Patents by Inventor Robert Brazas

Robert Brazas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional Mutations In Respiratory Syncytial Virus
    Publication number: 20130266600
    Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
    Type: Application
    Filed: January 16, 2013
    Publication date: October 10, 2013
    Inventors: Hong Jin, Robert Brazas, Bin Lu
  • FUNCTIONAL MUTATION IN RESPIRATORY SYNCYTIAL VIRUS
    Publication number: 20120282673
    Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
    Type: Application
    Filed: May 17, 2012
    Publication date: November 8, 2012
    Applicant: Medlmmune, LLC
    Inventors: Hong JIN, Robert Brazas, Bin Lu
  • Functional Mutations In Respiratory Syncytial Virus
    Publication number: 20100190232
    Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
    Type: Application
    Filed: August 7, 2009
    Publication date: July 29, 2010
    Applicant: MEDIMMUNE, LLC
    Inventors: Hong Jin, Robert Brazas, Bin Lu
  • Functional Mutations In Respiratory Syncytial Virus
    Publication number: 20090117150
    Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
    Type: Application
    Filed: September 30, 2008
    Publication date: May 7, 2009
    Applicant: MEDIMMUNE, LLC
    Inventors: Hong Jin, Robert Brazas, Bin Lu