Abstract: A computer system for managing applied knowledge and workflows in multiple dimensions and contexts which includes: an assessor program for screening subjects and collecting, assessing and creating objects to represent the subjects using flexible domain and subdomain descriptors; a system manager for identifying sentinel data; and at least one activity manager for creating and managing activity plans and completions for various types of task performers. In a preferred embodiment, the assessor program is able to interactively collect data about a subject and classify the information into a number of domain descriptors. Each object domain descriptor, in turn may have several subdomain descriptors. The system manager uses applied knowledge databases to identify which domain and subdomain descriptors for an object are significant for the overall assessment and system purposes and identifies these as sentinel data.