Patents by Inventor Robert Bremel

Robert Bremel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060160220
    Abstract: The present invention relates to improved retroviral vectors. In particular, the present invention relates to retroviral vectors that retain introns in genes of interest during vector production. The present invention further provides host cells and animals comprising gene delivered by the vectors. The present invention additionally provides methods of using such retroviral vectors, host cells and animals in research, diagnostic and therapeutic applications.
    Type: Application
    Filed: November 14, 2005
    Publication date: July 20, 2006
    Applicant: ioGenetics
    Inventors: Robert Bremel, Jerome Harms
  • Publication number: 20050100952
    Abstract: The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vectors, lentivirus vectors, transposon vectors, and adeno-associated virus vectors. Methods are provided in which the host cells are prepared by using the integrating vectors at a high multiplicity of infection. The host cells are useful for producing pharmaceutical proteins, variants of proteins for use in screening assays, and for direct use in high throughput screening.
    Type: Application
    Filed: December 21, 2004
    Publication date: May 12, 2005
    Inventors: Robert Bremel, Linda Miller, Gregory Bleck
  • Publication number: 20050026288
    Abstract: Inducible gene expression systems and a method thereof. A first inducible gene expression system includes a first vector comprising at least one retroviral promoter and at least one factor to induce the retroviral promoter. At least one gene product is expressed in proportion to retroviral promoter induction. The method includes providing a first vector comprising at least one retroviral promoter and providing at least one factor corresponding to the retroviral promoter. The retroviral promoter is induced with the at least one factor. At least one protein is expressed based on the induction of the retroviral promoter. A second inducing expression system includes first vector means comprising at least one retroviral promoter, means for inducing the retroviral promoter, and means for expressing at least one protein based on the induction of the retroviral promoter.
    Type: Application
    Filed: January 23, 2004
    Publication date: February 3, 2005
    Inventors: Jerome Harms, Gary Splitter, Kurt Eakle, Robert Bremel
  • Publication number: 20050014932
    Abstract: The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing).
    Type: Application
    Filed: May 13, 2004
    Publication date: January 20, 2005
    Applicant: IoGenetics, LLC
    Inventors: Michael Imboden, Jane Homan, Robert Bremel
  • Publication number: 20040088744
    Abstract: The present invention provides methods for the production of a transgenic bovine. In particular, the present invention provides methods for generating transgenic bovines with transgenes that enhance the ability of the bovines to metabolize lipids. The present invention thus provides bovines resistant to fatty liver disease. The compositions and methods of the present invention provide a solution to costly disease.
    Type: Application
    Filed: September 22, 2003
    Publication date: May 6, 2004
    Inventors: Alan Attie, Gregory Bleck, Robert Bremel, Jane Homan