Patents by Inventor Robert C. Hider
Robert C. Hider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080146987Abstract: Embodiments of the present invention are directed to methods, apparatuses, and systems for the treatment of various skin conditions by delivery of piperine and/or a related structural analog of piperine (collectively referred to as piperine-based compounds) to an area of skin affected by a skin condition (e.g., vitiligo) in conjunction with irradiation of the affected area. Structural analogs of piperine include compounds such as THP, CHP, and RCHP. In various embodiments, irradiation of affected skin in conjunction with a piperine-based composition may result in stimulation of melanin synthesis by melanocytes which may induce pigmentation to a greater extent than with the use of the piperine-based compound alone.Type: ApplicationFiled: November 27, 2007Publication date: June 19, 2008Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Amala Soumyanath, Antony R. Young, Laura Faas, Radhakrishnan Venkatasamy, Robert C. Hider, Susan Walker
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Patent number: 7122561Abstract: The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.Type: GrantFiled: July 31, 2003Date of Patent: October 17, 2006Assignee: BTG International LimitedInventors: Amala Raman, Zhixiu Lin, Robert C. Hider, Radhakrishnan Venkatasamy
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Publication number: 20040061142Abstract: The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.Type: ApplicationFiled: July 31, 2003Publication date: April 1, 2004Applicant: BTG International LimitedInventors: Amala Raman, Zhixiu Lin, Robert C. Hider, Radhakrishnan Venkatasamy
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Patent number: 6680391Abstract: The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.Type: GrantFiled: January 22, 2002Date of Patent: January 20, 2004Assignee: BTG International LimitedInventors: Amala Raman, Zhixiu Lin, Robert C. Hider, Radhakrishnan Venkatasamy
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Publication number: 20020168369Abstract: The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.Type: ApplicationFiled: January 22, 2002Publication date: November 14, 2002Applicant: BTG International LimitedInventors: Amala Raman, Zhixu Lin, Robert C. Hider, Radhakrishnan Venkatasamy
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Patent number: 5480894Abstract: 3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl or 2-pivoloyloxyethyl group and R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen and methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl and 2-pivaloyloxyethyl groups with the provisos that (a) one only of R.sub.1 to R.sub.4 is either a 2-(.alpha.-methylpropionyloxy)ethyl group or a 2-pivaloyloxyethyl group, (b) at least one of R.sub.2 and R.sub.3 is other than hydrogen and (c) the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than eleven, and physiologically acceptable salts thereof are of use in therapy, particularly in the treatment of conditions in which there is a toxic concentration of a metal, for example iron, in the body.Type: GrantFiled: March 7, 1994Date of Patent: January 2, 1996Assignee: British Technology Group LimitedInventors: Robert C. Hider, Surinder Singh, Gary S. Tilbrook, Paul S. Dobbin
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Patent number: 5256676Abstract: 3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a C.sub.3 or C.sub.4 hydroxyalkyl group in which the hydroxy group is terminally substituted on the alkyl group, R.sub.2 is methyl or ethyl and R.sub.3 and R.sub.4 are each separately hydrogen, methyl or ethyl but with the proviso that the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than six, the compound optionally being in the form of a physiologically acceptable salt and/or pro-drug thereof, are of value for the treatment of conditions caused by iron dependent parasites, particularly malaria.Type: GrantFiled: July 24, 1992Date of Patent: October 26, 1993Assignee: British Technology Group LimitedInventors: Robert C. Hider, Timothy E. A. Peto, Surinder Singh, Susan Whitehead
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Patent number: 5185319Abstract: Admixture of insulin and a hydroxypyridone being: (1) a 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen and hydroxy groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen or hydroxy group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, cycloalkoxy, aliphatic ester, halogen or hydroxy group, or a salt thereof.Type: GrantFiled: May 3, 1990Date of Patent: February 9, 1993Assignee: National Research Development CorporationInventors: Robert C. Hider, Michael A. Stockham
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Patent number: 5177068Abstract: Iron complexes comprising a ferric cation in combination with at least two different ligands, at least one of which is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, alphatic amide, aliphatic ester, halogen and hydroxy groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group; the chType: GrantFiled: May 8, 1989Date of Patent: January 5, 1993Assignee: National Research Development CorporationInventors: Brian A. Callingham, Robert C. Hider, George Kontoghiorghes, Michael A. Stockham
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Patent number: 5104865Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.Type: GrantFiled: September 1, 1989Date of Patent: April 14, 1992Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 5028411Abstract: Pharmaceutical compositions for the buccal or nasal administration of a neutral 3:1 hydroxypyrone:iron(III) complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of value for the treatment of iron deficiency anaemia.Type: GrantFiled: March 2, 1989Date of Patent: July 2, 1991Assignee: National Research Development CorporationInventors: Brian A. Callingham, Robert C. Hider, George Kontoghiorghes, Michael A. Stockham
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Patent number: 4912118Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroypyrid-4-one or 1-hydropyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficienType: GrantFiled: December 22, 1986Date of Patent: March 27, 1990Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4894455Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroType: GrantFiled: February 18, 1987Date of Patent: January 16, 1990Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4866052Abstract: Neutral 2:1 ligand:zinc(II) complexes in which at least one ligand is provided by a compound being 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of value for use in effecting an enhancement of the oxygen binding ability of a patient's haemoglobin, this being of particular application in the treatment of sickle cell disease.Type: GrantFiled: November 2, 1987Date of Patent: September 12, 1989Assignee: National Research Development CorporationInventors: Robert C. Hider, Ernst R. Huehns
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Patent number: 4861767Abstract: Pharmaceutical compositions containing an iron complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of value for the treatment of iron deficiency anaemia.Type: GrantFiled: July 13, 1987Date of Patent: August 29, 1989Assignee: National Research CorporationInventors: Robert C. Hider, George Kontoghiorghes, Michael A. Stockham
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Patent number: 4840958Abstract: Pharmaceutical compositions containing a 3-hydroxyprid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or a salt thereof containing a physiologically acceptable cation, are of value for removing toxic amounts of metals, particularly iron, from the body. These compositions are useful in the treatment of iron overloads.Type: GrantFiled: November 20, 1986Date of Patent: June 20, 1989Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
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Patent number: RE37534Abstract: Pharmaceutical compositions containing an iron complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, are of value for the treatment of iron deficiency anaemia.Type: GrantFiled: January 31, 1997Date of Patent: January 29, 2002Assignee: BTG International LimitedInventors: Robert C. Hider, George Kontoghiorghes, Michael A. Stockham
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Patent number: RE34313Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of valType: GrantFiled: October 1, 1991Date of Patent: July 13, 1993Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: RE35948Abstract: Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron, fType: GrantFiled: February 17, 1995Date of Patent: November 3, 1998Assignee: British Technology Group Ltd.Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
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Patent number: RE36831Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.Type: GrantFiled: February 17, 1995Date of Patent: August 22, 2000Assignee: British Technology Group Ltd.Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham