Patents by Inventor Robert C. Siegel

Robert C. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of cross-links in the helical domain of collagen using pyridoxal 5-phosphate and copper or iron
    Patent number: 4544638
    Abstract: Aldehyde cross-link intermediates and cross-links are generated in the central helical portion of collagen by incubating collagen with pyridoxal-5-phosphate and either cupric copper ion or ferrous iron ion. The cross-links are chemically similar to natural cross-links found in the non-helical regions and are directly between amino-acid moieties naturally occuring in the central helical portion of collagen. Cross-linking and utilization of aldehyde intermediates occurs when the product is reincubated after pyridoxal is removed. Alternatively maintaining the product at body temperatures will promote cross-linking. The cross-linked collagen product has increased resistance to enzyme degradation.
    Type: Grant
    Filed: May 18, 1984
    Date of Patent: October 1, 1985
    Assignee: The Regents of the University of California
    Inventor: Robert C. Siegel