Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

Abstract: The disclosed system may include a substructure configured to support various components, an actuator configured to provide substantially linear motion along a specified axis in response to an electrical input, an input component hingedly coupled to the substructure, where the input component is configured to receive input from a user, and a mechanical linkage coupled to the input component and to at least a portion of the actuator. The mechanical linkage may be configured to translate the substantially linear motion provided by the actuator to a rotary force applied to the input component via the mechanical linkage. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The invention is directed to a sandwich colored hydrogel contact lenses lens, comprising: a pupil section, a generally annular iris section surrounding the pupil section, wherein the iris section having at least one colored, printed, opaque, intermittent pattern, wherein the said pattern is covered by a clear donut shape-layer layer, wherein the clear donut shape-layer layer is on inner surface of lens to the observer and has a thickness at least 25 ?m. And the method make such lenses using a common polypropylene base curve (BC Mold 1) and two different front curve molds (FC Mold 1, FC Mold 2) that provided different volume gaps to accommodate the size requirements of the two layers.

Abstract: Certain aspects relate to systems and techniques for robotic medical instrument system. The medical instrument system can include a pulley and a capstan. The capstan can be supported for rotation about a rotational axis and translation along the rotational axis. A cable can be wrapped around the capstan and extending from the capstan to the pulley. The capstan can be configured to translate relative to the pulley along the rotational axis as the capstan rotates about the rotational axis.

Abstract: Described herein is a colored hydrogel contact lens, comprising: a hydrogel material; at least one cosmetic colored film; wherein the cosmetic colored film is made of a thermal plastic material or thermal setting material and is surrounded by the hydrogel material, wherein the colored hydrogel contact lens is capable of absorbing from about 10% to about 75% by weight of water when being fully hydrated, wherein the contact lens has an anterior surface and an opposite posterior surface and a circumferential edge where the anterior and posterior surfaces are tapered off, wherein the contact lens comprises a central optical zone, a peripheral zone surrounding the central optical zone, and an edge zone surrounding the peripheral zone.

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

Abstract: Lipid bilayer particles, such as extracellular vesicles (EVs), are labeled with lipid-tagged single-stranded DNA (ssDNA), which is amplified by polymerase chain reaction (PCR) to quantify particles captured via surface marker interactions or complementary oligonucleotide hybridization.

Abstract: The invention is directed to a cosmetic functional contact lens having a pupil section, a generally annular iris section surrounding the pupil section for detecting at least one target analyte or physical attribute, comprising: a substrate for supporting electronic components and providing structural support for the functional contact lens; at least one sensing element disposed on the substrate for sensing the at least one target analyte or physical attribute and undergoing a physical change representing a sensed signal; an antenna disposed on the substrate for transmitting the sensed signal to an external device, the antenna being coupled to the at least one sensing element; a colored, printed, opaque, intermittent cosmetic pattern to mask the embedded electronic components.

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

Abstract: The disclosed system may include a substructure configured to support various components, an actuator configured to provide substantially linear motion along a specified axis in response to an electrical input, an input component hingedly coupled to the substructure, where the input component is configured to receive input from a user, and a mechanical linkage coupled to the input component and to at least a portion of the actuator. The mechanical linkage may be configured to translate the substantially linear motion provided by the actuator to a rotary force applied to the input component via the mechanical linkage. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.

Abstract: The invention is related to a contact lens, especially a SiHy contact lens, which comprises a lens bulk material covered with an outer surface hydrogel layer thereon and has a posterior surface and an opposite anterior surface. The outer surface hydrogel layer consists of an anterior outer hydrogel layer and a posterior outer hydrogel layer. A contact lens of the invention is characterized by having a difference in surface softness between its posterior (BC) and anterior (FC) surfaces.

Abstract: A method of manufacturing a colored contact lens including the steps of providing a transparent contact lens having a pupil section and an iris section, the iris section surrounding the pupil section and applying a colorant to the surface of the contact lens. The colorant is applied to the contact lens as an amorphous pattern and covers an effective amount of the iris section of the same. The amorphous pattern provides a lens capable of changing the apparent color of the iris of a person wearing the lens while imparting a very natural appearance.

Abstract: Certain aspects relate to systems and techniques for robotic medical instrument system. The medical instrument system can include a pulley and a capstan. The capstan can be supported for rotation about a rotational axis and translation along the rotational axis. A cable can be wrapped around the capstan and extending from the capstan to the pulley. The capstan can configured to translate relative to the pulley along the rotational axis as the capstan rotates about the rotational axis.

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

Abstract: A hand-held controller is enables a user to manipulate objects in a VR environment with hand movement. The hand-held controller includes a handle, a ring attached to an end of the handle and one or more light emitting diodes (LEDs). The handle has appropriate shape and dimensions so that it can be grasped by the user's hand. The ring has an outer body that includes an inner surface that is formed with one or more concave dome and an outer surface facing away from the inner surface. Each of the one or more LED is mounted under a concaved dome. Light emitted from the LED spreads at the concaved dome to form uniform illuminous intensity. The light transmits out of the body through the outer surface of the outer body. The light can be captured by a camera for tracking the hand-held controller.

Abstract: The invention is generally related to colored contact lenses which comprise a hydrogel lens body having an opaque color image therein and/or thereon and a durable lubricious coating thereon. The coating comprises an anchoring layer of a polyanionic polymer having carboxyl groups and a hydrogel layer which is derived from a hydrophilic polymeric material having azetidinium groups and is covalently attached onto the anchoring layer of the polyanionic polymer through linkages each formed between one carboxyl group and one azetidinium groups. The colored contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and a friction rating of about 2 or lower after 7 cycles of manual rubbing.