Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.

Abstract: A lighting fixture may include a housing, an illumination source disposed within the housing, and a frame coupled to the housing. The frame may include a first side and a second side abutting the first side to form a joint, wherein a gap extends at the joint and at least one of the first side or the second side is configured to obscure at least a portion of the gap.

Abstract: A network interface card (NIC) receives a stream of commands, a respective command comprising memory-operation requests, each request associated with a destination NIC. The NIC buffers asynchronously the requests into queues based on the destination NIC, each queue specific to a corresponding destination NIC. When first queue requests reach a threshold, the NIC aggregates the first queue requests into a first packet and sends the first packet to the destination NIC. The NIC receives a plurality of packets, a second packet comprising memory-operation requests, each request associated with a same destination NIC and a destination core. The NIC buffers asynchronously the requests of the second packet into queues based on the destination core, each queue specific to a corresponding destination core. When second queue requests reach the threshold, the NIC aggregates the second queue requests into a third packet and sends the third packet to the destination core.

Abstract: Systems and methods for regulating electronic messages transmissions. A message delay system is disposed between one or more first entities and a second entity within at least one network. Electronic messages are received from among at least one the first entities and the second entity at one or more message arrival times. A message delay component applies a delay to each received electronic message, based on a predefined delay time common to all of the first entities and a first entity delay offset associated with a first entity that is associated with the received message. The first entity delay offset is based on a geographical origin of the first entity relative to a geographical origin of the second entity. Each delayed message is transmitted to a designated recipient via the network, where the designated recipient is among the second entity and the first entities.

Abstract: A system and method for resolving an error condition of a medical device includes the medical device, a mobile device, and a host computer. The medical device generates a machine readable code, the machine readable code is read by the mobile device, and the remote computer hosts a uniform resource locator (URL) associated with the machine readable code such that the mobile device can access the URL.

Abstract: Embodiments herein disclose e.g. a method performed by a wireless device (10) for handling communication for the wireless device in a second wireless communication network. The second wireless communication network coexists with a first wireless communication network on a same bandwidth in frequency, wherein the first wireless communication network applies a first shift in frequency in uplink transmissions. The wireless device receives from a radio network node (12, 13), an indication indicating application of a second shift in frequency to uplink transmissions in case the second wireless communication network uses Frequency Division Duplex (FDD). The wireless device further applies the second shift in frequency to uplink transmissions, wherein the second shift defines a shift in frequency to a subcarrier relative to a subcarrier grid of the second wireless communication network or a shift in frequency to the subcarrier grid of the second wireless communication network.

Abstract: An implantable medical device has a therapy module configured to generate a composite pacing pulse including a series of at least two individual pulses. The therapy module is configured to generate the composite pacing pulse by generating a first pulse of the at least two individual pulses by selectively coupling a first portion of a plurality of capacitors to an output signal line and generate a second pulse of the at least two individual pulses by selectively coupling a second portion of the plurality of capacitors to the output signal line.

Abstract: Provided is a process that establishes user identities within a decentralized data store, like a blockchain. A user's mobile device may establish credential values within a trusted execution environment of the mobile device. Representations of those credentials may be generated on the mobile device and transmitted for storage in association with an identity of the user established on the blockchain. Similarly, one or more key-pairs may be generated or otherwise used by the mobile device for signatures and signature verification. Private keys may remain resident on the device (or known and input by the user) while corresponding public keys may be stored in associated with the user identity on the blockchain. A private key is used to sign representations of credentials and other values as a proof of knowledge of the private key and credential values for authentication of the user to the user identity on the blockchain.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present disclosure relates to fibrous structures including active agents and having a graphic printed thereon. In some embodiments, a nonwoven web may include a fibrous structure comprising filaments. In turn, the filaments may include filament forming material, and an active agent releasable from the filaments when exposed to conditions of intended use. In addition, a graphic may be printed directly onto the fibrous structure.

Abstract: A method, apparatus, apparatus, and computer program product for managing an autonomous aerial vehicle. A copy of a mission plan is stored in a mission work queue. The mission plan is located in the autonomous aerial vehicle and comprises mission components that define tasks performed by the autonomous aerial vehicle. A change to the mission components in the copy of the mission plan in the mission work queue is received to form a modified mission component in the copy of the mission plan. A determination is made as to whether the copy of the mission plan including the modified mission component can be executed by the autonomous aerial vehicle. The copy of the mission plan including the modified mission component is synchronized with the mission plan in the autonomous aerial vehicle such that the mission plan includes the modified mission component. The autonomous aerial vehicle executes the mission plan.

Abstract: A blaster for shooting projectiles that includes a housing that defines a housing interior, and a variable velocity barrel assembly positioned in the housing interior. The variable velocity barrel assembly includes a barrel that defines a barrel axis and a barrel interior. The barrel includes an exit opening at a distal end thereof. At least a first opening communicates the barrel interior with an exterior of the barrel. The first opening is defined through a side wall of the barrel. A slider member that includes a cylindrical portion that surrounds the barrel is movable axially along the barrel between a maximum velocity position where the cylindrical portion covers the first opening and a minimum velocity position where the slider member does not cover the first opening.

Abstract: A process and apparatus for handling a rigid sheet is disclosed. The process comprises engaging opposing faces of a sheet at its periphery with engagement means providing a second engagement means, movable relative to the first and engaging the sheet with the second engagement means. The sheet is then moved relative to the second engagement means whilst the sheet is engaged with the first engagement means and is then clamped. The sheet is then moved to a desired orientation or location whilst maintaining the first and second engagement means in fixed relative position. The process is useful in handling glass sheeting and in the production of multiple glazed units and on an insulating glass production line.

Abstract: A method of calibrating a transmitter chain in a phased array system in which a lower guard band is assigned to a lower side of an operating carrier of a communication channel and an upper guard band is assigned an upper side of the operating carrier includes injecting a first calibration tone into the transmitter chain and detecting its arrival at the end of the transmitter chain, at which point a first detected calibration signal is generated. The first detected calibration signal and the injected first calibration tone are then compared to produce a first comparison signal. The transmitter chain's phase and/or gain is then adjusted based on this first comparison signal. The first calibration tone located within one of the lower and upper guard bands of the communication channel of the transmitter chain.

Abstract: Methods, systems, and devices that support variable modulation schemes for memory are described. A device may switch between different modulation schemes for communication based on one or more operating parameters associated with the device or a component of the device. The modulation schemes may involve amplitude modulation in which different levels of a signal represent different data values. For instance, the device may use a first modulation scheme that represents data using two levels and a second modulation scheme that represents data using four levels. In one example, the device may switch from the first modulation scheme to the second modulation scheme when bandwidth demand is high, and the device may switch from the second modulation scheme to the first modulation scheme when power conservation is in demand. The device may also, based on the operating parameter, change the frequency of the signal pulses communicated using the modulation schemes.

Abstract: An elevator system including: an elevator car configured to travel through an elevator shaft; a first guide beam extending vertically through the elevator shaft, the first guide beam comprising a first surface and a second surface opposite the first surface; a propulsion system configured to move the elevator car through the elevator shaft; a first on-board energy management system configured to power the propulsion system, the first on-board energy management system is attached to the propulsion system and configured to travel with the propulsion system.

Abstract: 1.

Abstract: A knee pad assembly includes a protective member, a hard shell member and a hinge member connecting the protective member and the hard shell member. A first end of the hard shell member is connected to the hinge member. A second end of the hard shell member opposing the first end has an upper lip member and a lower lip member, the upper lip member and the lower lip member defining a recessed member that extends from one side of second end of the hard shell member to another side of the second end of the hard shell member.

Abstract: A gas turbine engine and engine mount structure includes a core engine including a compressor section, a combustor section and a turbine section mounted within a core engine housing. The fan, the compressor section and the turbine section rotate about an axis of rotation. An outer nacelle surrounds the fan, and is spaced from the core engine housing to define a bypass duct. The fan delivers air into the bypass duct and into the core engine housing. The nacelle is formed with camber so as to be curved in a first plane away from the axis of rotation in a first lateral direction. An engine mount structure extends from the nacelle at an angle that is non-parallel and non-perpendicular to the first plane, and has a component in a lateral direction that is opposed to the first lateral direction. An aircraft is also disclosed.

Abstract: Techniques described herein relate to a method for deploying workflows.