Abstract: An example automated driving system computer can include a board, one or more processors coupled to the board, a first layer of a first thermal interface material applied on the one or more processors, a heat spreader having a first side and a second side, the first side in contact with the first layer of the first thermal interface material, a second layer of a second thermal interface material applied on the second side of the heat spreader, and a cold plate in contact with the second layer of the second thermal interface material.

Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: An electrostatic discharge (ESD) robust design for an input device such as a stylus is disclosed. The input device can include one or more components, such as one or more Schottky diodes, that can be damaged by ESD events. To reduce the likelihood of damage to sensitive components, the parasitic capacitance between sensitive conductive paths and reference ground paths of the input device that could otherwise provide electrostatic discharge paths can be reduced (arranging current limiting resistance at specific locations among sensitive components, creating physical separation between sensitive conductive paths and reference ground paths), shielding can be added to shield the sensitive electronics from ESD pulses, and high dielectric breakdown material can be added to prevent ESD pulse entry or exit of not otherwise protected circuit parts.

Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

Abstract: Implementations are described herein for leveraging digital media files retrieved and/or created by users to predict/determine topics of potential relevance to the users. In various implementations, digital media file(s) created and/or retrieved by a user with a client device may be applied as input across trained machine learning model(s), which in some cases are local to the client device, to generate output that indicates object(s) detected in the digital media file(s). Data indicative of the indicated object(s) may be provided to a remote computing system without providing the digital media file(s) themselves. In some implementations, information associated with the indicated object(s) may be retrieved and proactively output to the user. In some implementations, a frequency at which objects occur across a corpus of digital media files may be considered when determining a likelihood that a detected object is potentially relevant to a user.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared with the otherwise identical fucosylated antibodies. The invention includes uses, and associated methods of using the antibodies.

Abstract: A brush, rotatably arranged in a cleaning device for cleaning surfaces, is described. The brush includes a core element and brush elements arranged on the core element. The brush elements are arranged in a bristle field extending in a direction of a longitudinal axis of the brush and in a peripheral direction about the longitudinal axis. Further, the brush elements include fiber hairs. Furthermore, a linear mass density of at least tip portions of the brush elements is lower than 15 g per 10 km. In addition, an average of a packing density of the brush elements in the bristle field is lower than 15,000 brush elements per 1 cm2 so as to ensure that for the purpose of moving the brush during a cleaning action, only a relatively small amount of energy is needed.

Abstract: An implantable medical device system is configured to generate signals representing activity of a heart of a patient; determine, based on the signals, an intrinsic delay of the heart of the patient; determine whether the intrinsic delay is indicative of a first-degree heart block being present in the heart of the patient; determine a patient-specific timing regime for conduction system pacing based on whether the intrinsic delay is indicative of the first-degree heart block being present in the heart of the patient; and administer cardiac pacing to a native conduction system of the heart of the patient based on the timing regime.

Abstract: An example sensor bracket assembly can include one or more cold plates forming a core bracket structure, wherein the core bracket structure and the one or more cold plates provide structural support for the sensor bracket assembly; a housing enclosing the core bracket structure; one or more sensor mounts for mounting one or more sensors on the sensor bracket assembly; and one or more attachment portions for attaching the sensor bracket assembly to a body of a vehicle.

Abstract: The subject disclosure relates to a water-tight sealed stud assembly for high current applications. The water-tight sealed stud assembly can include a stud, a sealing ring, a sleeve, and a body. The stud may have a stud base and a thickened portion having an annular groove. The sealing ring may be disposed in the annular groove. The sleeve may be disposed circumferentially around the stud and made of a conductive material. The body may be disposed circumferentially around the sleeve and made of a non-conductive material. Systems and methods are also provided.

Abstract: Various technologies described herein pertain to a sensor for an autonomous vehicle that includes one or more heat dissipation features. A sensor includes a top cover and a bottom cover, where the top cover and the bottom cover form at least a portion of a casing of the sensor. The sensor includes a coldplate, a first printed circuit board, and a second printed circuit board. A top side of the first printed circuit board is coupled to the top cover and a bottom side of the first printed circuit board is coupled to a top side of the coldplate. A top side of the second printed circuit board is coupled to a bottom side of the coldplate and a bottom side of the second printed circuit board is coupled to the bottom cover. Various features described herein enhance heat transfer from components on the first and second printed circuit boards.

Abstract: An example sensor bracket assembly can include one or more cold plates forming a core bracket structure, wherein the core bracket structure and the one or more cold plates provide structural support for the sensor bracket assembly; a housing enclosing the core bracket structure; one or more sensor mounts for mounting one or more sensors on the sensor bracket assembly; and one or more attachment portions for attaching the sensor bracket assembly to a body of a vehicle.

Abstract: Two-phase cooling systems for autonomous driving super computers (ADSC) are described herein. In some examples, a two-phase cooling system can include a flow channel configured to circulate a flow; an evaporative heat exchanger comprising an inlet for receiving fluid from the flow channel and an outlet for releasing vapor generated from the fluid, the evaporative heat exchanger being configured to collect heat from components of the ADSC and transfer the heat away via the vapor released from the first outlet; a condensing heat exchanger configured to condense the vapor and remove latent heat associated with the vapor, the condensing heat exchanger comprising an inlet to the flow channel for receiving the vapor and an outlet to the flow channel for discharging fluid generated by condensing the vapor; and a pump configured to receive the fluid from the condensing heat exchanger and circulate the fluid to the evaporative heat exchanger.

Abstract: The subject disclosure relates to a water-tight sealed stud assembly for high current applications. The water-tight sealed stud assembly can include a stud, a sealing ring, a sleeve, and a body. The stud may have a stud base and a thickened portion having an annular groove. The sealing ring may be disposed in the annular groove. The sleeve may be disposed circumferentially around the stud and made of a conductive material. The body may be disposed circumferentially around the sleeve and made of a non-conductive material. Systems and methods are also provided.

Abstract: An example automated driving system computer can include a board, one or more processors coupled to the board, a first layer of a first thermal interface material applied on the one or more processors, a heat spreader having a first side and a second side, the first side in contact with the first layer of the first thermal interface material, a second layer of a second thermal interface material applied on the second side of the heat spreader, and a cold plate in contact with the second layer of the second thermal interface material.

Abstract: Two-phase cooling systems for autonomous driving super computers (ADSC) are described herein. In some examples, a two-phase cooling system can include a flow channel configured to circulate a flow; an evaporative heat exchanger comprising an inlet for receiving fluid from the flow channel and an outlet for releasing vapor generated from the fluid, the evaporative heat exchanger being configured to collect heat from components of the ADSC and transfer the heat away via the vapor released from the first outlet; a condensing heat exchanger configured to condense the vapor and remove latent heat associated with the vapor, the condensing heat exchanger comprising an inlet to the flow channel for receiving the vapor and an outlet to the flow channel for discharging fluid generated by condensing the vapor; and a pump configured to receive the fluid from the condensing heat exchanger and circulate the fluid to the evaporative heat exchanger.

Abstract: A method of rendering a graphical object (e.g., 801) on a page (800), is disclosed. A region of the page containing the graphical object (801) is marked as output incompatible based on the graphical object (801) being output incompatible. A bounding box comprising the marked region is determined. A proportion of a number of the regions marked as output incompatible are determined to a total number of regions in the bounding box. A further region within the bounding box is marked as output incompatible to increase the determined proportion above a threshold. The graphical object in the marked region and the further marked region is converted into an output compatible graphical object if the determined proportion is above the threshold. The output compatible graphical object is rendered.

Abstract: A method of rendering a graphical object (e.g., 801) on a page (800), is disclosed. A region of the page containing the graphical object (801) is marked as output incompatible based on the graphical object (801) being output incompatible. A bounding box comprising the marked region is determined. A proportion of a number of the regions marked as output incompatible are determined to a total number of regions in the bounding box. A further region within the bounding box is marked as output incompatible to increase the determined proportion above a threshold. The graphical object in the marked region and the further marked region is converted into an output compatible graphical object if the determined proportion is above the threshold. The output compatible graphical object is rendered.

Abstract: A method for generating an outline for a stroked line of specified width from an input line (601) defined by a vector having two input points (P0, P1) is disclosed. The method comprises the steps of: determining an offset vector based on the vector, the offset vector having components [Xoff, Yoff]; determining a first set of two pairs of points (L1, L2 and R1, R2) based on the offset vector applied to the two input points (P0, P1); and determining a second set of two pairs of points (L0, L3 and R0, R3) based on the first set of points (L1, L2 and R1, R2). The second set of two pairs of points (L0, L3 and R0, R3) defines at least a portion of the outline and one of the components of the offset vector [Xoff, Yoff] is independent of the inclination of the vector and the specified width.

Abstract: A method of rendering a graphical object (e.g., 801) on a page (800), is disclosed. A region of the page containing the graphical object (801) is marked as output incompatible based on the graphical object (801) being output incompatible. A bounding box comprising the marked region is determined A proportion of a number of the regions marked as output incompatible are determined to a total number of regions in the bounding box. A further region within the bounding box is marked as output incompatible to increase the determined proportion above a threshold. The graphical object in the marked region and the further marked region is converted into an output compatible graphical object if the determined proportion is above the threshold. The output compatible graphical object is rendered.