Patents by Inventor Robert Brownell
Robert Brownell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230090868Abstract: The invention provides anti-CD30 antibody-drug conjugates, such as brentuximab vedotin, and their use for the treatment of lymphoma, such as diffuse large B-cell lymphoma. The invention also provides the use of anti-CD30 antibody-drug conjugates, such as brentuximab vedotin, in combination with lenalidomide and/or anti-CD20 antibodies, such as rituximab, for the treatment of lymphoma, such as diffuse large B-cell lymphoma.Type: ApplicationFiled: January 29, 2021Publication date: March 23, 2023Inventors: Robert Brownell SIMS, Nancy L. BARTLETT
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Patent number: 10273460Abstract: Methods of detecting target bacteria are provided. In some embodiments, the methods comprise exposing a sample to a phage capable of infecting target bacteria, said phage comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments, the target bacteria comprise Listeria. In some embodiments, the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: GrantFiled: March 31, 2016Date of Patent: April 30, 2019Assignee: Institute for Enviornmental Health, Inc.Inventors: Michael Sandor Koeris, Robert Patrick Shivers, Daniel Robert Brownell, Jason Wyatt Holder, Jayson Linn Bowers
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Publication number: 20180274004Abstract: Composition and methods for the detection of one or more target microbe(s) are provided. Compositions of the disclosure include at least one recombinant phage capable of infecting a target microbe, said phage comprising at least a capsid protein sequence, a ribosome binding site, and a codon-optimized marker. Compositions of the disclosure may further include an aqueous solution that enhances the ability to detect marker expression upon phage infection of the target microbe. In some embodiments the target microbe is Listeria.Type: ApplicationFiled: January 10, 2018Publication date: September 27, 2018Inventors: Michael Sandor Koeris, Michael Cappillino, Edyta Krzymanska-Olejnik, Daniel Robert Brownell, Robert Patrick Shivers, Jayson L. Bowers, Timothy Kuan-Ta Lu
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Patent number: 10039795Abstract: Composition and methods for the detection of one or more target microbe(s) are provided. Compositions of the disclosure include at least one recombinant phage capable of infecting a target microbe, said phage comprising at least a capsid protein sequence, a ribosome binding site, and a codon-optimized marker. Compositions of the disclosure may further include an aqueous solution that enhances the ability to detect marker expression upon phage infection of the target microbe. In some embodiments the target microbe include is Listeria.Type: GrantFiled: May 8, 2015Date of Patent: August 7, 2018Assignee: Institute for Environmental Health, Inc.Inventors: Michael Sandor Koeris, Jayson L. Bowers, Daniel Robert Brownell, Edyta Krzymanska-Olejnik, Robert Patrick Shivers, Michael Cappillino
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Patent number: 9828625Abstract: Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: GrantFiled: June 19, 2014Date of Patent: November 28, 2017Assignee: Phage Diagnostics, Inc.Inventors: Michael Sandor Koeris, Julie Thomason, Michael Cappillino, Robert Patrick Shivers, Daniel Robert Brownell, Jayson L. Bowers, Timothy Kuan Ta Lu, Edyta Krzymanska-Olejnik
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Publication number: 20170044502Abstract: Methods of detecting target bacteria are provided. In some embodiments, the methods comprise exposing a sample to a phage capable of infecting target bacteria, said phage comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments, the target bacteria comprise Listeria. In some embodiments, the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: ApplicationFiled: March 31, 2016Publication date: February 16, 2017Inventors: Michael Sandor Koeris, Robert Patrick Shivers, Daniel Robert Brownell, Jason Wyatt Holder, Jayson Linn Bowers
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Patent number: 9340817Abstract: Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: GrantFiled: March 27, 2014Date of Patent: May 17, 2016Assignee: Sample6 Technologies, Inc.Inventors: Michael Sandor Koeris, Robert Patrick Shivers, Daniel Robert Brownell, Jason Wyatt Holder, Jayson Linn Bowers
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Publication number: 20160122729Abstract: This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage genome is engineered to comprise a heterologous nucleic acid sequence, for example a sequence comprising an open reading frame. In some embodiments the phage genome is cloned in a yeast artificial chromosome. Recombinant phage genomes and recombinant phage are also provided. In some embodiments the methods are high throughput methods such as methods of making aa plurality of recombinant phage genomes or recombinant phage. Collections of recombinant phage genomes and recombinant phage are also provided.Type: ApplicationFiled: January 7, 2016Publication date: May 5, 2016Inventors: Timothy Kuan Ta Lu, Michael Sandor Koeris, Brett Smith Chevalier, Jason Wyatt Holder, Gregory John McKenzie, Daniel Robert Brownell
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Patent number: 9234227Abstract: This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage genome is engineered to comprise a heterologous nucleic acid sequence, for example a sequence comprising an open reading frame. In some embodiments the phage genome is cloned in a yeast artificial chromosome. Recombinant phage genomes and recombinant phage are also provided. In some embodiments the methods are high throughput methods such as methods of making a plurality of recombinant phage genomes or recombinant phage. Collections of recombinant phage genomes and recombinant phage are also provided.Type: GrantFiled: September 26, 2012Date of Patent: January 12, 2016Assignee: Sample6 Technologies, Inc.Inventors: Timothy Kuan Ta Lu, Michael Sandor Koeris, Brett Smith Chevalier, Jason Wyatt Holder, Gregory John McKenzie, Daniel Robert Brownell
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Publication number: 20150344930Abstract: Composition and methods for the detection of one or more target microbe(s) are provided. Compositions of the disclosure include at least one recombinant phage capable of infecting a target microbe, said phage comprising at least a capsid protein sequence, a ribosome binding site, and a codon-optimized marker. Compositions of the disclosure may further include an aqueous solution that enhances the ability to detect marker expression upon phage infection of the target microbe. In some embodiments the target microbe include is Listeria.Type: ApplicationFiled: May 8, 2015Publication date: December 3, 2015Inventors: Michael Sandor KOERIS, Jayson L. BOWERS, Daniel Robert BROWNELL, Edyta KRZYMANSKA-OLEJNIK, Robert Patrick SHIVERS, Michael CAPPILLINO
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Publication number: 20150004595Abstract: Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: ApplicationFiled: June 19, 2014Publication date: January 1, 2015Inventors: Michael Sandor KOERIS, Julie THOMASON, Michael CAPPILLINO, Robert Patrick SHIVERS, Daniel Robert BROWNELL, Jayson L. BOWERS, Timothy Kuan Ta LU, Edyta KRZYMANSKA-OLEJNIK
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Publication number: 20140302487Abstract: Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.Type: ApplicationFiled: March 27, 2014Publication date: October 9, 2014Inventors: Michael Sandor Koeris, Robert Patrick Shivers, Daniel Robert Brownell, Jason Wyatt Holder, Jayson Linn Bowers
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Publication number: 20080161635Abstract: A cartridge may include a housing configured to contain a plurality of like items and a track inside the housing. The track extends in a first direction, and a plunger may be slidable along the track in the first direction and configured to urge the items toward a first end of the housing. The cartridge may include a gate attached to the housing. The gate may be movable between a first position preventing the items from being removed from the housing and a second position allowing one of the items to he removed from the housing. The gate may be configured to remove the one item from being urged by the plunger.Type: ApplicationFiled: June 29, 2007Publication date: July 3, 2008Inventors: Breese J. Watson, Michael W. Drobnik, Jeffrey Neaves, Robert Brownell, Erick Rios
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Publication number: 20070272581Abstract: An energy absorbing container including a shell formed of a plastic material, one or more energy absorbing components for absorbing energy resulting from impact loads, the energy absorbing components securing a bottle stored within the container to prevent movement of the bottle within the container, and an opening mechanism for opening the container and allowing the placement or removal of a bottle therefrom.Type: ApplicationFiled: December 8, 2006Publication date: November 29, 2007Inventors: Benjamin Guelker, Robert Holben, Robert Brownell, Russell Kroll, Suzuko Hisata, Stephen Zwonitzer, Ana Maciel, Steven Vandeberg
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Publication number: 20070014084Abstract: The present invention is a computer controlled display device. In one embodiment, the display device includes a flat panel display having an input for receiving display data. Additionally, a moveable assembly may be coupled to the display. The moveable assembly may provide at least three degrees of freedom of movement for the flat panel display device. Additionally, the moveable assembly may have a cross-sectional area, which is substantially less than a cross-sectional area of a display structure of the flat panel display. Additionally, the moveable assembly may include a plurality of stacked ball-and-socket assemblies.Type: ApplicationFiled: September 19, 2006Publication date: January 18, 2007Inventors: Steven Jobs, Jonathan Ive, Michael Hillman, Frank Tsai, Michael McBroom, Daniel McBroom, Brian Sudderth, Arthur Brigham, Joel Jensen, Robert Brownell, Sung Kim, Anwyl McDonald, Russell Mead, Arturo Meuniot, Jesus Beltran, Bartley Andre, Christopher Stringer, Daniel Riccio
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Publication number: 20050088814Abstract: The present invention is a computer controlled display device. In one embodiment, the display device includes a flat panel display having an input for receiving display data. Additionally, a moveable assembly may be coupled to the display. The moveable assembly may provide at least three degrees of freedom of movement for the flat panel display device. Additionally, the moveable assembly may have a cross-sectional area, which is substantially less than a cross-sectional area of a display structure of the flat panel display. Additionally, the moveable assembly may include a plurality of stacked ball-and-socket assemblies.Type: ApplicationFiled: October 25, 2004Publication date: April 28, 2005Inventors: Steven Jobs, Jonathan Ive, Michael Hillman, Frank Tsai, Michael McBroom, Daniel McBroom, Brian Sudderth, Arthur Brigham, Joel Jensen, Robert Brownell, Sung Kim, Anwyl McDonald, Russell Mead, Arturo Meuniot, Jesus Beltran, Bartley Andre, Christopher Stringer, Daniel Riccio