Abstract: Described herein are compositions and methods for preparing double-stranded complementary DNA (cDNA) from RNA. In some embodiments, these methods allow isothermal preparation of cDNA. In some embodiments, these methods allow mesophilic or thermostable preparation of cDNA. Also described herein are compositions and methods for preparing cDNA and a library of double-stranded cDNA fragments in a single reaction vessel.

Abstract: A system and method of analyzing, manipulating, and combining various items of resource consuming device (“RCD”) performance information to produce quantitative metrics usable to rank or compare RCDs. The method can apply to RCDs such as cars, appliances, residential households or electronics.

Abstract: The present disclosure is directed to methods of improving the therapeutic effectiveness and safety profile of ibogaine for the treatment of conditions including, but not limited to, alcoholism, substance abuse disorder, and opioid use disorder.

Abstract: Compositions and methods for reducing the toxic effect of certain peptide toxins by administering an agent that directly or indirectly reduces disulfide bonds that are important for maintaining the toxin in an active conformation. Also described are compositions and methods for reducing the toxic effect of toxins that contain a heavy metal using an agent that destabilizes the binding of a metal ion that is important for toxin activity.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.

Abstract: A method and system for visually guiding an aircraft in its landing approach to a runway having an approach area equipped with approach lights operable in off, low, medium, and high intensity states. The lights are communicated with a secondary side of a transformer, which has a primary side with low, medium, and high taps that correspond to the light states. Off, low, medium, and high lighting intensity requests correspond to the low, medium, and high states of the plurality of lights. AC power is switched between the transformer taps in response to a request for an increase in lighting intensity. Power is sequentially applied to the taps by supplying the power to the low tap for a first predetermined time interval before supplying the power to the medium tap.

Abstract: A method and system for visually guiding an aircraft in its landing approach to a runway having an approach area equipped with approach lights operable in off, low, medium, and high intensity states. The lights are communicated with a secondary side of a transformer, which has a primary side with low, medium, and high taps that correspond to the light states. Off, low, medium, and high lighting intensity requests correspond to the low, medium, and high states of the plurality of lights. AC power is switched between the transformer taps in response to a request for an increase in lighting intensity. Power is sequentially applied to the taps by supplying the power to the low tap for a first predetermined time interval before supplying the power to the medium tap.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: This invention relates to isoxazole-based inhibitors of fungal invasion.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: A pivoted operator d(4) for an electric switch has an inwardly extending actuating leg (4d) having direct connection with a contactor (12) to provide over-center pivoting and sliding motion for the contactor. The inner end of the actuating leg has a first slot (4f) wherein the actuator leg straddles the contactor and has grooved (4h) interior surfaces which receive outward lateral projections (12a) on the contactor for affecting a driving connection therebetween. The depending leg has a cylindrical recess (4e) which receives a helical compression spring (14) to bear between the operator and the contactor. Transversely aligned connection points (12a, 4h) actuator and contactor and the edges of the slot (4f) in the actuator cooperating with the lateral edges of the contactor (12) guide the latter throughout its longitudinal movement to prevent angular displacement in a horizontal plane of the contactor within the switch.