Abstract: A system includes memory, and processing circuitry coupled to the memory, the processing circuitry configured to: determine at least one of: a cross-electrical signal measurement at a first electrode on a first lead implanted within a tongue of the patient based on a stimulation signal between a second electrode on the first lead or a second lead implanted within the tongue of the patient and a third electrode, or a strain measurement of at least one of the first lead or the second lead. The processing circuitry is configured to determine movement of the tongue based on at least one of the cross-electrical signal measurement or the strain measurement, and generate information indicative of the movement of the tongue.

Abstract: A first medical device for obstructive sleep apnea therapy includes therapy delivery circuitry coupled to a first set of electrodes implantable proximate to a first hypoglossal nerve within a tongue of the patient and configured to deliver a first electrical stimulation signal to the first hypoglossal nerve that causes the tongue of the patient to advance and includes information to communicate to a second medical device implantable within the head or neck of the patient and coupled to a second set of electrodes implantable proximate to a second hypoglossal nerve within the tongue of the patient; and sensing circuitry coupled to the first set of electrodes and configured to receive a second electrical stimulation signal, delivered to the second hypoglossal nerve by the second medical device, that includes information that the second medical device communicates to the first medical device.

Abstract: Provided is a multivalent protein that targets interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. The multivalent proteins may also be used to treat subjects having cancer and/or a disease and/or viral infection. Also presented is a multiplex lateral flow test strips for simultaneous detection of the virus and viral antibodies.

Abstract: The present invention relates to inhibitors of protein fucosylation. More specifically, the present invention relates to carbacyclic compounds of Formula (I) useful as inhibitors of protein fucosylation, or for treating a cancer, an autoimmune disease, an infectious disease, an inflammatory disease, or sickle cell disease.

Abstract: Provided is a multivalent protein that targets interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. The multivalent proteins may also be used to treat subjects having cancer and/or a disease and/or viral infection. Also presented is a multiplex lateral flow test strips for simultaneous detection of the virus and viral antibodies.

Abstract: The present invention relates to methods and intermediates for the synthesis of nucleosides and nucleoside analogues (NAs). More specifically, the present invention relates to methods of synthesizing nucleosides and NAs, using simple achiral materials by a ‘one-pot’ proline-catalyzed halogenation of a heteroaryl-substituted acetaldehyde together with a tandem enantioselective aldol reaction followed by a reduction or organometallic addition and cyclization (annulation) reaction involving halide displacement.

Abstract: Disclosed is a composition of volatile and less-volatile pheromone components that can be used alone or in combination with other compounds to attract and/or arrest bed bugs of both sexes and all developmental stages. This blend can be used to bait traps that are effective in capturing bed bugs in infested premises or can be combined with a pesticide that is lethal to bed bugs.

Abstract: The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:

Abstract: Disclosed is a composition of volatile and less-volatile pheromone components that can be used alone or in combination with other compounds to attract and/or arrest bed bugs of both sexes and all developmental stages. This blend can be used to bait traps that are effective in capturing bed bugs in infested premises or can be combined with a pesticide that is lethal to bed bugs.

Abstract: A journal bearing for a crankshaft having indentations on the journal surface is disclosed. The indentations are designed to increase lubricant volume and decrease friction between the journal surface and the bearing surface. The indentations may be designed to intensify the hydrodynamic pressure when the crankshaft is rotating.

Abstract: An insect trap may include a first housing; a reservoir at least partially defined by the first housing; a protrusion disposed within the reservoir and extending inward from an interior surface of the first housing, the protrusion configured to pierce a package disposed within the reservoir; an actuator connected to the protrusion such that when the actuator is moved, the protrusion moves with the actuator within the reservoir; a second housing moveably engaging the first housing; a trap chamber partially formed by the first and second housings; an inlet into the trap chamber; and wherein the second housing is movable between a first position where the inlet is open and a second position where the inlet is closed. The trap may include a package enclosing an attractant composition. The package has a release rate of the attractant composition from about 5 ?g per day to about 500 ?g per day.

Abstract: The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: Disclosed is a six-component composition of volatile and less-volatile pheromone components that can be used alone or in combination with other compounds to attract and/or arrest bed bugs of both sexes and all developmental stages. This blend can be used to bait traps that are effective in capturing bed bugs in infested premises or can be combined with a pesticide that is lethal to bed bugs.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention discloses that essential and highly conserved GTPases (i.e., for example, YlqF, YqeH, YsxC, or YphC proteins) from Bacillus subtilis participate in ribosome biogenesis. Before this invention, the biological function of the GTPase proteins were unknown. These GTPase proteins are disclosed to affect translation and believed to promote ribosome biogenesis. For example, cells depleted of YlqF protein accumulate a precursor of the 50S subunit that migrates at 45S, suggesting a role in assembly of the large ribosomal subunit. Analysis of the protein content of the 45S particle showed that ribosomal protein L16 is missing from the large subunit. Inhibitors of GTPase-ribosomal interactions (i.e., for example, ribosomal protein or ribosomal nucleic acids) comprise a novel class of antimicrobial compounds.

Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.

Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.