Patents by Inventor Robert C. Dean
Robert C. Dean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5605623Abstract: Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.Type: GrantFiled: January 20, 1995Date of Patent: February 25, 1997Assignee: PerSeptive Biosystems, Inc.Inventors: Noubar B. Afeyan, Fred E. Regnier, Robert C. Dean, Jr.
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Patent number: 5597497Abstract: A switch mechanism with a safety member for operating a tool or a weapon which reduces the probability of inadvertent operation. The switch mechanism comprises a trigger and a safety member disposed adjacent to the trigger for preventing the trigger from contacting an actuation switch. The safety member is shaped such that when it is positioned in a first position, it prevents the trigger from contacting the switch. In addition, the safety member is shaped such that when the safety member is positioned in a second position, it allows the trigger to contact the actuation switch.Type: GrantFiled: December 20, 1994Date of Patent: January 28, 1997Assignee: Hypertherm, Inc.Inventors: James C. Dean, Robert C. Dean, Jr., E. Hubbard Yonkers
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Patent number: 5552041Abstract: Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.Type: GrantFiled: October 3, 1994Date of Patent: September 3, 1996Assignee: PerSeptive Biosystems, Inc.Inventors: Noubar B. Afeyan, Fred E. Regnier, Robert C. Dean, Jr.
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Patent number: 5384042Abstract: Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.Type: GrantFiled: May 10, 1993Date of Patent: January 24, 1995Assignee: PerSeptive Biosystems, Inc.Inventors: Noubar B. Afeyan, Fred E. Regnier, Robert C. Dean, Jr.
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Patent number: 5228989Abstract: Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.Type: GrantFiled: December 9, 1992Date of Patent: July 20, 1993Assignee: PerSeptive Biosystems, Inc.Inventors: Noubar B. Afeyan, Fred E. Regnier, Robert C. Dean, Jr.
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Patent number: 5100783Abstract: Weighted microsponges formed of a porous, biostable matrix of a biocompatible polymer containing an inert weighing material are prepared suitable for use in culturing organisms in motive reactor systems. The matrix has an open to the surface pore structure with an average pore size in the range of from about 1 to about 150 microns and the pores occupy from about 70 to about 98% by volume of the microsponge. The microsponges have an average particle size of from about 100 to about 1000 microns and a specific gravity of above about 1.05. Biocompatible polymers that can be used are polysaccharides, proteins and synthetic polymers and the weighing material can be metals, metal alloys, metal oxides or ceramics.Type: GrantFiled: April 5, 1989Date of Patent: March 31, 1992Assignee: Verax CorporationInventors: Robert C. Dean, Jr., Frederick Cahn, Philip G. Phillips
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Patent number: 5019270Abstract: Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.Type: GrantFiled: October 9, 1990Date of Patent: May 28, 1991Assignee: PerSeptive Biosystems, Inc.Inventors: Noubar B. Afeyan, Fred E. Regnier, Robert C. Dean, Jr.
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Patent number: 4997753Abstract: Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.Type: GrantFiled: August 14, 1989Date of Patent: March 5, 1991Assignee: Verax CorporationInventors: Robert C. Dean, Jr., Frederick H. Silver, Richard A. Berg, Philip G. Phillips, Peter W. Runstadler, Jr.
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Patent number: 4978616Abstract: A fluidized bed reactor and reaction process, particularly well-suited for culturing cells, for example, for tissue culture and fermentation processes, are described which involve the treatment of at least a portion of the fluid exiting the fluidized bed reactor in a side loop in a manner to alter its temperature or composition, e.g., oxygenation, with recirculation of this treated fluid to the reactor as a portion of the fluid causing bed fluidization.Type: GrantFiled: September 3, 1987Date of Patent: December 18, 1990Assignee: Verax CorporationInventors: Robert C. Dean, Jr., Peter V. Grela, Subhash B. Karkare, Peter W. Runstadler, Jr.
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Patent number: 4863856Abstract: Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.Type: GrantFiled: November 18, 1986Date of Patent: September 5, 1989Assignee: Verax CorporationInventors: Robert C. Dean, Jr., Frederick H. Silver, Richard A. Berg, Philip G. Phillips, Peter W. Runstadler, Jr., Gennaro J. Maffia
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Patent number: 4861714Abstract: Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.Type: GrantFiled: April 4, 1985Date of Patent: August 29, 1989Assignee: Verax CorporationInventors: Robert C. Dean, Jr., Frederick H. Silver, Richard A. Berg, Philip G. Phillips, Peter W. Runstadler, Jr.
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Patent number: 4141346Abstract: An improved ocular plethysmograph for use in conjunction with known pulse volume recorders, and offering increased performance and simplicity as well as lower cost of manufacture. The device employs a means whereby a large DC pressure signal is cancelled across a very sensitive DC pressure transducer employed to detect directly the tiny pressure fluctuations resulting from minute volume plethysmic changes of the human ocular globe. The means employed provides secondary advantages in use.Type: GrantFiled: February 7, 1977Date of Patent: February 27, 1979Assignee: Life Sciences, Inc.Inventors: Robert C. Dean, Jr., Paul A. Hoisington, Brian F. Walsh, Frank E. Mastro