Patents by Inventor Robert C. A. Frederickson
Robert C. A. Frederickson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100087728Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 8, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Publication number: 20100081893Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 1, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Patent number: 7547283Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.Type: GrantFiled: June 3, 2004Date of Patent: June 16, 2009Assignee: PhysioSonics, Inc.Inventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C. A. Frederickson
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Patent number: 6756362Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: May 6, 2002Date of Patent: June 29, 2004Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 6417173Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: December 30, 1999Date of Patent: July 9, 2002Assignee: Gliatech, Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 6127348Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: September 1, 1999Date of Patent: October 3, 2000Assignee: Gliatech, Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 6083930Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: June 6, 1995Date of Patent: July 4, 2000Assignee: Gliatech Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson
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Patent number: 5994325Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: June 6, 1995Date of Patent: November 30, 1999Assignee: Gliatech Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 5705178Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.Type: GrantFiled: December 8, 1993Date of Patent: January 6, 1998Assignee: Gliatech, Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 5705177Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: July 26, 1994Date of Patent: January 6, 1998Assignee: Gliatech Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 5605938Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that he effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.Type: GrantFiled: May 31, 1991Date of Patent: February 25, 1997Assignee: Gliatech, Inc.Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
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Patent number: 4430327Abstract: A method is described for preventing or minimizing the effects of a drug on an embryo or a fetus by placental transport while alleviating pain and anxiety of the pregnant female by administering a pharmaceutically effective amount of a compound of the formulaH-L-Tyr-D-Ala-Gly-L-Phe-L-(N-CH.sub.3)Met-NH.sub.2or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 18, 1982Date of Patent: February 7, 1984Assignee: Eli Lilly and CompanyInventor: Robert C. A. Frederickson
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Patent number: 4331593Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality;R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.3 is C.sub.1 -C.sub.4 primary or secondary alkyl or --CH.sub.2 CH.sub.2 --S--CH.sub.3 ;R.sub.4 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl; andZ is ##STR2## --CH.sub.2 OH, or --CN; subject to the limitation that no more than one of R.sub.4 and R.sub.5 is C.sub.1 -C.sub.3 primary alkyl; are useful analgesic agents.Type: GrantFiled: October 31, 1980Date of Patent: May 25, 1982Inventors: Edward L. Smithwick, Jr., Robert C. A. Frederickson, Robert T. Shuman
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Patent number: 4322342Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which:L and D, when applicable, define the chirality;R.sub.1 is hydrogen, C.sub.1 -C.sub.3 primary alkyl, or allyl;R.sub.2 is hydrogen or C.sub.1 -C.sub.3 primary alkyl, subject to the limitation that when R.sub.1 is allyl, R.sub.2 is hydrogen;R.sub.3 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.4 is C.sub.1 -C.sub.4 primary or secondary alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.4 primary or secondary alkyl;R.sub.6 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.7 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl;Z is hydrogen or ##STR2## in which R.sub.8 is C.sub.1 14 C.sub.3 alkyl or hydrogen; and W is isopropyl, --VR.sub.9, or --CH.sub.2 --X--CH.sub.3, in which V is O or S, R.sub.9 is C.sub.1 -C.sub.4 alkyl or aralkyl, and X is O, S, or --CH.sub.2 --, subject to the limitation that, when W is isopropyl, R.sub.7 is C.sub.1 -C.sub.Type: GrantFiled: October 31, 1980Date of Patent: March 30, 1982Assignee: Eli Lilly and CompanyInventors: Edward L. Smithwick, Jr., Robert C. A. Frederickson, Robert T. Shuman
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Patent number: 4264491Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality;R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.3 is C.sub.1 -C.sub.4 primary or secondary alkyl or --CH.sub.2 CH.sub.2 --S--CH.sub.3 ;R.sub.4 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl; andZ is ##STR2## --CH.sub.2 OH, or --CN; subject to the limitation that no more than one of R.sub.4 and R.sub.5 is C.sub.1 -C.sub.3 primary alkyl; are useful analgesic agents.Type: GrantFiled: October 3, 1977Date of Patent: April 28, 1981Assignee: Eli Lilly and CompanyInventors: Edward L. Smithwick, Jr., Robert C. A. Frederickson, Robert T. Shuman
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Patent number: 4259234Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality;R.sub.1 is hydrogen, C.sub.1 -C.sub.3 primary alkyl, or allyl;R.sub.2 is hydrogen or C.sub.1 -C.sub.3 primary alkyl, subject to the limitation that when R.sub.1 is allyl, R.sub.2 is hydrogen;R.sub.3 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.4 is C.sub.1 -C.sub.4 primary or secondary alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.4 primary or secondary alkyl;R.sub.6 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.7 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl;Z is hydrogen of ##STR2## in which R.sub.8 is C.sub.1 -C.sub.3 alkyl or hydrogen; and W is isopropyl, --VR.sub.9, or --CH.sub.2 --X--CH.sub.3, in which V is O or S, R.sub.9 is C.sub.1 -C.sub.4 alkyl or aralkyl, and X is O, S, or --CH.sub.2 --, subject to the limitation that, when W is isopropyl, R.sub.7 is C.sub.1 -C.sub.Type: GrantFiled: June 20, 1977Date of Patent: March 31, 1981Assignee: Eli Lilly and CompanyInventors: Edward L. Smithwick, Jr., Robert C. A. Frederickson, Robert T. Shuman
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Patent number: 4199499Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality;R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.3 is C.sub.1 -C.sub.4 primary or secondary alkyl, C.sub.1 -C.sub.2 hydroxyalkyl, or --CH.sub.2 CH.sub.2 --U--CH.sub.3, in which U is O or S;R.sub.4 is C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl;Z is --CH.sub.2 OH or ##STR2## in which R.sub.5 is C.sub.1 -C.sub.3 alkyl or hydrogen; and W is isopropyl, --VR.sub.6, or --CH.sub.2 --X--CH.sub.3, in which V is O or S, R.sub.6 is C.sub.1 -C.sub.4 alkyl or aralkyl, and X is O, S, or CH.sub.2 --; are useful analgesic agents.Type: GrantFiled: August 24, 1978Date of Patent: April 22, 1980Assignee: Eli Lilly and CompanyInventors: Edward L. Smithwick, Jr., Robert C. A. Frederickson, Robert T. Shuman
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Patent number: 4085705Abstract: A ventilated animal cage system is provided in which a plurality of animal cages are removably suspended on shelves of a portable rack. Each shelf is hollow to form an air duct that is in communication with the cages suspended therefrom, thus minimizing the possibility of cross-contamination between animals in the cages and personnel in the laboratory room.Type: GrantFiled: September 17, 1976Date of Patent: April 25, 1978Assignee: Eli Lilly and CompanyInventors: Thomas M. Gland, Robert C. A. Frederickson