Abstract: A system and corresponding method are provided for identifying a subpopulation of cancer patients who are immunotherapy respondents. An effective method of assessing neoantigen presentation is provided. A vaccine composition is also provided. The vaccine composition is prepared by feeding data for a subject with a type of cancer into a predictive model and scoring neoantigens that occur in data for the subject for one or more parameters. One or more vaccine compositions to be administered to the subject are prepared for one or more somatic mutations for one or more neoantigens that satisfy an immune stimulation threshold.

Abstract: Provided is a system and method to authenticate multiple users in order to secure sensitive cloud assets. The system comprises a user device, a service provider, and an identify provider. The service provider provides services for producing and consuming data. The identify provider authenticates and authorizes multiple authorizors for providing user access to the resources and data. A device app communicates with the service provider and identify provider. The device app polls votes and determines when a quorum approval for utilizing data is met within a constraint. It authorizes the user temporary access to the data for use by one of the services upon quorum approval, and enforces temporal and physical conditions on it. The access can be granted via a push action or a pull notification. Other embodiments are disclosed.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: Provided is a system and method to authenticate multiple users in order to secure sensitive cloud assets. The system comprises a user device, a service provider, and an identify provider. The service provider provides services for producing and consuming data. The identify provider authenticates and authorizes multiple authorizors for providing user access to the resources and data. A device app communicates with the service provider and identify provider. The device app polls votes and determines when a quorum approval for utilizing data is met within a constraint. It authorizes the user temporary access to the data for use by one of the services upon quorum approval, and enforces temporal and physical conditions on it. The access can be granted via a push action or a pull notification. Other embodiments are disclosed.

Abstract: A closure system for a boot or other footwear includes a tension member that is disposed within the boot and routed or guided about a path within the boot via one or more guides. The closure system also includes an adjustment member that is disposed within the boot and operably coupled with the tension member. The closure system further includes a reel based closure device having a knob that is operable to tension the tension member and to release tension from the tension member. Tensioning of the tension member adjusts a fit of the adjustment member about a foot within the boot to secure the foot within the boot and loosening of the tension member adjusts the fit of the adjustment member about the foot to allow the foot to be more easily removed from the boot.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: The present invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to a use of said vectors in the manufacture of a medicament for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing B7 family of immune-regulatory ligands and ADA in a cell and increasing anti-tumor effect and induction of specific immune response in a subject, as well as uses of the oncolytic adenoviral vector of the invention for producing transgenes in a cell and increasing anti-tumor effect and generation of specific immune response in a subject.

Abstract: The present invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to a use of said vectors in the manufacture of a medicament for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing peptidylarginine deiminase and TIMP in a cell and increasing anti-tumor effect and induction of specific immune response in a subject, as well as uses of the oncolytic adenoviral vector of the invention for producing transgenes in a cell and increasing anti-tumor effect and generation of specific immune response in a subject.

Abstract: An intermediary system, between broker and client systems receives, from the broker system, an electronic message including an indication of interest (IOI) to execute a trade. The intermediary system identifies an interest of a trader in the trade of the IOI and routes the electronic message to the trader's client system. The identified interest is undisclosed by the trader to the broker and intermediary systems but is inferred based on the trader's trading activity (e.g., the trader's blotter data). The intermediary system routes the electronic message including the IOI to the client system and responds to an indication that the trader triggered an action at the client system to execute the trade by causing the order to fill.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. Mixed in the composition is at least one catechin 0.01 to 0.05% by weight. The alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose.

Abstract: Closure devices that may be used for various articles, such as braces, medical devices, shoes, clothing, apparel, and the like. The closure devices may include a tightening mechanism that may function as a handle that allows an individual to wrap an article around body part, couple the article about the body part, and then tension or tighten the article using a single hand.

Abstract: Various embodiments relate generally to a system, a device and a method for providing a panel-based search interface as a function of incremental entry of user data, such as text representing a destination. Data representing user input is received at a search interface presented by a listing management system. One or more panel objects are determined based on the user input. Data representing one or more interests associated with the user input is retrieved. The one or more panel objects and the data representing the one or more interests are rendered within the search interface. Responsive to the received user input, the search interface comprising the rendered one or more panel objects and the data representing the one or more interests is provided.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: A closure system for a boot or other footwear includes a tension member that is disposed within the boot and routed or guided about a path within the boot via one or more guides. The closure system also includes an adjustment member that is disposed within the boot and operably coupled with the tension member. The closure system further includes a reel based closure device having a knob that is operable to tension the tension member and to release tension from the tension member. Tensioning of the tension member adjusts a fit of the adjustment member about a foot within the boot to secure the foot within the boot and loosening of the tension member adjusts the fit of the adjustment member about the foot to allow the foot to be more easily removed from the boot.

Abstract: A closure system for a boot or other footwear includes a tension member that is disposed within the boot and routed or guided about a path within the boot via one or more guides. The closure system also includes an adjustment member that is disposed within the boot and operably coupled with the tension member. The closure system further includes a reel based closure device having a knob that is operable to tension the tension member and to release tension from the tension member. Tensioning of the tension member adjusts a fit of the adjustment member about a foot within the boot to secure the foot within the boot and loosening of the tension member adjusts the fit of the adjustment member about the foot to allow the foot to be more easily removed from the boot.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: A lacing system for tightening an article includes a first guide that is coupled with the article and positioned within a first zone of the article and a second guide that is coupled with the article and positioned within a second zone of the article with at least a portion of the second zone being different than the first zone. A first tension member is guided by the first guide within the first zone and a second tension member is guided by the second guide within the second zone. Tensioning of the first tension member or second tension member causes tightening of the respective zone of the article. A tensioning mechanism is also coupled with the article and with the first and second tension members. The tensioning mechanism is configured to tension the first and second tension members to tighten the first and second zones of the article.

Abstract: Oral formulation of particles made of an agglomeration of a plurality of seed granules or a single seed granule both surrounded by three layers and an outer gel coating. The seed granules are made of calcium carbonate with microscopic fissures. Disposed inside the fissures and in the interstitial spaces of the agglomerate seed granules are microscopic particles of alkali metal salts and other ions. Coating the agglomerate or single seed granules is an alkaline-resistant first layer made of microcrystalline cellulose and croscarmellose sodium that binds and protects the surrounding second layer. Surrounding the first layer is a second layer comprising a mixture of a flavonoid and polysaccharide or polypeptide binder or polymer gel. Surrounding the second layer is a third layer made of alkaline earth metal salt particles holding alkali metal hydroxide ions within a polysaccharide or polymer gel. Surrounding the third layer is at least one outer gel layer.