Abstract: Some embodiments of the present disclosure relate to an additively manufactured transport structure. The transport structure includes cavities into which components that use an external interface are inserted. A plurality of components are assembled and integrated into the vehicle. In an embodiment, the components and frame are modular, enabling reparability and replacement of single parts in the event of isolated failures.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: Described are liposomal formulation for the improved delivery of boronic acid esters of boronic acid therapeutic agents. The liposomal formulation can include (i) liposomes formed from a vesicle-forming lipid; and (ii) a capturing agent-active agent complex encapsulated in the liposomes.

Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.

Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.

Abstract: A method of detecting foreign objects in crop material includes transferring a cut crop material through a sensing area. Electrodes are arranged around a periphery of the sensing area. A first electromagnetic field is generated by broadcasting first electromagnetic radiation from a first electrode into the sensing area. A first attribute related to the first electromagnetic field is measured at some of the electrodes. A second electromagnetic field is generated by broadcasting second electromagnetic radiation from a second electrode into the sensing area. A second attribute related to the second electromagnetic field is measured at some of the electrodes. The first and second attributes are correlated to a property of a material in the sensing area, and thus, foreign objects may be detected in crop material. Related systems are also disclosed.

Abstract: The present invention provides, in part, protein-drug conjugates comprising an anti-fibroblast growth factor receptor 3 (FGFR3) (e.g., human FGFR3) antigen-binding protein (e.g., scFv, Fab) conjugated to a molecular cargo (e.g., polynucleotides, polypeptides, liposomes or lipid nanoparticles) for delivery of the molecular cargo to a targeted tissue (e.g., brain). Methods for treating various diseases or disorders, such as neurological diseases, with the conjugates are provided.

Abstract: Pharmaceutical compositions of anti-TSLP-R antibodies, and uses thereof, are provided herein. The pharmaceutical compositions can comprise for example, an anti-TSLP-R antibody, or antigen-binding fragment thereof, a pharmaceutically acceptable buffer, an excipient, and a surfactant, or other compositions as provided for herein.

Abstract: A dual lumen coaxial cannula assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit. The first infusion tube and the second drainage tube include a plurality of infusion and drainage apertures, respectively, provided at the distal end and extending through the sidewall of the first infusion tube and the drainage tube, respectively.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: A tire including a decoupling groove is provided, the tire comprising: a body, a shoulder, a tread surface including at least one decoupling groove extending radially inwardly into the body from the tread surface, and a plurality of parallel sipes, wherein the decoupling groove is oriented adjacent to the shoulder, wherein the decoupling groove is defined by an axially outer groove sidewall and an axially inner groove sidewall, has a width W1, and has a centerline, wherein the plurality of parallel sipes extend axially into the inner groove sidewall, wherein the decoupling groove has a radially inner groove base defined by a curvilinear base surface, has a width W2, and has a center, wherein the width W2 is greater than the width W1, and wherein a centerline of the decoupling groove intersects the center of the groove base.

Abstract: Described herein are therapeutic compositions comprising a rhamnolipid impregnated within an electrospun support, and methods of using the same. Exemplary therapeutic compositions may be used for wound treatment.

Abstract: A battery powered welding system is provided. In one welding system a battery powered welder includes control circuitry configured to control a welding power output converted from power from an external battery power source. The battery powered welder also includes a wire drive assembly coupled to the control circuitry and configured to feed a welding wire using power from the external battery power source. The battery powered welder includes a case integrally supporting and enclosing the control circuitry and the wire drive assembly. The case is not configured to enclose the external battery power source.

Abstract: An automated peritoneal dialysis apparatus includes at least one pump and a memory device configured to simultaneously store a first standard ultrafiltration (“UF”) therapy prescription with a longer duration and a lower dextrose concentration and a second standard UF therapy prescription with a shorter duration and a higher dextrose concentration. A logic implementer of the automated peritoneal dialysis apparatus is programmed to receive a patient weight value and determine a weight difference between the patient weight value and at least one prior patient weight value. When the weight difference is below a threshold, the logic implementer causes the first standard UF therapy prescription and the second standard UF therapy prescription to be displayed as possible options for selection and when the weight difference is above the threshold, the logic implementer prevents the second standard UF therapy prescription from being displayed as a possible option for selection.

Abstract: A method of plugging channels of a honeycomb body and a honeycomb body including plugged channels. The method includes applying a shear force to a plugging mixture including a plurality of inorganic particles, clay, and a liquid vehicle to alter the viscosity of the plugging mixture from a first viscosity prior to the vibrating to a second viscosity which is less than the first viscosity. A honeycomb body is placed into contact with the plugging mixture such that a portion of the plugging mixture having the second viscosity flows into the plurality of channels. Application of the shear force is stopped or reduced to increase the viscosity of the portion of the plugging mixture in the plurality of channels to greater than the first viscosity.

Abstract: A handheld ultrasound device and corresponding methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. The methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.

Abstract: The disclosure relates to relates to heterogeneous catalysts useful for the synthesis of ammonia under electromagnetic irradiation, processes for preparing the disclosed heterogeneous catalysts, processes for synthesizing ammonia at ambient pressures using hydrogen and nitrogen. The disclosed heterogeneous catalysts can be utilized in disclosed processes for efficient synthesis of ammonia utilizing a variable frequency reactor with an electromagnetic frequency generator and a reactor chamber. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An adapter for a fire extinguisher includes a cylinder which has an internal volume for storage of an extinguishing agent and a neck through which the internal volume may be accessed, a release valve, and a dip tube. The adapter defines a first flow path through the adapter for the extinguishing agent during introduction or charging of the extinguishing agent into the internal volume of the cylinder. The adapter at least partially defines or accommodates a second flow path for the extinguishing agent through the adapter during discharging of the fire extinguisher of which the adapter is part. The first and second flow paths are different.

Abstract: Various aspects of the present disclosure relate to a method of cleaning a glass substrate. The method includes contacting the glass substrate with a cleaning agent for a predetermined amount of time. The cleaning agent includes a substance having a sublimation point in a range of from about ?90° C. to about ?70° C. and the cleaning agent is dispersed in a gas carrier.