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.
    Type: Application
    Filed: September 15, 2004
    Publication date: February 15, 2007
    Inventors: Laurent Francois Hennequin, Bernard Barlaam, Robert Bradbury
  • Quinazoline derivatives as tyrosine kinase inhibitors
    Publication number: 20070032508
    Abstract: A quinazoline derivative of the formula (I); wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
    Type: Application
    Filed: September 14, 2004
    Publication date: February 8, 2007
    Inventors: Robert Bradbury, Jason Kettle, Laurent Hennequin, Bernard Barlaam
  • Quinazoline derivatives as antitumor agents
    Publication number: 20070015743
    Abstract: A quinazoline derivative of the formula (I): (A chemical formula should be inserted here—please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
    Type: Application
    Filed: September 14, 2004
    Publication date: January 18, 2007
    Inventors: Robert Bradbury, Jason Kettle, Laurent Hennequin
  • 4-anilino quinazoline derivatives as antiproliferative agents
    Publication number: 20050215574
    Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
    Type: Application
    Filed: March 26, 2003
    Publication date: September 29, 2005
    Inventors: Robert Bradbury, Laurent Francois Hennequin, Jason Kettle
  • Quinazoline derivatives
    Publication number: 20050165035
    Abstract: The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
    Type: Application
    Filed: June 1, 2004
    Publication date: July 28, 2005
    Inventors: Robert Bradbury, Jason Kettle, James McCabe, Andrew Turner, Laurent Hennequin
  • 2,4,DI (hetero-) arylamino (-oxy) -5-substituted pyrimidines as antineoplastic agents
    Publication number: 20050090515
    Abstract: Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.
    Type: Application
    Filed: November 24, 2004
    Publication date: April 28, 2005
    Inventors: Elizabeth Pease, Emma Williams, Robert Bradbury, Stuart Pearson
  • Quinazoline derivatives as antitumor agents
    Publication number: 20050054662
    Abstract: The invention concerns quinazoline derivatives of Formula (I); wherein each of Q1, Q2, Z, R1, R2, R3, and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
    Type: Application
    Filed: October 31, 2002
    Publication date: March 10, 2005
    Inventors: Laurent Hennequin, Jason Kettle, Martin Pass, Robert Bradbury
  • Quinazoline derivatives as antitumor agents
    Publication number: 20050043336
    Abstract: The invention concerns quinazoline derivatives of Formula (I); wherein each of Q1, Q2, Z, R1, R2, R3, and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
    Type: Application
    Filed: October 31, 2002
    Publication date: February 24, 2005
    Inventors: Laurent Hennequin, Jason Kettle, Martin Pass, Robert Bradbury