Abstract: A pen needle and a method of using the pen needle. The pen needle includes a housing, a needle carrier in the housing supporting a needle, a distal shroud positioned around the needle within the housing, a distal compression spring positioned around the needle between the needle carrier and the distal shroud, a proximal shroud positioned around the needle within the housing, and a proximal compression spring positioned around the needle between the needle and the proximal shroud. The proximal shroud is movable between a first position, in which the proximal shroud engages the distal shroud to hold the distal shroud in engagement with the housing, and a second position in which the proximal shroud is disengaged from the distal shroud allowing the distal shroud to move in a distal direction to project from the housing and surround a distal end of the needle.

Abstract: An auto-injector for receiving and operating a syringe. The auto-injector includes a housing for receiving the syringe, the housing comprising a main body and a hinged door operable into an open position and a closed position. The syringe is receivable within the housing when the hinged door is in the open position. At least one charging link is connected between the main body and the hinged door, wherein a connection of the at least one charging link to the main body and/or a connection of the at least one charging link to the hinged door is a slidable connection configured to slide on opening and closing of the hinged door and configured to couple to at least one drive spring for priming of the at least one drive spring on the opening of the hinged door and/or the closing of the hinged door. The at least one drive spring is configured on activation of the auto-injector to drive a plunger driver forward within the auto-injector to operate the syringe received within the auto-injector.

Abstract: A pen needle and a method of using the pen needle. The pen needle includes a housing, a needle carrier in the housing supporting a needle, a distal shroud positioned around the needle within the housing, a distal compression spring positioned around the needle between the needle carrier and the distal shroud, a proximal shroud positioned around the needle within the housing, and a proximal compression spring positioned around the needle between the needle and the proximal shroud. The proximal shroud is movable between a first position, in which it engages the distal shroud to hold it in engagement with the housing, and a second position in which the proximal shroud is disengaged from the distal shroud allowing the distal shroud to move in a distal direction to project from the housing and surround the end of the needle.

Abstract: An auto-injector for receiving and operating a syringe, the auto-injector comprising: a housing for receiving the syringe, the housing comprising a main body and a hinged door operable into an open position and a closed position, wherein the syringe is receivable within the housing when the hinged door is in the open position; at least one charging link connected between the main body and the hinged door, wherein the connection of the charging link to the main body and/or the connection of the charging link to the hinged door is a slidable connection configured to slide on opening and closing of the hinged door and configured to couple to the at least one drive spring for priming thereof on opening and/or closing of the hinged door, the at least one drive spring being configured on activation of the auto-injector to drive a plunger driver forward within the auto-injector to operate the syringe received within the auto-injector.

Abstract: An auto-injector for receiving a primed syringe includes: a plunger driver for coupling to a plunger head of the syringe when the syringe is fitted within the auto-injector, and configured to drive a plunger into a barrel of the syringe, wherein the plunger driver positioned on the auto-injector such that it is below the plunger head when the syringe is primed and fitted within the auto-injector.

Abstract: A device for mixing bone cement material, the device comprising a mixing body having a chamber, and wherein the mixing body has an open end; a lid arranged to be fitted to the open end; means for mixing bone cement material in the chamber, the means for mixing comprising a rod extending through the lid and into the chamber, wherein the rod has a frangible portion; said lid comprising a cap moveable to a first position covering the frangible portion of the rod, and to a second position revealing the frangible portion.

Abstract: A device for mixing bone cement material, the device comprising a mixing body having a chamber, and wherein the mixing body has an open end; a lid arranged to be fitted to the open end; means for mixing bone cement material in the chamber, the means for mixing comprising a rod extending through the lid and into the chamber, wherein the rod has a frangible portion; said lid comprising a cap moveable to a first position covering the frangible portion of the rod, and to a second position revealing the frangible portion.

Abstract: Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.

Abstract: Novel 2-(azetidin-2-on-1-yl) alkanedioic acid derivativies and 2-(azetidin-2-on-1-yl) alkoxyalkanoic acid derivativies are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.

Abstract: Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor.